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Zbtb20 Gene Detail
Summary
  • Symbol
    Zbtb20
  • Name
    zinc finger and BTB domain containing 20
  • Synonyms
    1300017A20Rik, 7330412A13Rik, A930017C21Rik, D16Wsu73e, HOF, Zfp288
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929213
    NCBI Gene: 56490
  • Gene Overview
    MyGene.info: ZBTB20
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:42875881-43642602 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      766722 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 28.44 cM, cytoband B4
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    ZBTB20, zinc finger and BTB domain containing 20
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZBTB20, zinc finger and BTB domain containing 20
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DPZF, HOF, ODA-8S, PRIMS, ZNF288
  • Links
    NCBI Gene ID: 26137
    neXtProt AC: NX_Q9HC78
    UniProt: Q9HC78

  • Chr Location
    3q13.31; chr3:114314500-115147280 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9226
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZBTB20
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 3 alleles in 3 genetic backgrounds
    30 phenotypes from multigenic genotypes
    173 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit growth retardation, disrupted homeostasis, and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000025618 VEGA Gene Model | MGI Sequence Detail 766722 C57BL/6J ±  kb
    transcript OTTMUST00000062820 VEGA | MGI Sequence Detail 26901 Not Applicable  
    polypeptide OTTMUSP00000031038 VEGA | MGI Sequence Detail 741 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      3023 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 24
      Primer pair 3

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-33985, MGI:106293, MGI:1915064, MGI:1925393, MGI:1925687, MGI:3057146
    References
    more
    • Summaries
      All 220
      Developmental Gene Expression 25
      Diseases 2
      Gene Ontology 7
      Phenotypes 173
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:261269 Martinez-Losa M, et al., Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease. Neuron. 2018 Apr 4;98(1):75-89.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory