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Gene Detail
HECT, UBA and WWE domain containing 1
Synonyms 5430439H10Rik, Arf-bp1, C430014N20Rik, Ib772, LOC382250, mKIAA0312, Mule, Ureb1
Feature Type protein coding gene
Genetic Map
Chromosome X
68.46 cM
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
ChrX:151800807-151935417 bp, + strand
From VEGA annotation of GRCm38

  134611 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:45994  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Huwe1

Human Homolog HUWE1, HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
NCBI Gene ID 10075
neXtProt AC  NX_Q7Z6Z7
Human Synonyms  ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MULE, UREB1, URE-B1
Human Chr (Location)  Xp11.22; chrX:53532096-53686729 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HUWE1
alleles, and
All mutations/alleles(95) : Gene trapped(87) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a conditional allele activated in neurons results in neonatal lethality, poorly developed dentate gyrus, small cerebellum, increased cortex density, and increased neuronal precursor cell proliferation.
Phenotype Images(39)
Huwe1 interacts with 458 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (29 annotations)
Process base-excision repair, cell differentiation, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Literature Summary: (5 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23
Assay TypeResults
RNA in situ 1
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(25) cDNA(25)
Microarray probesets(9)
Other database
VEGA Gene ModelOTTMUSG00000019367 (Evidence)
Ensembl Gene ModelENSMUSG00000025261 (Evidence)
Entrez Gene59026 (Evidence)
DFCITC1572089, TC1587942, TC1595506, TC1602142, TC1612047, TC1613889, TC1636492, TC1650514, TC1691740
DoTSDT.101197441, DT.101279015, DT.101314980, DT.101316447, DT.101345483, DT.101385838, DT.101738890, DT.111028947, DT.40173448, DT.487047, DT.495046, DT.91324204, DT.91590849, DT.94163933, DT.94293878, DT.97333644, DT.97346220, DT.99854761
NIA Mouse Gene IndexU020318
Consensus CDS ProjectCCDS41176.1
International Mouse Knockout Project StatusHuwe1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019367 VEGA Gene Model | MGI Sequence Detail 134611 C57BL/6J ±  kb
transcript OTTMUST00000046226 VEGA | MGI Sequence Detail 14579 Not Applicable 
polypeptide OTTMUSP00000020882 VEGA | MGI Sequence Detail 4378 Not Applicable 

For the selected sequences
All sequences(179) RefSeq(41) UniProt(12)
Polymorphisms SNPs within 2kb(380 from dbSNP Build 137)
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR025527 Domain of unknown function DUF4414
InterPro IPR010309 E3 ubiquitin ligase, domain of unknown function DUF908
InterPro IPR010314 E3 ubiquitin ligase, domain of unknown function DUF913
InterPro IPR000569 HECT
InterPro IPR009060 UBA-like
InterPro IPR000449 Ubiquitin-associated/translation elongation factor EF1B, N-terminal
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
InterPro IPR004170 WWE domain
Protein Ontology PR:000008845 E3 ubiquitin-protein ligase HUWE1
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:199183 Inoue S, et al., Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes Dev. 2013 May 15;27(10):1101-14
All references(55)
accession IDs
MGI:1918622, MGI:2147973, MGI:2148063, MGI:2443454, MGI:2686564

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory