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Htra1
Gene Detail
 Symbol
Name
ID
Htra1
HtrA serine peptidase 1
MGI:1929076
Synonyms HtrA1, insulin-like growth factor binding protein 5 protease, L56, Prss11, RSPP11
Feature Type protein coding gene
Genetic Map
Chromosome 7
73.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:130936111-130985660 bp, + strand
From VEGA annotation of GRCm38

  49550 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31114  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: serine protease, HTRA type
Gene Tree: Htra1

Human
homologs
Human Homolog HTRA1, HtrA serine peptidase 1
NCBI Gene ID 5654
neXtProt AC  NX_Q92743
Human Synonyms  ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11
Human Chr (Location)  10q26.3; chr10:122461525-122514908 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human HTRA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(26) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal retinal morphology. Mice homozygous for a different allele exhibit increased bone volume and increased trabecular bone thickness without body weight gain.
 
Phenotype Images(1)
Interactions
Htra1 interacts with 93 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process negative regulation of BMP signaling pathway, negative regulation of defense response to virus, ...
Component cytoplasm, extracellular matrix, ...
Function catalytic activity, growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (253)    Tissues (88)    Images (41)
Theiler Stages: 4, 5, 11, 12, 13, 14, 15, 21, 23, 24
Assay TypeResults
RNA in situ 244
RT-PCR 9
cDNA source data(99)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(102) cDNA(99) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031663 (Evidence)
Ensembl Gene ModelENSMUSG00000006205 (Evidence)
Entrez Gene56213 (Evidence)
UniGene30156
DFCITC1575172
DoTSDT.111000167, DT.535056, DT.97383603
NIA Mouse Gene IndexU008850
EC3.4.21.-
Consensus CDS ProjectCCDS21908.1
International Mouse Knockout Project StatusHtra1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031663 VEGA Gene Model | MGI Sequence Detail 49550 C57BL/6J ±  kb
transcript OTTMUST00000078440 VEGA | MGI Sequence Detail 2041 Not Applicable 
polypeptide OTTMUSP00000041705 VEGA | MGI Sequence Detail 480 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(355 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR002350 Kazal domain
InterPro IPR001478 PDZ domain
InterPro IPR001940 Peptidase S1C
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000008838 serine protease HTRA1
References (Earliest) J:64479 Gray CW, et al., Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. Eur J Biochem. 2000 Sep;267(18):5699-710
(Latest) J:210417 Supanji, et al., HtrA1 is induced by oxidative stress and enhances cell senescence through p38 MAPK pathway. Exp Eye Res. 2013 Jul;112:79-92
All references(59)
Other
accession IDs
MGI:2141952

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory