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Wwox Gene Detail
Summary
  • Symbol
    Wwox
  • Name
    WW domain-containing oxidoreductase
  • Synonyms
    5330426P09Rik, 9030416C10Rik, WOX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931237
    NCBI Gene: 80707
  • Gene Overview
    MyGene.info: WWOX
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:114439655-115352708 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 60.99 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6976 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931237
protein coding gene Chr8:114439635-115352712 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034161
protein coding gene Chr8:117417106-118373081 (+)
A/J MGP_AJ_G0034141
protein coding gene Chr8:112637549-113568723 (+)
AKR/J MGP_AKRJ_G0034068
protein coding gene Chr8:115916949-116866906 (+)
BALB/cJ MGP_BALBcJ_G0034135
protein coding gene Chr8:112822510-113749638 (+)
C3H/HeJ MGP_C3HHeJ_G0033846
protein coding gene Chr8:116613017-117591401 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034655
protein coding gene Chr8:121435174-122396436 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031597
protein coding gene Chr8:105624521-106540350 (+)
CAST/EiJ MGP_CASTEiJ_G0033173
protein coding gene Chr8:116339846-117341255 (+)
CBA/J MGP_CBAJ_G0033819
protein coding gene Chr8:125721641-126758293 (+)
DBA/2J MGP_DBA2J_G0033975
protein coding gene Chr8:111871611-112794745 (+)
FVB/NJ MGP_FVBNJ_G0033918
protein coding gene Chr8:110858076-111775408 (+)
LP/J MGP_LPJ_G0034064
protein coding gene Chr8:117556740-118508220 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033965
protein coding gene Chr8:128473588-129456761 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034673
protein coding gene Chr8:115970290-116934996 (+)
PWK/PhJ MGP_PWKPhJ_G0032875
protein coding gene Chr8:111557482-112482630 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032715
protein coding gene Chr8:114628651-115598734 (+)
WSB/EiJ MGP_WSBEiJ_G0033289
protein coding gene Chr8:116659732-117636140 (+)



Homology
more
  • Human Ortholog
    WWOX, WW domain containing oxidoreductase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WWOX, WW domain containing oxidoreductase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D16S432E, EIEE28, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1
  • Links
    NCBI Gene ID: 51741
    neXtProt AC: NX_Q9NZC7
    UniProt: Q9NZC7

  • Chr Location
    16q23.1-q23.2; chr16:78099413-79212667 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human WWOX associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    79 phenotypes from 5 alleles in 6 genetic backgrounds
    8 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in premature death and increased incidence of tumor development. Reduced male fertility and testicular atrophy are also observed in mice with a hypomorphic allele.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004637 Ensembl Gene Model | MGI Sequence Detail 913054 C57BL/6J ±  kb
    transcript ENSMUST00000004756 Ensembl | MGI Sequence Detail 2244 Not Applicable  
    polypeptide ENSMUSP00000004756 Ensembl | MGI Sequence Detail 414 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1918787, MGI:1925520
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:236247 Del Mare S, et al., WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma. Cancer Res. 2016 Oct 15;76(20):6107-6117

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory