About   Help   FAQ
Hamp Gene Detail
Summary
  • Symbol
    Hamp
  • Name
    hepcidin antimicrobial peptide
  • Synonyms
    Hepc, HEPC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933533
    NCBI Gene: 84506
  • Gene Overview
    MyGene.info: HAMP
Location & Maps
more
  • Sequence Map
    Chr7:30942368-30944032 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1665 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 19.27 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    HAMP, hepcidin antimicrobial peptide
  • Vertebrate Orthologs
    2
  • Human Ortholog
    HAMP, hepcidin antimicrobial peptide
    Orthology source: HGNC
  • Synonyms
    HEPC, HFE2B, LEAP1, PLTR
  • Links
    NCBI Gene ID: 57817
    neXtProt AC: NX_P81172

  • Chr Location
    19q13.1; chr19:35282507-35285143 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Hamp mouse models; 1 with human HAMP associations

Human Disease Mouse Models
       Hemochromatosis, Type 2B; HFE2B   OMIM: 613313 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Targeted
    9
  • Transgenic
    3
Null mutations in this gene result in abnormal iron homeostasis, with massive iron accumulation observed in the liver, pancreas, and heart of mice. Serum iron content is also elevated, while splenic iron content is significantly decreased compared to wild type.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058034 VEGA Gene Model | MGI Sequence Detail 1665 C57BL/6J ±  kb
transcript OTTMUST00000142475 VEGA | MGI Sequence Detail 410 Not Applicable  
polypeptide OTTMUSP00000074318 VEGA | MGI Sequence Detail 83 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    77 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR010500 Hepcidin
Molecular
Reagents
less
  • All nucleic 21
    cDNA 18
    Primer pair 2
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 70
    Developmental Gene Expression 11
    Diseases 4
    Gene Ontology 23
    Phenotypes 30
  • Earliest
    J:8030 Venta PJ, et al., Structure and exon to protein domain relationships of the mouse carbonic anhydrase II gene. J Biol Chem. 1985 Oct 5;260(22):12130-5
  • Latest
    J:222266 Rausa M, et al., Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?. PLoS One. 2015;10(4):e0122696

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory