Sequence Detail

ID/Version

O88974 Q78N64 Q78N65 Q8BTV6 Q8CIX7 Q6AXH8 Q80U84 Q922K1 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Histone-lysine N-methyltransferase SETDB1 {ECO:0000305}; EC=2.1.1.366 {ECO:0000269|PubMed:11791185, ECO:0000269|PubMed:22939622};AltName: Full=ERG-associated protein with SET domain; Short=ESET {ECO:0000303|PubMed:20164836};A

Provider

SWISS-PROT

Sequence

Polypeptide 1307 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Setdb1	SET domain, bifurcated 1	36	106	3	50

Sequence references in MGI

J:82069 Yang L, et al., An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. Biochem J. 2003 Feb 1;369(Pt 3):651-7
J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114022 Yang L, et al., Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. Oncogene. 2002 Jan 3;21(1):148-52
J:188475 Matsui T, et al., Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET. Nature. 2010 Apr 8;464(7290):927-31
J:268030 Fukuda K, et al., A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells. Genome Res. 2018 Jun;28(6):846-858
J:269562 Pinheiro I, et al., Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell. 2012 Aug 31;150(5):948-60
J:282162 Gresakova V, et al., [Retracted] Fam208a orchestrates interaction protein network essential for early embryonic development and cell division. Exp Cell Res. 2019 Sep 1;382(1):111437
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89