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Gucy1a3
Gene Detail
 Symbol
Name
ID
Gucy1a3
guanylate cyclase 1, soluble, alpha 3
MGI:1926562
Synonyms 1200016O07Rik, alpha 1 sGC, sGC-alpha1
Feature Type protein coding gene
Genetic Map
Chromosome 3
35.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:82092428-82145877 bp, - strand
From Ensembl annotation of GRCm38

  53450 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37360  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: soluble guanylate cyclase
Gene Tree: Gucy1a3

Human
homologs
Human Homolog GUCY1A3, guanylate cyclase 1, soluble, alpha 3
NCBI Gene ID 2982
neXtProt AC  NX_Q02108
Human Synonyms  GC-SA3, GUC1A3, GUCA3, GUCSA3, GUCY1A1, MYMY6
Human Chr (Location)  4q31.1-q31.2; chr4:155666710-155737062 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GUCY1A3
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display mild elevation of systolic blood pressure, and abnormal blood vessel and platelet responses to NO.
 
Human Diseases Modeled Using Mouse Gucy1a3 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Gucy1a3 interacts with 343 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cGMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component cytoplasm, guanylate cyclase complex, soluble, ...
Function GTP binding, guanylate cyclase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (510)    Tissues (202)    Images (62)
Theiler Stages: 20, 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 508
RT-PCR 2
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(11) Primer pair(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000033910 (Evidence)
Entrez Gene60596 (Evidence)
DFCITC1576525
DoTSDT.101349795, DT.60104324
NIA Mouse Gene IndexU024189
EC4.6.1.2
Consensus CDS ProjectCCDS17429.1
International Mouse Knockout Project StatusGucy1a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033910 Ensembl Gene Model | MGI Sequence Detail 53450 C57BL/6J ±  kb
transcript ENSMUST00000048976 Ensembl | MGI Sequence Detail 4653 Not Applicable 
polypeptide ENSMUSP00000048918 Ensembl | MGI Sequence Detail 691 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(507 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro IPR011645 Haem NO binding associated
InterPro IPR011644 Heme-NO binding
InterPro IPR024096 NO signalling/Golgi transport ligand-binding domain
Protein Ontology PR:000008349 guanylate cyclase soluble subunit alpha-3
References (Earliest) J:64709 Sharina IG, et al., Genomic organization of alpha 1 and beta 1 subunits of the mammalian soluble guanylyl cyclase genes. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10878-83
(Latest) J:210215 Schirwis E, et al., The beneficial effect of myostatin deficiency on maximal muscle force and power is attenuated with age. Exp Gerontol. 2013 Feb;48(2):183-90
All references(57)
Disease annotation references (1)
Other
accession IDs
MGI:1921380

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory