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Setdb1 Gene Detail
Summary
  • Symbol
    Setdb1
  • Name
    SET domain, bifurcated 1
  • Synonyms
    ESET, KMT1E, mKIAA0067
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934229
    NCBI Gene: 84505
  • Gene Overview
    MyGene.info: SETDB1
Location & Maps
more
  • Sequence Map
    Chr3:95323525-95357202 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33678 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM, cytoband F2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SETDB1, SET domain bifurcated 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SETDB1, SET domain bifurcated 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21
  • Links
    NCBI Gene ID: 9869
    neXtProt AC: NX_Q15047

  • Chr Location
    1q21; chr1:150926339-150964901 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 6 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    43
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Gene trapped
    33
  • Radiation induced
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Setdb1
  • Incidental Mutations
Homozygous inactivation of this locus results in peri-implantation lethality. Inner cell mass growth is impaired in null blastocysts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046460 VEGA Gene Model | MGI Sequence Detail 33678 C57BL/6J ±  kb
transcript OTTMUST00000041441 VEGA | MGI Sequence Detail 4622 Not Applicable  
polypeptide OTTMUSP00000018599 VEGA | MGI Sequence Detail 1308 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    151 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 4
Other
Accession IDs
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MGI:2139889
References
more
  • Summaries
    All 66
    Developmental Gene Expression 14
    Gene Ontology 9
    Phenotypes 22
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:223742 Collins PL, et al., The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8367-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory