Wwox
Gene Detail

Symbol Name ID

Wwox WW domain-containing oxidoreductase MGI:1931237

Synonyms

5330426P09Rik, 9030416C10Rik, WOX1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

60.99 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:114439655-115352708 bp, + strand From VEGA annotation of GRCm38   913054 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56334  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: WW domain-containing oxidoreductase
Gene Tree: Wwox

Human homologs

Human Homolog		WWOX, WW domain containing oxidoreductase
NCBI Gene ID		51741
neXtProt AC		NX_Q9NZC7
Human Synonyms		D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, WOX1
Human Chr (Location)		16q23.3-q24.1; chr16:78133327-79246564 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human WWOX

Alleles and phenotypes

All alleles(33) : Targeted(5) Gene trapped(28)
 

Homozygous mutation of this gene results in premature death and increased incidence of tumor development. Reduced male fertility and testicular atrophy are also observed in mice with a hypomorphic allele.

 
Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	apoptotic process, cellular response to transforming growth factor beta stimulus, ...
Component	cytoplasm, cytosol, ...
Function	enzyme binding, oxidoreductase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (140)    Tissues (102)   
Theiler Stages: 13, 15, 17, 19, 20, 22, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	128
Western blot	12

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(8)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000030624 (Evidence)
Ensembl Gene Model	ENSMUSG00000004637 (Evidence)
Entrez Gene	80707 (Evidence)
DFCI	TC1576521, TC1592791, TC1613257
DoTS	DT.101722619, DT.60104019, DT.87038150, DT.94161601, DT.94161602
EC	1.1.1.-
Consensus CDS Project	CCDS22691.1
International Mouse Knockout Project Status	Wwox

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030624	VEGA Gene Model | MGI Sequence Detail	913054	C57BL/6J
transcript	OTTMUST00000075829	VEGA | MGI Sequence Detail	2244	Not Applicable
polypeptide	OTTMUSP00000039818	VEGA | MGI Sequence Detail	414	Not Applicable

All sequences(56) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(5596 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002347	Glucose/ribitol dehydrogenase
InterPro	IPR016040	NAD(P)-binding domain
InterPro	IPR002198	Short-chain dehydrogenase/reductase SDR
InterPro	IPR001202	WW/Rsp5/WWP
Protein Ontology	PR:000001036	WW domain-containing oxidoreductase

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:187255 Ferguson BW, et al., Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches. PLoS One. 2012;7(5):e36618
All references(51)

Other accession IDs

MGI:1918787, MGI:1925520