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Gene Detail
solute carrier family 4 (anion exchanger), member 4
Synonyms NBC, NBC1
Feature Type protein coding gene
Genetic Map
Chromosome 5
44.10 cM, cytoband E2
Detailed Genetic Map ± 1 cM

Mapping data(3)
Sequence Map
Chr5:88886818-89239653 bp, + strand
From VEGA annotation of GRCm38

  352836 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:55776  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: band 3-like protein
Gene Tree: Slc4a4

Human Homolog SLC4A4, solute carrier family 4 (sodium bicarbonate cotransporter), member 4
NCBI Gene ID 8671
neXtProt AC  NX_Q9Y6R1
Human Synonyms  hhNMC, HNBC1, KNBC, NBC1, NBC2, NBCe1-A, pNBC, SLC4A5
Human Chr (Location)  4q21; chr4:71092756-71572087 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC4A4
alleles, and
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a null allele exhibit smaller birth size, growth retardation, postnatal lethality, bowel obstructions, altered blood chemistry, acidosis, spleen defects and defects in ion homeostasis. Heterozygotes have decreased levels of circulating bicarbonate.
Human Diseases Modeled Using Mouse Slc4a4 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)
Slc4a4 interacts with 480 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
All GO classifications: (24 annotations)
Process anion transport, bicarbonate transport, ...
Component extracellular vesicular exosome, integral component of membrane, ...
Function anion transmembrane transporter activity, inorganic anion exchanger activity, ...
External Resources: FuncBase
Literature Summary: (6 records)
Data Summary: Results (63)    Tissues (41)    Images (18)
Theiler Stages: 11, 13, 23, 26, 28
Assay TypeResults
RNA in situ 63
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(18) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(8)
Other database
VEGA Gene ModelOTTMUSG00000025881 (Evidence)
Ensembl Gene ModelENSMUSG00000060961 (Evidence)
Entrez Gene54403 (Evidence)
DFCITC1586481, TC1637521, TC1641396
DoTSDT.91569891, DT.97409209
NIA Mouse Gene IndexU040642
Consensus CDS ProjectCCDS19406.1, CCDS51541.1, CCDS57352.1
International Mouse Knockout Project StatusSlc4a4
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025881 VEGA Gene Model | MGI Sequence Detail 352836 C57BL/6J ±  kb
transcript OTTMUST00000063777 VEGA | MGI Sequence Detail 3494 Not Applicable 
polypeptide OTTMUSP00000031585 VEGA | MGI Sequence Detail 1094 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(22) UniProt(8)
Polymorphisms SNPs within 2kb(2627 from dbSNP Build 137)
InterPro IPR013769 Band 3 cytoplasmic domain
InterPro IPR011531 Bicarbonate transporter, C-terminal
InterPro IPR003020 Bicarbonate transporter, eukaryotic
InterPro IPR016152 Phosphotransferase/anion transporter
InterPro IPR003024 Sodium bicarbonate cotransporter
Protein Ontology PR:000015160 electrogenic sodium bicarbonate cotransporter 1
References (Earliest) J:62645 Abuladze N, et al., Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter. J Biol Chem. 1998 Jul 10;273(28):17689-95
(Latest) J:186877 Lo YF, et al., Severe metabolic acidosis causes early lethality in NBC1 W516X knock-in mice as a model of human isolated proximal renal tubular acidosis. Kidney Int. 2011 Apr;79(7):730-41
All references(45)
Disease annotation references (2)
accession IDs

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory