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Gucy1a1 Gene Detail
Summary
  • Symbol
    Gucy1a1
  • Name
    guanylate cyclase 1, soluble, alpha 1
  • Synonyms
    1200016O07Rik, alpha 1 sGC, Gucy1a3, sGC-alpha1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926562
    NCBI Gene: 60596
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:81999734-82053096 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 35.97 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1759 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926562
 protein coding gene Chr3:81999734-82053253 (-)
129S1/SvImJ ENSMUSG00200018828
 protein coding gene Chr3:78852257-78905634 (-)
A/J ENSMUSG00195011363
 protein coding gene Chr3:78860160-78913547 (-)
AKR/J ENSMUSG00220001264
 protein coding gene Chr3:78816307-78869659 (-)
BALB/cJ ENSMUSG00180001885
 protein coding gene Chr3:78989181-79042515 (-)
C3H/HeJ ENSMUSG00175007055
 protein coding gene Chr3:78786811-78840191 (-)
C57BL/6NJ ENSMUSG00215001977
 protein coding gene Chr3:79239710-79293070 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025098
 protein coding gene Chr3:74948052-75002016 (-)
CAST/EiJ ENSTCUG00005001551
 protein coding gene Chr3:78327488-78380995 (-)
CBA/J ENSMUSG00210025244
 protein coding gene Chr3:78917341-78970729 (-)
DBA/2J ENSMUSG00185012677
 protein coding gene Chr3:79073871-79127220 (-)
FVB/NJ ENSMUSG00205005921
 protein coding gene Chr3:77844660-77898010 (-)
JF1/MsJ ENSUMUG00000001188
 protein coding gene Chr3:78595373-78648850 (-)
LP/J ENSMUSG00230008866
 protein coding gene Chr3:81060860-81114232 (-)
NOD/ShiLtJ ENSMUSG00190002711
 protein coding gene Chr3:79312911-79366273 (-)
NZO/HlLtJ ENSMUSG00225006245
 protein coding gene Chr3:83792361-83845715 (-)
PWK/PhJ ENSLUMG00010006191
 protein coding gene Chr3:78664596-78718089 (-)
SPRET/EiJ ENSMSPG00010016340
 protein coding gene Chr3:79470803-79522295 (-)
WSB/EiJ ENSIUOG00005002829
 protein coding gene Chr3:79290990-79344398 (-)



Homology
more
  • Human Ortholog
    GUCY1A1, guanylate cyclase 1 soluble subunit alpha 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GUCY1A1, guanylate cyclase 1 soluble subunit alpha 1
  • Synonyms
    GC-SA3, GC-S-alpha-1, GCS-alpha-3, GUC1A3, GUCA3, GUCSA3, GUCY1A3, MYMY6
  • Links
    NCBI Gene ID: 2982
    UniProt: Q02108

  • Chr Location
    4q32.1; chr4:155666707-155737059 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gucy1a1 mouse models; 1 with human GUCY1A1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 4 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display mild elevation of systolic blood pressure, and abnormal blood vessel and platelet responses to NO.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1170
  • Tissues
    230
  • cDNA Data
    12
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033910 Ensembl Gene Model | MGI Sequence Detail 53363 C57BL/6J ±  kb
    transcript ENSMUST00000048976 Ensembl | MGI Sequence Detail 4554 Not Applicable  
    polypeptide ENSMUSP00000048918 Ensembl | MGI Sequence Detail 691 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008349 guanylate cyclase soluble subunit alpha-1
      (term hierarchy)
    • EC
      4.6.1.2
    • InterPro Domains
      IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
      IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
      IPR011645 Haem NO binding associated
      IPR042463 Haem NO binding associated domain superfamily
      IPR038158 H-NOX domain superfamily
      IPR024096 NO signalling/Golgi transport ligand-binding domain superfamily
      IPR029787 Nucleotide cyclase
    • GlyGen
      Q9ERL9 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 15
      Primer pair 2
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1921380, MGI:5927631
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 12
      Diseases 2
      Gene Ontology 10
      Phenotypes 40
    • Earliest
      J:64709 Sharina IG, et al., Genomic organization of alpha 1 and beta 1 subunits of the mammalian soluble guanylyl cyclase genes. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10878-83
    • Latest
      J:367455 Mohanty I, et al., Proteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies. Commun Biol. 2025 May 27;8(1):817
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory