Stk4
Gene Detail

Symbol Name ID

Stk4 serine/threonine kinase 4 MGI:1929004

Synonyms

Kas-2, Mst1, sterile 20-like kinase 1, Ysk3

Feature Type

protein coding gene

Genetic Map

Chromosome 2

84.60 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:164070322-164155524 bp, + strand From VEGA annotation of GRCm38   85203 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55965  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Stk4

Human homologs

Human Homolog		STK4, serine/threonine kinase 4
NCBI Gene ID		6789
neXtProt AC		NX_Q13043
Human Synonyms		KRS2, MST1, TIIAC, YSK3
Human Chr (Location)		20q11.2-q13.2; chr20:43595120-43708594 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human STK4

Alleles and phenotypes

All alleles(49) : Targeted(11) Gene trapped(38)
 

Mice homozygous for a gene trap allele have low numbers of nave T cells that are hyper-responsive to stimulation. Mice homozygous for knock-out alleles exhibit decreased peripheral T cell numbers due to impaired emigration and homing.

 

Gene Ontology (GO) classifications

All GO classifications: (46 annotations)

Process	apoptotic process, cell differentiation involved in embryonic placenta development, ...
Component	cytoplasm, nucleus
Function	ATP binding, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(125)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(125) cDNA(125)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000001179 (Evidence)
Ensembl Gene Model	ENSMUSG00000018209 (Evidence)
Entrez Gene	58231 (Evidence)
UniGene	479158
DFCI	TC1579558, TC1601765, TC1630767
DoTS	DT.526365, DT.94360939
EC	2.7.11.1
Consensus CDS Project	CCDS17021.1
International Mouse Knockout Project Status	Stk4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001179	VEGA Gene Model | MGI Sequence Detail	85203	C57BL/6J
transcript	OTTMUST00000002310	VEGA | MGI Sequence Detail	5232	Not Applicable
polypeptide	OTTMUSP00000001138	VEGA | MGI Sequence Detail	487	Not Applicable

All sequences(47) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(426 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024205	Mst1 SARAH domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR011524	SARAH domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
Protein Ontology	PR:000015757	serine/threonine-protein kinase 4

References

(Earliest) J:29051 Bagrodia S, et al., Identification of a mouse p21Cdc42/Rac activated kinase [published erratum appears in J Biol Chem 1996 Jan 12;271(2):1250]. J Biol Chem. 1995 Sep 29;270(39):22731-7
(Latest) J:195266 Reginensi A, et al., Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development. PLoS Genet. 2013 Mar;9(3):e1003380
All references(66)

Other accession IDs

MGI:1203525, MGI:2138944, MGI:2139225