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Nectin1tm1Ytk
Targeted Allele Detail
Summary
Symbol: Nectin1tm1Ytk
Name: nectin cell adhesion molecule 1; targeted mutation 1, Yoshimi Takai
MGI ID: MGI:3605480
Synonyms: nectin 1-
Gene: Nectin1  Location: Chr9:43655251-43718758 bp, + strand  Genetic Position: Chr9, 24.42 cM, cytoband B
Alliance: Nectin1tm1Ytk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101707
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA construct was designed to replace sequence in exon 2 encoding amino acids 26-143 with a neomycin resistance gene. Absence of protein was confirmed by Western blot. (J:101707)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 16 assay results
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nectin1 Mutation:  22 strains or lines available
References
Original:  J:101707 Inagaki M, et al., Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development. Development. 2005 Apr;132(7):1525-37
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory