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Tlr9
Gene Detail
Symbol

Name
ID
Tlr9
toll-like receptor 9
MGI:1932389
Feature Type
protein coding gene
Genetic Map
Chromosome 9
57.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:106222598-106226883 bp, + strand
From VEGA annotation of GRCm38

  4286 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TLR9
Protein SuperFamily: toll-like receptor, 7/8/9 types
Gene Tree: Tlr9

Human
homologs
TLR9, toll-like receptor 9
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 54106
neXtProt AC: NX_Q9NR96

Human Synonyms: CD289

Human Chr (Location): 3p21.3; chr3:52221080-52226163 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(9) Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Nullizygous mice exhibit impaired immune responses to CpG DNA and altered susceptibility to EAE and parasitic infection. ENU-induced mutants may exhibit altered susceptibility to viral infection or induced colitis and impaired immune response to unmethylated CpG oligonucleotides.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Tlr9 interacts with 45 markers (Mir24-1, Mir24-2, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (6)    Tissues (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 1
RT-PCR 5
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000049422 (Evidence)
Ensembl Gene Model ENSMUSG00000045322 (Evidence)
Entrez Gene 81897 (Evidence)
UniGene 44889
DFCI TC1586724
DoTS DT.60103030
NIA Mouse Gene Index U010969
PDB 3WPF, 3WPG, 3WPH, 3WPI, 4QDH
Consensus CDS Project CCDS40755.1
International Mouse Phenotyping Consortium Status Tlr9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049422 VEGA Gene Model | MGI Sequence Detail 4286 C57BL/6J ±  kb
transcript OTTMUST00000125992 VEGA | MGI Sequence Detail 3478 Not Applicable 
polypeptide OTTMUSP00000068182 VEGA | MGI Sequence Detail 1032 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR027181 Toll-like receptor 9
Protein Ontology PR:000001160 Toll-like receptor 9
References
(Earliest) J:66049 Hemmi H, et al., A Toll-like receptor recognizes bacterial DNA. Nature. 2000 Dec 7;408(6813):740-5
(Latest) J:221896 Matsuda T, et al., TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus. Nat Commun. 2015;6:6514
All references(448)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory