About   Help   FAQ
Pvrl1
Gene Detail
 Symbol
Name
ID
Pvrl1
poliovirus receptor-related 1
MGI:1926483
Synonyms Cd111, HIgR, HveC, nectin-1, PRR, PRR1
Feature Type protein coding gene
Genetic Map
Chromosome 9
24.42 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:43744576-43807454 bp, + strand
From Ensembl annotation of GRCm38

  62879 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2138  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: poliovirus receptor-related protein
Gene Tree: Pvrl1

Human
homologs
Human Homolog PVRL1, poliovirus receptor-related 1 (herpesvirus entry mediator C)
NCBI Gene ID 5818
neXtProt AC  NX_Q15223
Human Synonyms  CD111, CLPED1, ED4, HIgR, HVEC, nectin-1, OFC7, PRR, PRR1, PVRR, PVRR1, SK-12
Human Chr (Location)  11q23.3; chr11:119638098-119728725 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PVRL1
Alleles
and
phenotypes
All alleles(9) : Gene trapped(5) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit eye abnormalities including microphthalmia, absent vitreous body, abnormal ciliary body, retinal layers, and lenses, and open eyelids at birth.
 
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process axon guidance, camera-type eye morphogenesis, ...
Component axon, catenin complex, ...
Function carbohydrate binding, cell adhesion molecule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (14)    Tissues (9)    Images (13)
Theiler Stages: 21, 23, 25, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 13
cDNA source data(52)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(54) Genomic(1) cDNA(52) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000032012 (Evidence)
Entrez Gene58235 (Evidence)
UniGene335096
DFCITC1586642, TC1603911, TC1634349
DoTSDT.489052
NIA Mouse Gene IndexU010371
PDB2L7J
Consensus CDS ProjectCCDS23092.1
International Mouse Knockout Project StatusPvrl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032012 Ensembl Gene Model | MGI Sequence Detail 62879 C57BL/6J ±  kb
transcript ENSMUST00000034510 Ensembl | MGI Sequence Detail 5054 Not Applicable 
polypeptide ENSMUSP00000034510 Ensembl | MGI Sequence Detail 515 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(341 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000002068 poliovirus receptor-related protein 1
References (Earliest) J:61531 Satoh-Horikawa K, et al., Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. J Biol Chem. 2000 Apr 7;275(14):10291-9
(Latest) J:206576 Fukuda T, et al., Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities. Development. 2014 Jan;141(2):399-409
All references(64)
Other
accession IDs
MGI:2143125, MGI:2143319

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory