Huwe1
Gene Detail

Symbol Name ID

Huwe1 HECT, UBA and WWE domain containing 1 MGI:1926884

Synonyms

5430439H10Rik, Arf-bp1, C430014N20Rik, Ib772, LOC382250, mKIAA0312, Mule, Ureb1

Feature Type

protein coding gene

Genetic Map

Chromosome X

68.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

ChrX:151800807-151935417 bp, + strand From VEGA annotation of GRCm38   134611 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:45994  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Huwe1

Human homologs

Human Homolog		HUWE1, HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
NCBI Gene ID		10075
neXtProt AC		NX_Q7Z6Z7
Human Synonyms		ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MULE, UREB1, URE-B1
Human Chr (Location)		Xp11.22; chrX:53559057-53713697 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HUWE1

Alleles and phenotypes

All alleles(94) : Targeted(7) Gene trapped(87)
 

Mice homozygous for a conditional allele activated in neurons results in neonatal lethality, poorly developed dentate gyrus, small cerebellum, increased cortex density, and increased neuronal precursor cell proliferation.

 
Phenotype Images(38)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	base-excision repair, cell differentiation, ...
Component	cytoplasm, nucleus
Function	DNA binding, ligase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23

Assay Type	Results
RNA in situ	1

cDNA source data(352)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(352) cDNA(352)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000019367 (Evidence)
Ensembl Gene Model	ENSMUSG00000025261 (Evidence)
Entrez Gene	59026 (Evidence)
UniGene	27372
DFCI	TC1572089, TC1587942, TC1595506, TC1602142, TC1612047, TC1613889, TC1636492, TC1650514, TC1691740
DoTS	DT.101197441, DT.101279015, DT.101314980, DT.101316447, DT.101345483, DT.101385838, DT.101738890, DT.111028947, DT.40173448, DT.487047, DT.495046, DT.91324204, DT.91590849, DT.94163933, DT.94293878, DT.97333644, DT.97346220, DT.99854761
NIA Mouse Gene Index	U020318
EC	6.3.2.-
Consensus CDS Project	CCDS41176.1
International Mouse Knockout Project Status	Huwe1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019367	VEGA Gene Model | MGI Sequence Detail	134611	C57BL/6J
transcript	OTTMUST00000046226	VEGA | MGI Sequence Detail	14579	Not Applicable
polypeptide	OTTMUSP00000020882	VEGA | MGI Sequence Detail	4378	Not Applicable

All sequences(141) RefSeq(3) UniProt(12)

Polymorphisms

SNPs(347 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR025527	Domain of unknown function DUF4414
InterPro	IPR010309	E3 ubiquitin ligase, domain of unknown function DUF908
InterPro	IPR010314	E3 ubiquitin ligase, domain of unknown function DUF913
InterPro	IPR000569	HECT
InterPro	IPR009060	UBA-like
InterPro	IPR000449	Ubiquitin-associated/translation elongation factor EF1B, N-terminal
InterPro	IPR015940	Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
InterPro	IPR004170	WWE domain
Protein Ontology	PR:000008845	E3 ubiquitin-protein ligase HUWE1

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:182446 Kon N, et al., Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice. J Biol Chem. 2012 Feb 10;287(7):5102-11
All references(52)

Other accession IDs

MGI:1918622, MGI:2147973, MGI:2148063, MGI:2443454, MGI:2686564