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Stk4 Gene Detail
Summary
  • Symbol
    Stk4
  • Name
    serine/threonine kinase 4
  • Synonyms
    Kas-2, Mst1, sterile 20-like kinase 1, Ysk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929004
    NCBI Gene: 58231
Location & Maps
more
  • Sequence Map
    Chr2:164070322-164155524 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      85203 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    STK4, serine/threonine kinase 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    STK4, serine/threonine kinase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KRS2, MST1, TIIAC, YSK3
  • Links
    NCBI Gene ID: 6789
    neXtProt AC: NX_Q13043

  • Chr Location
    20q11.2-q13.2; chr20:44966479-45079975 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55965
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: STK4
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human STK4 associations

Human Disease Mouse Models
       T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations; TIIAC   OMIM: 614868
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 7 alleles in 9 genetic backgrounds
    69 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    52
  • Chemically induced (ENU)
    1
  • Gene trapped
    38
  • Targeted
    13
  • Incidental Mutations
Mice homozygous for a gene trap allele have low numbers of na´ve T cells that are hyper-responsive to stimulation. Mice homozygous for knock-out alleles exhibit decreased peripheral T cell numbers due to impaired emigration and homing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001179 VEGA Gene Model | MGI Sequence Detail 85203 C57BL/6J ±  kb
transcript OTTMUST00000002310 VEGA | MGI Sequence Detail 5232 Not Applicable  
polypeptide OTTMUSP00000001138 VEGA | MGI Sequence Detail 487 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    497 from dbSNP Build 137
Protein
Information
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Molecular
Reagents
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  • All nucleic 135
    cDNA 135

    Microarray probesets 5
Other
Accession IDs
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MGI:1203525, MGI:2138944, MGI:2139225
References
more
  • Summaries
    All 81
    Developmental Gene Expression 8
    Gene Ontology 14
    Phenotypes 43
  • Earliest
    J:29051 Bagrodia S, et al., Identification of a mouse p21Cdc42/Rac activated kinase [published erratum appears in J Biol Chem 1996 Jan 12;271(2):1250]. J Biol Chem. 1995 Sep 29;270(39):22731-7
  • Latest
    J:227481 Li W, et al., STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma. J Clin Invest. 2015 Nov 2;125(11):4239-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory