About   Help   FAQ
Csnk1a1 Gene Detail
Summary
  • Symbol
    Csnk1a1
  • Name
    casein kinase 1, alpha 1
  • Synonyms
    2610208K14Rik, 4632404G05Rik, 5430427P18Rik, CK1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934950
    NCBI Gene: 93687
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:61555274-61590061 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34788 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 34.62 cM, cytoband D3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CSNK1A1, casein kinase 1 alpha 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CSNK1A1, casein kinase 1 alpha 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975
  • Links
    NCBI Gene ID: 1452
    neXtProt AC: NX_P48729
    UniProt: P48729

  • Chr Location
    5q32; chr5:149495894-149551552 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035876 VEGA Gene Model | MGI Sequence Detail 34788 C57BL/6J ±  kb
    transcript OTTMUST00000091975 VEGA | MGI Sequence Detail 1860 Not Applicable  
    polypeptide OTTMUSP00000050733 VEGA | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      205 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 343
      cDNA 342
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1914042, MGI:1915311, MGI:1926085
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:46689 McInnes C, et al., Tissue-specific distribution of mouse casein kinase I alpha mRNA. DNA Seq. 1997;8(1-2):55-7
    • Latest
      J:260334 Li B, et al., Differential abundance of CK1alpha provides selectivity for pharmacological CK1alpha activators to target WNT-dependent tumors. Sci Signal. 2017 Jun 27;10(485)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory