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Csnk1a1
Gene Detail
Symbol

Name
ID
Csnk1a1
casein kinase 1, alpha 1
MGI:1934950
Synonyms
2610208K14Rik, 4632404G05Rik, 5430427P18Rik, CK1a
Feature Type
protein coding gene
Genetic Map
Chromosome 18
34.62 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:61555274-61590061 bp, + strand
From VEGA annotation of GRCm38

  34788 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:111694  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CSNK1A1
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Csnk1a1

Human
homologs
CSNK1A1, casein kinase 1, alpha 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1452
neXtProt AC: NX_P48729

Human Synonyms: CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975

Human Chr (Location): 5q32; chr5:149495894-149551552 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(38) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit complete embryonic lethality.
 
Interactions
Csnk1a1 interacts with 425 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell cycle, cell division, ...
Component centrosome, chromosome, ...
Function ATP binding, glycoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (86)    Tissues (73)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 86
cDNA source data(341)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase csnk1a1 ; ZFIN csnk1a1    NEW 
Molecular
reagents
All nucleic(343) cDNA(342) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000035876 (Evidence)
Ensembl Gene Model ENSMUSG00000024576 (Evidence)
Entrez Gene 93687 (Evidence)
UniGene 26908
DFCI TC1584994, TC1605869, TC1572012, TC1643294, TC1632500, TC1711046, TC1754013
DoTS DT.101171666, DT.110756546, DT.101388474, DT.101283768, DT.101388473, DT.495165, DT.99865035, DT.94377142, DT.94421618
EC 2.7.11.1
Consensus CDS Project CCDS37838.1
International Mouse Phenotyping Consortium Status Csnk1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035876 VEGA Gene Model | MGI Sequence Detail 34788 C57BL/6J ±  kb
transcript OTTMUST00000091975 VEGA | MGI Sequence Detail 1860 Not Applicable 
polypeptide OTTMUSP00000050733 VEGA | MGI Sequence Detail 374 Not Applicable 

For the selected sequences
All sequences(137) RefSeq(18) UniProt(11)
Polymorphisms
SNPs within 2kb(206 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005943 casein kinase I isoform alpha
References
(Earliest) J:46689 McInnes C, et al., Tissue-specific distribution of mouse casein kinase I alpha mRNA. DNA Seq. 1997;8(1-2):55-7
(Latest) J:202528 Pribluda A, et al., A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell. 2013 Aug 12;24(2):242-56
All references(48)
Other
accession IDs
MGI:1914042, MGI:1915311, MGI:1926085

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory