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Kcnq1ot1 Gene Detail
Summary
  • Symbol
    Kcnq1ot1
  • Name
    KCNQ1 overlapping transcript 1
  • Synonyms
    Kvlqt1-as, Lit1, Tssc8
  • Feature Type
    antisense lncRNA gene
  • IDs
    MGI:1926855
    NCBI Gene: 63830
  • Gene Overview
    MyGene.info: KCNQ1OT1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:143212155-143296549 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      84395 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.15 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    KCNQ1OT1, KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)
  • Human Ortholog
    KCNQ1OT1, KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)
    Orthology source: HGNC
  • Synonyms
    KCNQ10T1, KCNQ1-AS2, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012
  • Links
    NCBI Gene ID: 10984

  • Chr Location
    11p15.5; chr11:2608328-2699998 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KCNQ1OT1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 9 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for any of several independently generated targeted alleles exhibit abnormal imprinting and may display a growth deficiency.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000046380 VEGA Gene Model | MGI Sequence Detail 84395 C57BL/6J ±  kb
    transcript OTTMUST00000120849 VEGA | MGI Sequence Detail 84395 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      487 from dbSNP Build 142
    • PCR
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 22
      Primer pair 8

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1930304
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 24
      Gene Ontology 3
      Phenotypes 17
    • Earliest
      J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
    • Latest
      J:251884 Lee CC, et al., The Role of N-alpha-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting. Mol Cell. 2017 Oct 5;68(1):89-103.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory