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Setdb1 Gene Detail
Summary
  • Symbol
    Setdb1
  • Name
    SET domain, bifurcated 1
  • Synonyms
    ESET, KMT1E, mKIAA0067
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934229
    NCBI Gene: 84505
  • Gene Overview
    MyGene.info: SETDB1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95323525-95357202 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934229
protein coding gene Chr3:95323525-95357202 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027583
protein coding gene Chr3:96047778-96084023 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0027554
protein coding gene Chr3:92843353-92931735 (-)
C3H/HeJ MGP_C3HHeJ_G0027287
protein coding gene Chr3:95498933-95533012 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0025342
protein coding gene Chr3:89429994-89463912 (-)
CAST/EiJ MGP_CASTEiJ_G0026737
protein coding gene Chr3:94794602-94827087 (-)
CBA/J MGP_CBAJ_G0027264
protein coding gene Chr3:103228623-103263347 (-)
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0027512
protein coding gene Chr3:97354369-97394383 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027401
protein coding gene Chr3:109326317-109373033 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0026465
protein coding gene Chr3:92241057-92277591 (-)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SETDB1, SET domain bifurcated 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SETDB1, SET domain bifurcated 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21
  • Links
    NCBI Gene ID: 9869
    neXtProt AC: NX_Q15047
    UniProt: Q15047

  • Chr Location
    1q21.3; chr1:150926246-150964744 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32157
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SETDB1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 5 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus results in peri-implantation lethality. Inner cell mass growth is impaired in null blastocysts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 84505 NCBI Gene Model | MGI Sequence Detail 33678 C57BL/6J ±  kb
    transcript NM_001163641 RefSeq | MGI Sequence Detail 4682 C57BL/6  
    polypeptide O88974 UniProt | EBI | MGI Sequence Detail 1307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139889
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 9
      Phenotypes 32
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:257670 Yang L, et al., Generation and characterization of mice with mesenchyme-specific deletion of the entire ESET histone methyltransferase protein. Genesis. 2018 Feb;56(2)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory