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Stk4 Gene Detail
Summary
  • Symbol
    Stk4
  • Name
    serine/threonine kinase 4
  • Synonyms
    Kas-2, Mst1, sterile 20-like kinase 1, Ysk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929004
    NCBI Gene: 58231
  • Gene Overview
    MyGene.info: STK4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164074113-164155521 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 84.60 cM, cytoband H3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    495 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929004
protein coding gene Chr2:164070322-164155524 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026836
protein coding gene Chr2:169449281-169547130 (+)
A/J MGP_AJ_G0026802
protein coding gene Chr2:162594845-162679556 (+)
AKR/J MGP_AKRJ_G0026773
protein coding gene Chr2:167411525-167502380 (+)
BALB/cJ MGP_BALBcJ_G0026811
protein coding gene Chr2:162935069-163022223 (+)
C3H/HeJ MGP_C3HHeJ_G0026553
protein coding gene Chr2:167763479-167856490 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027259
protein coding gene Chr2:174394694-174481896 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024629
protein coding gene Chr2:155903854-155990781 (+)
CAST/EiJ MGP_CASTEiJ_G0026014
protein coding gene Chr2:168179040-168279202 (+)
CBA/J MGP_CBAJ_G0026530
protein coding gene Chr2:180667236-180767642 (+)
DBA/2J MGP_DBA2J_G0026668
protein coding gene Chr2:161764161-161849298 (+)
FVB/NJ MGP_FVBNJ_G0026634
protein coding gene Chr2:160141240-160227480 (+)
LP/J MGP_LPJ_G0026771
protein coding gene Chr2:169557424-169647453 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026656
protein coding gene Chr2:184336070-184429491 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027315
protein coding gene Chr2:167312460-167402737 (+)
PWK/PhJ MGP_PWKPhJ_G0025748
protein coding gene Chr2:161337522-161427564 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025551
protein coding gene Chr2:166191419-166277199 (+)
WSB/EiJ MGP_WSBEiJ_G0026084
protein coding gene Chr2:168176712-168268214 (+)



Homology
more
  • Human Ortholog
    STK4, serine/threonine kinase 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    STK4, serine/threonine kinase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KRS2, MST1, YSK3
  • Links
    NCBI Gene ID: 6789
    neXtProt AC: NX_Q13043
    UniProt: Q13043

  • Chr Location
    20q13.12; chr20:44966474-45079977 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55965
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: STK4
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 10 alleles in 12 genetic backgrounds
    69 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele have low numbers of nave T cells that are hyper-responsive to stimulation. Mice homozygous for knock-out alleles exhibit decreased peripheral T cell numbers due to impaired emigration and homing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58231 NCBI Gene Model | MGI Sequence Detail 81409 C57BL/6J ±  kb
    transcript NM_021420 RefSeq | MGI Sequence Detail 5246 C57BL/6  
    polypeptide Q9JI11 UniProt | EBI | MGI Sequence Detail 487 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 136
      cDNA 136

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1203525, MGI:2138944, MGI:2139225
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 17
      Phenotypes 73
    • Earliest
      J:29051 Bagrodia S, et al., Identification of a mouse p21Cdc42/Rac activated kinase [published erratum appears in J Biol Chem 1996 Jan 12;271(2):1250]. J Biol Chem. 1995 Sep 29;270(39):22731-7
    • Latest
      J:265555 Oristian KM, et al., Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis. Cancer Res. 2018 Oct 1;78(19):5513-5520

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory