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Huwe1
Gene Detail
Symbol

Name
ID
Huwe1
HECT, UBA and WWE domain containing 1
MGI:1926884
Synonyms
5430439H10Rik, Arf-bp1, C430014N20Rik, Ib772, LOC382250, mKIAA0312, Mule, Ureb1
Feature Type
protein coding gene
Genetic Map
Chromosome X
68.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:151800807-151935417 bp, + strand
From VEGA annotation of GRCm38

  134611 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45994  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HUWE1
Gene Tree: Huwe1

Human
homologs
HUWE1, HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10075
neXtProt AC: NX_Q7Z6Z7

Human Synonyms: ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MULE, UREB1, URE-B1

Human Chr (Location): Xp11.22; chrX:53532096-53686729 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HUWE1

Mutations,
alleles, and
phenotypes
All mutations/alleles(95) : Gene trapped(87) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a conditional allele activated in neurons results in neonatal lethality, poorly developed dentate gyrus, small cerebellum, increased cortex density, and increased neuronal precursor cell proliferation.
 
Phenotype Images(39)
Interactions
Huwe1 interacts with 457 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase huwe1    NEW 
Molecular
reagents
All nucleic(25) cDNA(25)
Microarray probesets(9)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019367 VEGA Gene Model | MGI Sequence Detail 134611 C57BL/6J ±  kb
transcript OTTMUST00000046226 VEGA | MGI Sequence Detail 14579 Not Applicable 
polypeptide OTTMUSP00000020882 VEGA | MGI Sequence Detail 4378 Not Applicable 

For the selected sequences
All sequences(186) RefSeq(47) UniProt(13)
Polymorphisms
SNPs within 2kb(380 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR025527 Domain of unknown function DUF4414
InterPro IPR010309 E3 ubiquitin ligase, domain of unknown function DUF908
InterPro IPR010314 E3 ubiquitin ligase, domain of unknown function DUF913
InterPro IPR000569 HECT domain
InterPro IPR009060 UBA-like
InterPro IPR015940 Ubiquitin-associated domain
InterPro IPR004170 WWE domain
Protein Ontology PR:000008845 E3 ubiquitin-protein ligase HUWE1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:216999 Wang L, et al., Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions. Diabetologia. 2014 Sep;57(9):1889-98
All references(55)
Other
accession IDs
MGI:1918622, MGI:2147973, MGI:2148063, MGI:2443454, MGI:2686564

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory