Htra1
Gene Detail

Symbol Name ID

Htra1 HtrA serine peptidase 1 MGI:1929076

Synonyms

HtrA1, insulin-like growth factor binding protein 5 protease, L56, Prss11, RSPP11

Feature Type

protein coding gene

Genetic Map

Chromosome 7

73.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:130936111-130985660 bp, + strand From VEGA annotation of GRCm38   49550 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31114  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 2 zebrafish

Protein SuperFamily: serine protease, HTRA type
Gene Tree: Htra1

Human homologs

Human Homolog		HTRA1, HtrA serine peptidase 1
NCBI Gene ID		5654
neXtProt AC		NX_Q92743
Human Synonyms		ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11
Human Chr (Location)		10q26.3; chr10:122461525-122514908 (+)  GRCh38
Disease Associations		(2) Diseases Associated with Human HTRA1

Mutations, alleles, and phenotypes

All mutations/alleles(32) : Gene trapped(26) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit normal retinal morphology. Mice homozygous for a different allele exhibit increased bone volume and increased trabecular bone thickness without body weight gain.

 
Phenotype Images(1)

Interactions

Htra1 interacts with 93 markers (Mir7-2, Mir7b, Mir9-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	negative regulation of BMP signaling pathway, negative regulation of defense response to virus, ...
Component	cytoplasm, extracellular matrix, ...
Function	catalytic activity, growth factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)

Data Summary: Results (253)    Tissues (88)    Images (41)
Theiler Stages: 4, 5, 11, 12, 13, 14, 15, 21, 23, 24

Assay Type	Results
RNA in situ	244
RT-PCR	9

cDNA source data(99)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(102) cDNA(99) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000031663 (Evidence)
Ensembl Gene Model	ENSMUSG00000006205 (Evidence)
Entrez Gene	56213 (Evidence)
UniGene	30156
DFCI	TC1575172
DoTS	DT.111000167, DT.535056, DT.97383603
NIA Mouse Gene Index	U008850
EC	3.4.21.-
Consensus CDS Project	CCDS21908.1
International Mouse Knockout Project Status	Htra1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031663	VEGA Gene Model | MGI Sequence Detail	49550	C57BL/6J
transcript	OTTMUST00000078440	VEGA | MGI Sequence Detail	2041	Not Applicable
polypeptide	OTTMUSP00000041705	VEGA | MGI Sequence Detail	480	Not Applicable

All sequences(35) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(355 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000867	Insulin-like growth factor-binding protein, IGFBP
InterPro	IPR009030	Insulin-like growth factor binding protein, N-terminal
InterPro	IPR002350	Kazal domain
InterPro	IPR001478	PDZ domain
InterPro	IPR001940	Peptidase S1C
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000008838	serine protease HTRA1

References

(Earliest) J:64479 Gray CW, et al., Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. Eur J Biochem. 2000 Sep;267(18):5699-710
(Latest) J:210417 Supanji, et al., HtrA1 is induced by oxidative stress and enhances cell senescence through p38 MAPK pathway. Exp Eye Res. 2013 Jul;112:79-92
All references(59)

Other accession IDs

MGI:2141952