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Htra1 Gene Detail
Summary
  • Symbol
    Htra1
  • Name
    HtrA serine peptidase 1
  • Synonyms
    HtrA1, insulin-like growth factor binding protein 5 protease, L56, Prss11, RSPP11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929076
    NCBI Gene: 56213
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:130537933-130587388 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 73.20 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2641 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929076
 protein coding gene Chr7:130537841-130587390 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033096
 protein coding gene Chr7:135497291-135554124 (+)
A/J MGP_AJ_G0033078
 protein coding gene Chr7:131788799-131838251 (+)
AKR/J MGP_AKRJ_G0033010
 protein coding gene Chr7:135292794-135343850 (+)
BALB/cJ MGP_BALBcJ_G0033079
 protein coding gene Chr7:131487611-131537150 (+)
C3H/HeJ MGP_C3HHeJ_G0032793
 protein coding gene Chr7:135159386-135209808 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033589
 protein coding gene Chr7:140702596-140755365 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030561
 protein coding gene Chr7:132946278-132996262 (+)
CAST/EiJ MGP_CASTEiJ_G0032123
 protein coding gene Chr7:126981491-127033160 (+)
CBA/J MGP_CBAJ_G0032766
 protein coding gene Chr7:145520423-145572837 (+)
DBA/2J MGP_DBA2J_G0032918
 protein coding gene Chr7:129791444-129841656 (+)
FVB/NJ MGP_FVBNJ_G0032871
 protein coding gene Chr7:129644212-129694309 (+)
LP/J MGP_LPJ_G0033012
 protein coding gene Chr7:136971919-137024502 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032903
 protein coding gene Chr7:146455490-146508192 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033610
 protein coding gene Chr7:134277187-134329612 (+)
PWK/PhJ MGP_PWKPhJ_G0031829
 protein coding gene Chr7:122861080-122912109 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031675
 protein coding gene Chr7:121045693-121096866 (+)
WSB/EiJ MGP_WSBEiJ_G0032234
 protein coding gene Chr7:135221814-135274404 (+)



Homology
more
  • Human Ortholog
    HTRA1, HtrA serine peptidase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTRA1, HtrA serine peptidase 1
  • Synonyms
    ARMD7, CADASIL2, CARASIL, HtrA, L56, ORF480, PRSS11
  • Links
    NCBI Gene ID: 5654
    UniProt: Q92743

  • Chr Location
    10q26.13; chr10:122458551-122514907 (+)  GRCh38
Human Diseases
more
  • Diseases
    11 with human HTRA1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal retinal morphology. Mice homozygous for a different allele exhibit increased bone volume and increased trabecular bone thickness without body weight gain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1125
  • Tissues
    230
  • cDNA Data
    101
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56213 NCBI Gene Model | MGI Sequence Detail 49456 C57BL/6J ±  kb
    transcript NM_019564 RefSeq | MGI Sequence Detail 2051 C57BL/6  
    polypeptide Q9R118 UniProt | EBI | MGI Sequence Detail 480 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 102
      Primer pair 6
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141952
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 25
      Gene Ontology 12
      Phenotypes 28
    • Earliest
      J:64479 Gray CW, et al., Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. Eur J Biochem. 2000 Sep;267(18):5699-710
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory