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Tlr9
Gene Detail
 Symbol
Name
ID
Tlr9
toll-like receptor 9
MGI:1932389
Feature Type protein coding gene
Genetic Map
Chromosome 9
57.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:106222598-106226876 bp, + strand
From NCBI annotation of GRCm38

  4279 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: toll-like receptor, 7/8/9 types
Gene Tree: Tlr9

Human
homologs
Human Homolog TLR9, toll-like receptor 9
NCBI Gene ID 54106
neXtProt AC  NX_Q9NR96
Human Synonyms  CD289
Human Chr (Location)  3p21.3; chr3:52221080-52226163 (-)  GRCh38
Alleles
and
phenotypes
All alleles(10) : Chemically induced (ENU)(8) Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice exhibit impaired immune responses to CpG DNA and altered susceptibility to EAE and parasitic infection. ENU-induced mutants may exhibit altered susceptibility to viral infection or induced colitis and impaired immune response to unmethylated CpG oligonucleotides.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process defense response to Gram-negative bacterium, defense response to virus, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function interleukin-1 receptor binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (5)   
Theiler Stages: 22, 24, 26, 28
Assay TypeResults
Western blot 1
RT-PCR 5
cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000045322 (Evidence)
Entrez Gene81897 (Evidence)
UniGene44889
DFCITC1586724
DoTSDT.60103030
NIA Mouse Gene IndexU010969
Consensus CDS ProjectCCDS40755.1
International Mouse Knockout Project StatusTlr9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 81897 NCBI Gene Model | MGI Sequence Detail 4279 C57BL/6J ±  kb
transcript NM_031178 RefSeq | MGI Sequence Detail 3471 Not Specified 
polypeptide Q9EQU3 UniProt | EBI | MGI Sequence Detail 1032 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR027181 Toll-like receptor 9
Protein Ontology PR:000001160 Toll-like receptor 9
Graphical View of Protein Domain Structure
References (Earliest) J:66049 Hemmi H, et al., A Toll-like receptor recognizes bacterial DNA. Nature. 2000 Dec 7;408(6813):740-5
(Latest) J:210476 Wang JQ, et al., Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance. J Exp Med. 2014 Mar 10;211(3):413-26
All references(423)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory