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Huwe1 Gene Detail
Summary
  • Symbol
    Huwe1
  • Name
    HECT, UBA and WWE domain containing 1
  • Synonyms
    5430439H10Rik, Arf-bp1, C430014N20Rik, Ib772, LOC382250, mKIAA0312, Mule, Ureb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926884
    NCBI Gene: 59026
  • Gene Overview
    MyGene.info: HUWE1
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:151800807-151935417 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 68.46 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    380 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926884
protein coding gene ChrX:151800807-151935417 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036179
protein coding gene ChrX:149553263-149688073 (+)
A/J MGP_AJ_G0036155
protein coding gene ChrX:148744014-148880853 (+)
AKR/J MGP_AKRJ_G0036081
protein coding gene ChrX:153552852-153692407 (+)
BALB/cJ MGP_BALBcJ_G0036146
protein coding gene ChrX:146931107-147072970 (+)
C3H/HeJ MGP_C3HHeJ_G0035854
protein coding gene ChrX:149764355-149900020 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036671
protein coding gene ChrX:153793944-153931339 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033495
protein coding gene ChrX:140439842-140577828 (+)
CAST/EiJ MGP_CASTEiJ_G0035145
protein coding gene ChrX:129167633-129309811 (+)
CBA/J MGP_CBAJ_G0035831
protein coding gene ChrX:158342649-158479585 (+)
DBA/2J MGP_DBA2J_G0035989
protein coding gene ChrX:147822066-147957567 (+)
FVB/NJ MGP_FVBNJ_G0035923
protein coding gene ChrX:146942843-147078814 (+)
LP/J MGP_LPJ_G0036080
protein coding gene ChrX:150637075-150774433 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035959
protein coding gene ChrX:166483459-166641896 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036706
protein coding gene ChrX:149065668-149204731 (+)
PWK/PhJ MGP_PWKPhJ_G0034839
protein coding gene ChrX:126129558-126268770 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034665
protein coding gene ChrX:129640768-129782009 (+)
WSB/EiJ MGP_WSBEiJ_G0035280
protein coding gene ChrX:147127777-147267007 (+)



Homology
more
  • Human Ortholog
    HUWE1, HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HUWE1, HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MULE, UREB1, URE-B1
  • Links
    NCBI Gene ID: 10075
    neXtProt AC: NX_Q7Z6Z7
    UniProt: Q7Z6Z7

  • Chr Location
    Xp11.22; chrX:53532096-53686729 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human HUWE1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 7 alleles in 8 genetic backgrounds
    9 phenotypes from multigenic genotypes
    39 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in neurons results in neonatal lethality, poorly developed dentate gyrus, small cerebellum, increased cortex density, and increased neuronal precursor cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 59026 NCBI Gene Model | MGI Sequence Detail 134611 C57BL/6J ±  kb
    transcript NM_021523 RefSeq | MGI Sequence Detail 14637 C57BL/6  
    polypeptide Q7TMY8 UniProt | EBI | MGI Sequence Detail 4377 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1918622, MGI:2147973, MGI:2148063, MGI:2443454, MGI:2686564
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 23
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:249977 Fok KL, et al., Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response. Endocrinology. 2017 Nov 01;158(11):4000-4016

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory