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Sequence Detail
Q9QY24 Q8VE02 Q9D8B9 (UniProt | EBI) Last sequence update: 2000-05-01
Last annotation update: 2024-05-29
from provider
RecName: Full=Z-DNA-binding protein 1 {ECO:0000303|PubMed:17618271};AltName: Full=DNA-dependent activator of IFN-regulatory factors {ECO:0000303|PubMed:17618271}; Short=DAI {ECO:0000303|PubMed:17618271};AltName: Full=Tumor stroma and activated mac
Polypeptide 411 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Zbp1 Z-DNA binding protein 1 35 97 2 21
Sequence references in MGI J:58659 Fu Y, et al., Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display. Gene. 1999 Nov 15;240(1):157-63
J:74605 Schwartz T, et al., Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins. Nat Struct Biol. 2001 Sep;8(9):761-5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:123411 Takaoka A, et al., DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature. 2007 Jul 26;448(7152):501-5
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:157332 Rebsamen M, et al., DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep. 2009 Aug;10(8):916-22
J:242990 Newton K, et al., RIPK1 inhibits ZBP1-driven necroptosis during development. Nature. 2016 Dec 01;540(7631):129-133
J:242991 Lin J, et al., RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016 Dec 01;540(7631):124-128
J:244643 Kesavardhana S, et al., ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death. J Exp Med. 2017 Aug 07;214(8):2217-2229
J:252669 Maelfait J, et al., Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis. EMBO J. 2017 Sep 1;36(17):2529-2543
J:258250 Kuriakose T, et al., IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection. J Immunol. 2018 Feb 15;200(4):1489-1495
J:279199 Ingram JP, et al., ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1. J Immunol. 2019 Sep 1;203(5):1348-1355
J:279203 Daniels BP, et al., The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons. Immunity. 2019 Jan 15;50(1):64-76.e4
J:289066 Upton JW, et al., DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe. 2012 Mar 15;11(3):290-7
J:289074 Guo H, et al., Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1. Cell Death Dis. 2018 Jul 26;9(8):816
J:289082 Zhang T, et al., Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis. Cell. 2020 Mar 19;180(6):1115-1129.e13
J:289096 Thapa RJ, et al., DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death. Cell Host Microbe. 2016 Nov 9;20(5):674-681
J:289444 Sridharan H, et al., Murine cytomegalovirus IE3-dependent transcription is required for DAI/ZBP1-mediated necroptosis. EMBO Rep. 2017 Aug;18(8):1429-1441
J:289445 Koehler H, et al., Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11506-11511
J:289451 Momota M, et al., ZBP1 governs the inflammasome-independent IL-1alpha and neutrophil inflammation that play a dual role in anti-influenza virus immunity. Int Immunol. 2020 Mar 7;32(3):203-212
J:289452 Jiao H, et al., Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature. 2020 Apr;580(7803):391-395
J:290292 Zheng M, et al., Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense. Cell. 2020 Apr 30;181(3):674-687.e13
J:290369 Kuriakose T, et al., ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways. Sci Immunol. 2016 Aug 5;1(2)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:294928 Devos M, et al., Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation. J Exp Med. 2020 Jul 6;217(7)
J:295921 Kesavardhana S, et al., The Zalpha2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development. J Biol Chem. 2020 Jun 12;295(24):8325-8330
J:300942 Banoth B, et al., ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis). J Biol Chem. 2020 Dec 25;295(52):18276-18283
J:300952 Muendlein HI, et al., ZBP1 promotes LPS-induced cell death and IL-1beta release via RHIM-mediated interactions with RIPK1. Nat Commun. 2021 Jan 4;12(1):86

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last database update
MGI 6.13
The Jackson Laboratory