About   Help   FAQ
Kcnq1ot1 Gene Detail
Summary
  • Symbol
    Kcnq1ot1
  • Name
    KCNQ1 overlapping transcript 1
  • Synonyms
    Kvlqt1-as, Lit1, Tssc8
  • Feature Type
    antisense lncRNA gene
  • IDs
    MGI:1926855
    NCBI Gene: 63830
  • Gene Overview
    MyGene.info: KCNQ1OT1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:143213111-143296547 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.15 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    476 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926855
antisense lncRNA gene Chr7:143203458-143296549 (-)
129S1/SvImJ MGP_129S1SvImJ_G0004525
antisense lncRNA gene Chr7:148501128-148581252 (-)
A/J MGP_AJ_G0004505
antisense lncRNA gene Chr7:144194988-144279146 (-)
AKR/J MGP_AKRJ_G0004488
antisense lncRNA gene Chr7:148245318-148329911 (-)
BALB/cJ MGP_BALBcJ_G0004490
antisense lncRNA gene Chr7:143971895-144061794 (-)
C3H/HeJ MGP_C3HHeJ_G0004439
antisense lncRNA gene Chr7:148007446-148093893 (-)
C57BL/6NJ MGP_C57BL6NJ_G0004640
antisense lncRNA gene Chr7:153865226-153958929 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0004094
antisense lncRNA gene Chr7:145409242-145489715 (-)
CAST/EiJ MGP_CASTEiJ_G0004399
antisense lncRNA gene Chr7:140311752-140398676 (-)
CBA/J MGP_CBAJ_G0004434
antisense lncRNA gene Chr7:159129029-159213362 (-)
DBA/2J MGP_DBA2J_G0004448
antisense lncRNA gene Chr7:142168455-142251232 (-)
FVB/NJ MGP_FVBNJ_G0004465
antisense lncRNA gene Chr7:142093325-142178121 (-)
LP/J MGP_LPJ_G0004529
antisense lncRNA gene Chr7:150025760-150117515 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0004454
antisense lncRNA gene Chr7:159712398-159811741 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0004639
antisense lncRNA gene Chr7:147210806-147293388 (-)
PWK/PhJ MGP_PWKPhJ_G0004352
antisense lncRNA gene Chr7:135474127-135562977 (-)
SPRET/EiJ MGP_SPRETEiJ_G0004293
antisense lncRNA gene Chr7:134015576-134105281 (-)
WSB/EiJ MGP_WSBEiJ_G0004438
antisense lncRNA gene Chr7:148215047-148296153 (-)



Homology
more
  • Human Ortholog
    KCNQ1OT1, KCNQ1 opposite strand/antisense transcript 1
  • Human Ortholog
    KCNQ1OT1, KCNQ1 opposite strand/antisense transcript 1
    Orthology source: HGNC
  • Synonyms
    KCNQ10T1, KCNQ1-AS2, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012
  • Links
    NCBI Gene ID: 10984

  • Chr Location
    11p15.5; chr11:2608328-2699998 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KCNQ1OT1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 9 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice heterozygous for any of several independently generated targeted alleles exhibit abnormal imprinting and may display a growth deficiency.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 63830 NCBI Gene Model | MGI Sequence Detail 83437 C57BL/6J ±  kb
    transcript NR_001461 RefSeq | MGI Sequence Detail 83437 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 25
      Primer pair 8

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1930304
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 25
      Gene Ontology 3
      Phenotypes 18
    • Earliest
      J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
    • Latest
      J:275000 Sharma A, et al., miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta. Dev Biol. 2019 May 1;449(1):21-34

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/11/2019
    MGI 6.14
    The Jackson Laboratory