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Nectin1 Gene Detail
Summary
  • Symbol
    Nectin1
  • Name
    nectin cell adhesion molecule 1
  • Synonyms
    Cd111, HIgR, HveC, nectin-1, PRR, PRR1, Pvrl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926483
    NCBI Gene: 58235
  • Gene Overview
    MyGene.info: NECTIN1
Location & Maps
more
  • Sequence Map
    Chr9:43744576-43807454 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62879 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.42 cM, cytoband B
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NECTIN1, nectin cell adhesion molecule 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NECTIN1, nectin cell adhesion molecule 1
    Orthology source: HomoloGene
  • Synonyms
    CD111, CLPED1, ED4, HIgR, HV1S, HVEC, nectin-1, OFC7, PRR, PRR1, PVRL1, PVRR, PVRR1, SK-12
  • Links
    NCBI Gene ID: 5818
    neXtProt AC: NX_Q15223

  • Chr Location
    11q23.3; chr11:119638098-119728725 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Nectin1 mouse models; 1 with human NECTIN1 associations

Human Disease Mouse Models
       Cleft Lip/Palate-Ectodermal Dysplasia Syndrome; CLPED1   OMIM: 225060 View 3 "NOT" models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit eye abnormalities including microphthalmia, absent vitreous body, abnormal ciliary body, retinal layers, and lenses, and open eyelids at birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032012 Ensembl Gene Model | MGI Sequence Detail 62879 C57BL/6J ±  kb
transcript ENSMUST00000034510 Ensembl | MGI Sequence Detail 5054 Not Applicable  
polypeptide ENSMUSP00000034510 Ensembl | MGI Sequence Detail 515 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    341 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 54
    Genomic 1
    cDNA 52
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:2143125, MGI:2143319
References
more
  • Summaries
    All 69
    Developmental Gene Expression 27
    Diseases 1
    Gene Ontology 13
    Phenotypes 17
  • Earliest
    J:61531 Satoh-Horikawa K, et al., Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. J Biol Chem. 2000 Apr 7;275(14):10291-9
  • Latest
    J:231229 Kitayama M, et al., A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development. J Biol Chem. 2016 Mar 11;291(11):5817-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory