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Zbp1
Gene Detail
Symbol

Name
ID
Zbp1
Z-DNA binding protein 1
MGI:1927449
Synonyms
2010010H03Rik, Dai, mZaDLM
Feature Type
protein coding gene
Genetic Map
Chromosome 2
95.83 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:173206612-173218923 bp, - strand
From VEGA annotation of GRCm38

  12312 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10972  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: ZBP1
Gene Tree: Zbp1

Human
homologs
ZBP1, Z-DNA binding protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 81030
neXtProt AC: NX_Q9H171

Human Synonyms: C20orf183, DAI, DLM1, DLM-1

Human Chr (Location): 20q13.31; chr20:57603846-57620576 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele display normal innate immune activation by double-stranded B-form DNA (B-DNA) as well as normal adaptive immune responses to DNA vaccination.
 
Interactions
Zbp1 interacts with 146 markers (Mir16-1, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process defense response to virus, immune system process, ...
Component cytoplasm, cytosol, ...
Function DNA binding, double-stranded RNA adenosine deaminase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) cDNA(35)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016683 (Evidence)
Ensembl Gene Model ENSMUSG00000027514 (Evidence)
Entrez Gene 58203 (Evidence)
UniGene 116687
DFCI TC1581696, TC1588136
DoTS DT.99843550, DT.99843551, DT.530627, DT.55260990
NIA Mouse Gene Index U023727
PDB 2HEO, 1J75
Consensus CDS Project CCDS17142.1, CCDS50813.1
International Mouse Phenotyping Consortium Status Zbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016683 VEGA Gene Model | MGI Sequence Detail 12312 C57BL/6J ±  kb
transcript OTTMUST00000040401 VEGA | MGI Sequence Detail 1989 Not Applicable 
polypeptide OTTMUSP00000018050 VEGA | MGI Sequence Detail 411 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000607 Double-stranded RNA-specific adenosine deaminase (DRADA)
InterPro IPR025735 RHIM domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000017560 Z-DNA-binding protein 1
References
(Earliest) J:58659 Fu Y, et al., Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display. Gene. 1999 Nov 15;240(1):157-63
(Latest) J:213251 Imanishi T, et al., Nucleic acid sensing by T cells initiates Th2 cell differentiation. Nat Commun. 2014;5:3566
All references(43)
Other
accession IDs
MGI:1917117

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory