About   Help   FAQ
Htra1 Gene Detail
Summary
  • Symbol
    Htra1
  • Name
    HtrA serine peptidase 1
  • Synonyms
    HtrA1, insulin-like growth factor binding protein 5 protease, L56, Prss11, RSPP11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929076
    NCBI Gene: 56213
  • Gene Overview
    MyGene.info: HTRA1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:130936111-130985660 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      49550 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 73.20 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HTRA1, HtrA serine peptidase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HTRA1, HtrA serine peptidase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARMD7, CADASIL2, CARASIL, HtrA, L56, ORF480, PRSS11
  • Links
    NCBI Gene ID: 5654
    neXtProt AC: NX_Q92743
    UniProt: Q92743

  • Chr Location
    10q26.13; chr10:122461525-122514908 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    3 with human HTRA1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    7 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal retinal morphology. Mice homozygous for a different allele exhibit increased bone volume and increased trabecular bone thickness without body weight gain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    270
  • Tissues
    98
  • cDNA Data
    99
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031663 VEGA Gene Model | MGI Sequence Detail 49550 C57BL/6J ±  kb
    transcript OTTMUST00000078440 VEGA | MGI Sequence Detail 2041 Not Applicable  
    polypeptide OTTMUSP00000041705 VEGA | MGI Sequence Detail 480 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      347 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 103
      cDNA 99
      Primer pair 2
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141952
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 18
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:64479 Gray CW, et al., Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. Eur J Biochem. 2000 Sep;267(18):5699-710
    • Latest
      J:261197 Chen J, et al., BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response. J Neurosci. 2018 Apr 11;38(15):3840-3857
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    06/19/2018
    MGI 6.12     		The Jackson Laboratory