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Mtor
Gene Detail
Symbol

Name
ID
Mtor
mechanistic target of rapamycin (serine/threonine kinase)
MGI:1928394
Synonyms
2610315D21Rik, FKBP-rapamycin-associated protein FRAP, flat, Frap1, RAFT1, RAPT1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
78.76 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:148448611-148557683 bp, + strand
From VEGA annotation of GRCm38

  109073 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3637  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mtor

Human
homologs
Human Homolog MTOR, mechanistic target of rapamycin (serine/threonine kinase)
NCBI Gene ID 2475
neXtProt AC  NX_P42345
Human Synonyms  FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Human Chr (Location)  1p36.2; chr1:11106531-11262557 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Chemically induced (ENU)(2) Gene trapped(12) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted, gene trap and ENU-induced null alleles exhibit embryonic lethality by E12.5 with abnormal embryogenesis. Mice homozygous for the ENU mutation further exhibit abnormal brain development.
 
Interactions
Mtor interacts with 234 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (97 annotations)
Process cell growth, cell projection organization, ...
Component cytoplasm, cytosol, ...
Function ATP binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (50)    Tissues (31)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 27
Western blot 16
cDNA source data(146)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(148) cDNA(147) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000010950 (Evidence)
Ensembl Gene ModelENSMUSG00000028991 (Evidence)
Entrez Gene56717 (Evidence)
UniGene21158
DFCITC1587534, TC1572272, TC1662972
DoTSDT.101243693, DT.94341014, DT.91355852, DT.94341015, DT.490327
NIA Mouse Gene IndexU005086
EC2.7.11.1
Consensus CDS ProjectCCDS18937.1
International Mouse Knockout Project StatusMtor
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010950 VEGA Gene Model | MGI Sequence Detail 109073 C57BL/6J ±  kb
transcript OTTMUST00000025684 VEGA | MGI Sequence Detail 8564 Not Applicable 
polypeptide OTTMUSP00000011776 VEGA | MGI Sequence Detail 2549 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(1091 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR024585 Domain of unknown function DUF3385, target of rapamycin protein
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR014009 PIK-related kinase
InterPro IPR003151 PIK-related kinase, FAT
InterPro IPR003152 PIK-related kinase, FATC
InterPro IPR011009 Protein kinase-like domain
InterPro IPR009076 Rapamycin-binding domain
InterPro IPR011990 Tetratricopeptide-like helical
Protein Ontology PR:000003041 serine/threonine-protein kinase mTOR
References
(Earliest) J:155370 Cohen JS, Provide fluoxetine information vital to clinicians. J Clin Psychiatry. 1995 Dec;56(12):591
(Latest) J:213870 Chen J, et al., mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis. Development. 2014 Jul;141(14):2848-54
All references(190)
Other
accession IDs
MGI:1332655, MGI:1919780, MGI:2140250

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory