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Hamp
Gene Detail
Symbol

Name
ID
Hamp
hepcidin antimicrobial peptide
MGI:1933533
Synonyms
Hepc, HEPC1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
19.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:30942371-30944017 bp, - strand
From Ensembl annotation of GRCm38

  1647 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10911  Vertebrate Homology Class
2 mouse

Gene Tree: Hamp

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Null mutations in this gene result in abnromal iron homeostasis, with massive iron accumulation observed in the liver, pancreas, and heart of mice. Serum iron content is also elevated, while splenic iron content is significantly decreased compared to wild type.
 
Human Diseases Modeled Using Mouse Hamp (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Hamp interacts with 14 markers (Mir19b-1, Mir19b-2, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cellular iron ion homeostasis, defense response to bacterium, ...
Component cell, extracellular region, ...
Function copper ion binding, hormone activity
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (23)    Tissues (6)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 18
RT-PCR 5
cDNA source data(18)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000050440 (Evidence)
Entrez Gene84506 (Evidence)
UniGene439939
DFCITC1586235
DoTSDT.60118490
NIA Mouse Gene IndexU028406
Consensus CDS ProjectCCDS39895.1
International Mouse Knockout Project StatusHamp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050440 Ensembl Gene Model | MGI Sequence Detail 1647 C57BL/6J ±  kb
transcript ENSMUST00000062620 Ensembl | MGI Sequence Detail 392 Not Applicable 
polypeptide ENSMUSP00000055404 Ensembl | MGI Sequence Detail 83 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(78 from dbSNP Build 137)    SNPs within 2kb including multiple locations(138)
Protein-related
information
ResourceIDDescription
InterPro IPR010500 Hepcidin
Protein Ontology PR:000008438 hepcidin
References
(Earliest) J:8030 Venta PJ, et al., Structure and exon to protein domain relationships of the mouse carbonic anhydrase II gene. J Biol Chem. 1985 Oct 5;260(22):12130-5
(Latest) J:212430 Sun L, et al., Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload. Gene. 2014 Jun 10;543(1):161-5
All references(67)
Disease annotation references (3)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory