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Mtor Gene Detail
Summary
  • Symbol
    Mtor
  • Name
    mechanistic target of rapamycin (serine/threonine kinase)
  • Synonyms
    2610315D21Rik, FKBP-rapamycin-associated protein FRAP, flat, Frap1, RAFT1, RAPT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928394
    NCBI Gene: 56717
  • Gene Overview
    MyGene.info: MTOR
Location & Maps
more
  • Sequence Map
    Chr4:148448611-148557683 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      109073 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.76 cM, cytoband E1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    MTOR, mechanistic target of rapamycin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MTOR, mechanistic target of rapamycin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS
  • Links
    NCBI Gene ID: 2475
    neXtProt AC: NX_P42345

  • Chr Location
    1p36.22; chr1:11106531-11262557 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3637
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MTOR
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MTOR associations

Human Disease Mouse Models
       Smith-Kingsmore Syndrome; SKS   OMIM: 616638
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    134 phenotypes from 14 alleles in 15 genetic backgrounds
    26 phenotypes from multigenic genotypes
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (ENU)
    2
  • Gene trapped
    12
  • Targeted
    15
  • Transgenic
    2
  • Genomic Mutations
    1 involving Mtor
  • Incidental Mutations
Mice homozygous for targeted, gene trap and ENU-induced null alleles exhibit embryonic lethality by E12.5 with abnormal embryogenesis. Mice homozygous for the ENU mutation further exhibit abnormal brain development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010950 VEGA Gene Model | MGI Sequence Detail 109073 C57BL/6J ±  kb
transcript OTTMUST00000025684 VEGA | MGI Sequence Detail 8564 Not Applicable  
polypeptide OTTMUSP00000011776 VEGA | MGI Sequence Detail 2549 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1059 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 149
    cDNA 147
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGI:1332655, MGI:1919780, MGI:2140250
References
more
  • Summaries
    All 219
    Developmental Gene Expression 32
    Gene Ontology 34
    Phenotypes 56
  • Earliest
    J:155370 Cohen JS, Provide fluoxetine information vital to clinicians. J Clin Psychiatry. 1995 Dec;56(12):591
  • Latest
    J:236498 Boyer A, et al., mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice. Biol Reprod. 2016 Jul;95(1):13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory