Pvrl1
Gene Detail

Symbol Name ID

Pvrl1 poliovirus receptor-related 1 MGI:1926483

Synonyms

Cd111, HIgR, HveC, nectin-1, PRR, PRR1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

24.42 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:43744576-43807454 bp, + strand From Ensembl annotation of GRCm38   62879 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2138  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: poliovirus receptor-related protein
Gene Tree: Pvrl1

Human homologs

Human Homolog		PVRL1, poliovirus receptor-related 1 (herpesvirus entry mediator C)
NCBI Gene ID		5818
neXtProt AC		NX_Q15223
Human Synonyms		CD111, CLPED1, ED4, HIgR, HVEC, nectin-1, OFC7, PRR, PRR1, PVRR, PVRR1, SK-12
Human Chr (Location)		11q23.3; chr11:119508808-119599435 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PVRL1

Alleles and phenotypes

All alleles(9) : Targeted(4) Gene trapped(5)
 

Homozygous null mice exhibit eye abnormalities including microphthalmia, absent vitreous body, abnormal ciliary body, retinal layers, and lenses, and open eyelids at birth.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	axon guidance, camera-type eye morphogenesis, ...
Component	axon, catenin complex, ...
Function	carbohydrate binding, cell adhesion molecule binding, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (8)    Tissues (4)   
Theiler Stages: 23

Assay Type	Results
RNA in situ	8

cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(53) Genomic(1) cDNA(51) Primer pair(1)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000032012 (Evidence)
Entrez Gene	58235 (Evidence)
UniGene	335096
DFCI	TC1586642, TC1603911, TC1634349
DoTS	DT.489052
NIA Mouse Gene Index	U010371
Consensus CDS Project	CCDS23092.1
International Mouse Knockout Project Status	Pvrl1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032012	Ensembl Gene Model | MGI Sequence Detail	62879	C57BL/6J
transcript	ENSMUST00000034510	Ensembl | MGI Sequence Detail	5054	Not Applicable
polypeptide	ENSMUSP00000034510	Ensembl | MGI Sequence Detail	515	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(247 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013162	CD80-like, immunoglobulin C2-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR013106	Immunoglobulin V-set
Protein Ontology	PR:000002068	poliovirus receptor-related protein 1

References

(Earliest) J:61950 Menotti L, et al., The murine homolog of human Nectin1delta serves as a species nonspecific mediator for entry of human and animal alpha herpesviruses in a pathway independent of a detectable binding to gD. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4867-72
(Latest) J:193131 Karaba AH, et al., Herpesvirus entry mediator is a serotype specific determinant of pathogenesis in ocular herpes. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20649-54
All references(58)

Other accession IDs

MGI:2143125, MGI:2143319