30 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apoetm1Unc/Apoetm2(APOE_i3)Yhg Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2	amyloid beta deposits	J:184138
Apoetm1Unc/Apoetm3(APOE_i4)Yhg Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2	amyloid beta deposits	J:184138
C3tm1Crr/C3tm1Crr Zbtb20Tg(PDGFB-APPSwInd)20Lms/? involves: 129S4/SvJae * C57BL/6	amyloid beta deposits	J:135902
	increased microglial cell activation	J:135902
	loss of hippocampal neurons	J:135902
Mapttm1Hnd/Mapt+ Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 involves: 129X1/SvJ * C57BL/6 * DBA/2	abnormal neuron differentiation	J:121330
	abnormal neuron morphology	J:121330
	abnormal spatial learning	J:121330
	amyloid beta deposits	J:121330
	normal behavior/neurological phenotype	J:121330
	decreased susceptibility to pharmacologically induced seizures	J:121330
Mapttm1Hnd/Mapttm1Hnd Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 involves: 129X1/SvJ * C57BL/6 * DBA/2	abnormal neuron differentiation	J:121330
	abnormal neuron morphology	J:121330
	amyloid beta deposits	J:121330
	normal behavior/neurological phenotype	J:121330
	decreased susceptibility to pharmacologically induced seizures	J:121330
Pla2g4atm1Jvb/Pla2g4a+ Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 involves: 129S4/SvJae * C57BL/6 * DBA/2	abnormal spatial learning	J:141084
	normal behavior/neurological phenotype	J:141084
	decreased anxiety-related response	J:141084
	normal mortality/aging	J:141084
Pla2g4atm1Jvb/Pla2g4atm1Jvb Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 involves: 129S4/SvJae * C57BL/6 * DBA/2	abnormal spatial learning	J:141084
	normal behavior/neurological phenotype	J:141084
	decreased anxiety-related response	J:141084
	normal mortality/aging	J:141084
Psen1tm4.1Shn/Psen1+ Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 involves: 129 * C57BL/6 * C57BL/6J * DBA/2	amyloid beta deposits	J:219929
Tg(Camk2a-IDE)1Selk/0 Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 involves: C57BL/6 * DBA/2	abnormal neurite morphology	J:87150
	amyloid beta deposits	J:87150
	astrocytosis	J:87150
	gliosis	J:87150
	premature death	J:87150
Tg(Camk2a-MME)3Selk/0 Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 involves: C57BL/6 * DBA/2	abnormal neurite morphology	J:87150
	amyloid beta deposits	J:87150
	astrocytosis	J:87150
	gliosis	J:87150
	premature death	J:87150
Tg(Camk2a-tTA)1Mmay/0 Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 Tg(tetO-MAPT)32Lms/0 involves: C57BL/6 * C57BL/6J * DBA/2	lethality, incomplete penetrance	J:233816
	premature death	J:233816
Tg(Camk2a-tTA)1Mmay/0 Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 Tg(tetO-MAPT*A152T)L1Lms/0 involves: C57BL/6 * C57BL/6J * DBA/2	lethality at weaning	J:233816
	preweaning lethality, incomplete penetrance	J:233816
Tg(Gfap-TGFB1)64Lms/0 Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 involves: BALB/c * C57BL/6 * DBA/2 * SJL	abnormal blood vessel morphology	J:167619
	abnormal brain pia mater morphology	J:167619
	abnormal brain vasculature morphology	J:167619
	abnormal cholinergic neuron morphology	J:167619
	abnormal somatosensory cortex physiology	J:167619
	abnormal spatial learning	J:167619
	abnormal spatial reference memory	J:167619
	amyloid beta deposits	J:167619
	astrocytosis	J:167619
	cerebral amyloid angiopathy	J:167619
	decreased vasodilation	J:167619
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 B6.Cg-Zbtb20Tg(PDGFB-APPSwInd)20Lms	abnormal cerebral cortex pyramidal cell morphology	J:118589
	abnormal neurite morphology	J:100954
	amyloid beta deposits	J:100954
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 involves: C57BL/6 * DBA/2	abnormal long-term object recognition memory	J:121330
	abnormal neuron differentiation	J:121330
	abnormal neuron morphology	J:121330
	abnormal spatial learning	J:121330, J:141084
	amyloid beta deposits	J:62290, J:87150, J:121330
	decreased anxiety-related response	J:141084
	hyperactivity	J:121330, J:141084
	increased susceptibility to pharmacologically induced seizures	J:121330
	neurodegeneration	J:62290
	premature death	J:87150, J:121330, J:141084