Mtor
Gene Detail

Symbol Name ID

Mtor mechanistic target of rapamycin (serine/threonine kinase) MGI:1928394

Synonyms

2610315D21Rik, FKBP-rapamycin-associated protein FRAP, flat, Frap1, RAFT1, RAPT1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

78.76 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr4:148448611-148557683 bp, + strand From VEGA annotation of GRCm38   109073 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3637  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mtor

Human homologs

Human Homolog		MTOR, mechanistic target of rapamycin (serine/threonine kinase)
NCBI Gene ID		2475
neXtProt AC		NX_P42345
Human Synonyms		FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Human Chr (Location)		1p36.2; chr1:11166588-11322608 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(25) : Targeted(12) Gene trapped(12) Chemically induced(1)
 

Mice homozygous for targeted, gene trap and ENU-induced null alleles exhibit embryonic lethality by E12.5 with abnormal embryogenesis. Mice homozygous for the ENU mutation further exhibit abnormal brain development.

 

Gene Ontology (GO) classifications

All GO classifications: (88 annotations)

Process	cell growth, cell projection organization, ...
Component	cytoplasm, cytosol, ...
Function	ATP binding, drug binding, ...

External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (50)    Tissues (31)    Images (18)
Theiler Stages: 19, 23, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	27
Western blot	16

cDNA source data(145)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(147) cDNA(146) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000010950 (Evidence)
Ensembl Gene Model	ENSMUSG00000028991 (Evidence)
Entrez Gene	56717 (Evidence)
UniGene	21158
DFCI	TC1572272, TC1587534, TC1662972
DoTS	DT.101243693, DT.490327, DT.91355852, DT.94341014, DT.94341015
NIA Mouse Gene Index	U005086
EC	2.7.11.1
Consensus CDS Project	CCDS18937.1
International Mouse Knockout Project Status	Mtor

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010950	VEGA Gene Model | MGI Sequence Detail	109073	C57BL/6J
transcript	OTTMUST00000025684	VEGA | MGI Sequence Detail	8564	Not Applicable
polypeptide	OTTMUSP00000011776	VEGA | MGI Sequence Detail	2549	Not Applicable

All sequences(42) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(761 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR024585	Domain of unknown function DUF3385, target of rapamycin protein
InterPro	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
InterPro	IPR014009	PIK-related kinase
InterPro	IPR003151	PIK-related kinase, FAT
InterPro	IPR003152	PIK-related kinase, FATC
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR009076	Rapamycin-binding domain
InterPro	IPR026683	Serine/threonine-protein kinase TOR/Smg1
Protein Ontology	PR:000003041	serine/threonine-protein kinase mTOR

References

(Earliest) J:155370 Cohen JS, Provide fluoxetine information vital to clinicians. J Clin Psychiatry. 1995 Dec;56(12):591
(Latest) J:193238 Katholnig K, et al., p38alpha Senses Environmental Stress To Control Innate Immune Responses via Mechanistic Target of Rapamycin. J Immunol. 2013 Feb 15;190(4):1519-27
All references(156)

Other accession IDs

MGI:1332655, MGI:1919780, MGI:2140250