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Targeted Allele Detail
Symbol: Setdb1tm1a(EUCOMM)Wtsi
Name: SET domain, bifurcated 1; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4432424
Gene: Setdb1  Location: Chr3:95230836-95264513 bp, - strand  Genetic Position: Chr3, 40.74 cM, cytoband F2
Alliance: Setdb1tm1a(EUCOMM)Wtsi page
IMPC: Setdb1 gene page
Mutant Cell Lines:  EPD0028_1_A08, EPD0028_1_A09, EPD0028_1_B07, EPD0028_1_B08, EPD0028_1_B09, EPD0028_1_C07, EPD0028_1_C08, EPD0028_1_D07, EPD0028_1_D08, EPD0028_1_D09, EPD0028_1_E07, EPD0028_1_E08, EPD0028_1_E09, EPD0028_1_F07, EPD0028_1_G08, EPD0028_1_H07, EPD0028_1_H08, EPD0028_1_H09
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt1
Mutation detailsThe L1L2_gt1 cassette was inserted at position 95350414 of Chromosome 3 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 95349598. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Setdb1 Mutation:  39 strains or lines available
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory