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Tlr9
Gene Detail
 Symbol
Name
ID
Tlr9
toll-like receptor 9
MGI:1932389
Feature Type protein coding gene
Genetic Map
Chromosome 9
57.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:106222598-106226883 bp, + strand
From VEGA annotation of GRCm38

  4286 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: toll-like receptor, 7/8/9 types
Gene Tree: Tlr9

Human
homologs
Human Homolog TLR9, toll-like receptor 9
NCBI Gene ID 54106
neXtProt AC  NX_Q9NR96
Human Synonyms  CD289
Human Chr (Location)  3p21.3; chr3:52221080-52226163 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(8) Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice exhibit impaired immune responses to CpG DNA and altered susceptibility to EAE and parasitic infection. ENU-induced mutants may exhibit altered susceptibility to viral infection or induced colitis and impaired immune response to unmethylated CpG oligonucleotides.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Tlr9 interacts with 45 markers (Mir24-1, Mir24-2, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process defense response to Gram-negative bacterium, defense response to virus, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function interleukin-1 receptor binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (5)   
Theiler Stages: 22, 24, 26, 27, 28
Assay TypeResults
Western blot 1
RT-PCR 5
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000049422 (Evidence)
Ensembl Gene ModelENSMUSG00000045322 (Evidence)
Entrez Gene81897 (Evidence)
UniGene44889
DFCITC1586724
DoTSDT.60103030
NIA Mouse Gene IndexU010969
PDB4QDH
Consensus CDS ProjectCCDS40755.1
International Mouse Knockout Project StatusTlr9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049422 VEGA Gene Model | MGI Sequence Detail 4286 C57BL/6J ±  kb
transcript OTTMUST00000125992 VEGA | MGI Sequence Detail 3478 Not Applicable 
polypeptide OTTMUSP00000068182 VEGA | MGI Sequence Detail 1032 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR027181 Toll-like receptor 9
Protein Ontology PR:000001160 Toll-like receptor 9
References (Earliest) J:66049 Hemmi H, et al., A Toll-like receptor recognizes bacterial DNA. Nature. 2000 Dec 7;408(6813):740-5
(Latest) J:211986 Belmont L, et al., Expression of TLR9 in tumor-infiltrating mononuclear cells enhances angiogenesis and is associated with a worse survival in lung cancer. Int J Cancer. 2014 Feb 15;134(4):765-77
All references(428)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory