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Nectin1 Gene Detail
Summary
  • Symbol
    Nectin1
  • Name
    nectin cell adhesion molecule 1
  • Synonyms
    Cd111, HIgR, HveC, nectin-1, PRR, PRR1, Pvrl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926483
    NCBI Gene: 58235
  • Gene Overview
    MyGene.info: NECTIN1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:43744576-43807461 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.42 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    341 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926483
protein coding gene Chr9:43743984-43807461 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034686
protein coding gene Chr9:42168714-42232306 (+)
A/J MGP_AJ_G0034666
protein coding gene Chr9:41023567-41086267 (+)
AKR/J MGP_AKRJ_G0034592
protein coding gene Chr9:41841052-41903748 (+)
BALB/cJ MGP_BALBcJ_G0034657
protein coding gene Chr9:40754576-40817676 (+)
C3H/HeJ MGP_C3HHeJ_G0034368
protein coding gene Chr9:42321893-42388660 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035180
protein coding gene Chr9:43439226-43507024 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032093
protein coding gene Chr9:40623012-40685420 (+)
CAST/EiJ MGP_CASTEiJ_G0033691
protein coding gene Chr9:42142943-42207472 (+)
CBA/J MGP_CBAJ_G0034341
protein coding gene Chr9:44983902-45054620 (+)
DBA/2J MGP_DBA2J_G0034500
protein coding gene Chr9:40934910-40998378 (+)
FVB/NJ MGP_FVBNJ_G0034440
protein coding gene Chr9:40179778-40243889 (+)
LP/J MGP_LPJ_G0034581
protein coding gene Chr9:42471182-42536810 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034484
protein coding gene Chr9:46895431-46961949 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035199
protein coding gene Chr9:41747607-41813087 (+)
PWK/PhJ MGP_PWKPhJ_G0033396
protein coding gene Chr9:40792024-40855162 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033232
protein coding gene Chr9:42035479-42098532 (+)
WSB/EiJ MGP_WSBEiJ_G0033804
protein coding gene Chr9:41795390-41862855 (+)



Homology
more
  • Human Ortholog
    NECTIN1, nectin cell adhesion molecule 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NECTIN1, nectin cell adhesion molecule 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD111, CLPED1, ED4, HIgR, HV1S, HVEC, nectin-1, OFC7, PRR, PRR1, PVRL1, PVRR, PVRR1, SK-12
  • Links
    NCBI Gene ID: 5818
    neXtProt AC: NX_Q15223
    UniProt: Q15223

  • Chr Location
    11q23.3; chr11:119638098-119728725 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human NECTIN1 associations

Human Disease Mouse Models
      
IDs
View 3 "NOT" models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit eye abnormalities including microphthalmia, absent vitreous body, abnormal ciliary body, retinal layers, and lenses, and open eyelids at birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58235 NCBI Gene Model | MGI Sequence Detail 62886 C57BL/6J ±  kb
    transcript NM_021424 RefSeq | MGI Sequence Detail 5701 C57BL/6  
    polypeptide Q9JKF6 UniProt | EBI | MGI Sequence Detail 515 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 2
      cDNA 52
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2143125, MGI:2143319
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 31
      Diseases 1
      Gene Ontology 15
      Phenotypes 20
    • Earliest
      J:61531 Satoh-Horikawa K, et al., Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. J Biol Chem. 2000 Apr 7;275(14):10291-9
    • Latest
      J:244304 Richardson R, et al., p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate. PLoS Genet. 2017 Jun;13(6):e1006828

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory