Gucy1a1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gucy1a1
guanylate cyclase 1, soluble, alpha 1
MGI:1926562

14 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gucy1a1^tm1.1Brou/Gucy1a1^tm1.1Brou involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	abnormal aqueous humor	J:199535
	abnormal eye physiology	J:199535
	abnormal optic nerve morphology	J:199535
	abnormal retina nerve fiber layer morphology	J:199535
	decreased retina ganglion cell number	J:199535
	ocular hypertension	J:199535
Gucy1a1^tm1.1Brou/Gucy1a1^tm1.1Brou involves: 129S1/Sv * 129X1/SvJ	abnormal heart right ventricle pressure	J:139850
	abnormal lung vasculature morphology	J:139850
	heart right ventricle hypertrophy	J:139850
	increased systemic arterial blood pressure	J:139850
Gucy1a1^tm1.1Brou/Gucy1a1^tm1.1Brou involves: 129S1/Sv * 129X1/SvJ * C57BL/6	increased susceptibility to induced morbidity/mortality	J:113106
Gucy1a1^tm1.1Dko/Gucy1a1^tm1.1Dko involves: C57BL/6	abnormal platelet aggregation	J:110362
	abnormal vasodilation	J:110362
	increased systemic arterial systolic blood pressure	J:110362

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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