Setdb1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Setdb1
SET domain, bifurcated 1
MGI:1934229

33 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
\Setdb1^tm1.1Yshk/\Setdb1^tm1.1Yshk \Emx2^tm2(cre)Sia/\Emx2⁺ involves: C57BL/6NCrlj * CBA/JNCrlj	abnormal astrocyte morphology	J:188109
	abnormal cerebral cortex morphology	J:188109
	abnormal cortical plate morphology	J:188109
	abnormal nervous system development	J:188109
	abnormal neuron differentiation	J:188109
	abnormal neuronal precursor proliferation	J:188109
	abnormal telencephalon development	J:188109
	decreased neuron number	J:188109
	decreased neuronal precursor cell number	J:188109
	increased neuron apoptosis	J:188109
	increased neuron number	J:188109
	loss of cortex neurons	J:188109
	postnatal lethality, complete penetrance	J:188109
\Setdb1^tm1.1Yshk/\Setdb1^tm1.1Yshk \H2az2^{Tg(Wnt1-cre)11Rth}/\H2az2⁺ involves: C57BL/6J * CBA/J	abnormal palatal mesenchymal cell proliferation	J:321816
	abnormal secondary palate development	J:321816
	abnormal tooth development	J:321816
	cleft secondary palate	J:321816
	delayed palatal shelf elevation	J:321816
	neonatal lethality, complete penetrance	J:321816
	tongue hypoplasia	J:321816
\Setdb1^tm1.1Yshk/\Setdb1^tm1.1Yshk \Tg(Nes-cre)1Kag/0 Not Specified	abnormal astrocyte morphology	J:188109
	postnatal lethality, complete penetrance	J:188109
\Setdb1^{tm1a(EUCOMM)Wtsi}/\Setdb1^{tm1a(EUCOMM)Wtsi} B6Brd;B6Dnk;B6N-Tyr^c-Brd Setdb1^{tm1a(EUCOMM)Wtsi}/Wtsi	preweaning lethality, complete penetrance	J:211773
\Setdb1^tm1Enl/\Setdb1^tm1Enl involves: 129S4/SvJae	decreased inner cell mass proliferation	J:89058
\Setdb1^tm1Enl/\Setdb1^tm1Enl involves: 129S4/SvJae	embryonic lethality between implantation and somite formation, complete penetrance	J:89058
\Setdb1^tm2.1Enl/\Setdb1^tm2.1Enl involves: 129/Sv * C57BL/6	no abnormal phenotype detected	J:161089
\Setdb1^tm2.1Enl/\Setdb1^tm2.2Enl involves: 129/Sv * C57BL/6	abnormal cell morphology	J:161089
	decreased cell proliferation	J:161089
\Setdb1^tm2.2Enl/\Setdb1^tm2.2Enl involves: 129/Sv * C57BL/6	embryonic lethality between implantation and placentation, complete penetrance	J:161089
\Tg(Camk2a-Setdb1)1Akba/0 involves: C57BL/6 * SJL	abnormal depression-related behavior	J:160826
	abnormal excitatory postsynaptic potential	J:160826
	abnormal NMDA-mediated synaptic currents	J:160826
	normal behavior/neurological phenotype	J:160826, J:178512
	impaired coordination	J:160826
	normal mortality/aging	J:178512

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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