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Csnk1a1
Gene Detail
Symbol

Name
ID
Csnk1a1
casein kinase 1, alpha 1
MGI:1934950
Synonyms
2610208K14Rik, 4632404G05Rik, 5430427P18Rik, CK1a
Feature Type
protein coding gene
Genetic Map
Chromosome 18
34.62 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:61555274-61590061 bp, + strand
From VEGA annotation of GRCm38

  34788 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:111694  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Csnk1a1

Human
homologs
Human Homolog CSNK1A1, casein kinase 1, alpha 1
NCBI Gene ID 1452
neXtProt AC  NX_P48729
Human Synonyms  CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975
Human Chr (Location)  5q32; chr5:149495894-149551552 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(38) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit complete embryonic lethality.
 
Interactions
Csnk1a1 interacts with 425 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cell cycle, cell division, ...
Component centrosome, chromosome, ...
Function ATP binding, glycoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (86)    Tissues (73)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 86
cDNA source data(341)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(343) cDNA(342) Primer pair(1)
Microarray probesets(8)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035876 VEGA Gene Model | MGI Sequence Detail 34788 C57BL/6J ±  kb
transcript OTTMUST00000091975 VEGA | MGI Sequence Detail 1860 Not Applicable 
polypeptide OTTMUSP00000050733 VEGA | MGI Sequence Detail 374 Not Applicable 

For the selected sequences
All sequences(134) RefSeq(16) UniProt(11)
Polymorphisms
SNPs within 2kb(206 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005943 casein kinase I isoform alpha
References
(Earliest) J:46689 McInnes C, et al., Tissue-specific distribution of mouse casein kinase I alpha mRNA. DNA Seq. 1997;8(1-2):55-7
(Latest) J:202528 Pribluda A, et al., A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell. 2013 Aug 12;24(2):242-56
All references(49)
Other
accession IDs
MGI:1914042, MGI:1915311, MGI:1926085

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory