Phenotypes associated with this allele
Allelic
Composition |
Nectin1tm1Ytk/Nectin1tm1Ytk
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Genetic
Background |
either: (involves: 129X1/SvJ * C57BL * DBA) or (involves: 129X1/SvJ * BALB/cA * C57BL * DBA) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nectin1tm1Ytk mutation
(1 available);
any
Nectin1 mutation
(22 available)
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vision/eye
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• ciliary epithelia adhere to the lens
• separation of the apex-apex contact between the pigment and non-pigment cell layers of the ciliary epithelia at E16.5, however no impairment of the apicolateral junctions between the pigment epithelia or the apicolateral junctions between the non-pigment epithelia
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• ciliary processes are absent
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• lenses are somewhat deformed
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• eyelids are not fused at E16.5 as in wild-type
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• about 30% of pups are born with one or both eyes open
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• retinal layers are undulating
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• vitreous body is absent
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nectin1tm1Ytk mutation
(1 available);
any
Nectin1 mutation
(22 available)
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craniofacial
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• lower incisors are chalky white
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• lower incisors display abnormal wear at the apex
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• occlusal surfaces show massive wear resulting in the absence of cusps on the 2nd and 3rd molar
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• smaller lower molars in keeping with smaller body size
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skeleton
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• lower incisors are chalky white
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• lower incisors display abnormal wear at the apex
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• occlusal surfaces show massive wear resulting in the absence of cusps on the 2nd and 3rd molar
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• smaller lower molars in keeping with smaller body size
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growth/size/body
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• lower incisors are chalky white
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• lower incisors display abnormal wear at the apex
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• occlusal surfaces show massive wear resulting in the absence of cusps on the 2nd and 3rd molar
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• smaller lower molars in keeping with smaller body size
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nectin1tm1Ytk mutation
(1 available);
any
Nectin1 mutation
(22 available)
Nectin3tm1Ytk mutation
(0 available);
any
Nectin3 mutation
(44 available)
|
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mortality/aging
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• only 1 double mutant was found after E17
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behavior/neurological
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• become progressively weaker with age starting at P5
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homeostasis/metabolism
integument
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nectin1tm1Ytk mutation
(1 available);
any
Nectin1 mutation
(22 available)
Nectin3tm1Ytk mutation
(0 available);
any
Nectin3 mutation
(44 available)
|
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craniofacial
|
N |
• unlike human Cleft Lip/Palate-Ectodermal Dysplasia Syndrome 1 (CLPED1) patients, no mice with cleft palate are detected and all teeth are present
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• at P10 the crown shape of the upper molars is conical and a defect in enamel formation is seen
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• at P10 the crown shape of the upper molars is conical
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• at P10 a defect in enamel formation is seen in the upper molars
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• at P10 the arrangement of the ameloblasts is abnormal and the ameloblast cell layer is detached from the stratum intermedium cell layer
• at P10 polarization of ameloblasts is impaired and ameloblasts are partially detached from each other
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• at P10 the stellate reticulum compartment of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 cells in the stratum reticulum compartment have abnormal shapes and lack the normal cell junction structures
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• at P10 the stratum intermedium cell layer of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 expression analysis indicates abnormalities in the adherens junctions and desmosomes in the stratum intermedium cell layer
• at P10 blood vessels are absent from the stratum intermedium
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skeleton
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• at P10 the crown shape of the upper molars is conical and a defect in enamel formation is seen
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• at P10 the crown shape of the upper molars is conical
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• at P10 a defect in enamel formation is seen in the upper molars
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• at P10 the arrangement of the ameloblasts is abnormal and the ameloblast cell layer is detached from the stratum intermedium cell layer
• at P10 polarization of ameloblasts is impaired and ameloblasts are partially detached from each other
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• at P10 the stellate reticulum compartment of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 cells in the stratum reticulum compartment have abnormal shapes and lack the normal cell junction structures
|
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• at P10 the stratum intermedium cell layer of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 expression analysis indicates abnormalities in the adherens junctions and desmosomes in the stratum intermedium cell layer
• at P10 blood vessels are absent from the stratum intermedium
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growth/size/body
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• at P10 the crown shape of the upper molars is conical and a defect in enamel formation is seen
|
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• at P10 the crown shape of the upper molars is conical
|
|
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• at P10 a defect in enamel formation is seen in the upper molars
|
|
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• at P10 the arrangement of the ameloblasts is abnormal and the ameloblast cell layer is detached from the stratum intermedium cell layer
• at P10 polarization of ameloblasts is impaired and ameloblasts are partially detached from each other
|
|
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• at P10 the stellate reticulum compartment of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 cells in the stratum reticulum compartment have abnormal shapes and lack the normal cell junction structures
|
|
|
• at P10 the stratum intermedium cell layer of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 expression analysis indicates abnormalities in the adherens junctions and desmosomes in the stratum intermedium cell layer
• at P10 blood vessels are absent from the stratum intermedium
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nectin1tm1Ytk mutation
(1 available);
any
Nectin1 mutation
(22 available)
Nectin3tm1Ytk mutation
(0 available);
any
Nectin3 mutation
(44 available)
|
|
|
craniofacial
|
N |
• unlike human Cleft Lip/Palate-Ectodermal Dysplasia Syndrome 1 (CLPED1) patients, no mice with cleft palate are detected and all teeth are present
|
|
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• at P10 the crown shape of the upper molars is conical and a defect in enamel formation is seen
|
|
|
• at P10 the crown shape of the upper molars is conical
|
|
|
• at P10 a defect in enamel formation is seen in the upper molars
|
|
|
• at P10 the arrangement of the ameloblasts is abnormal
• at P10 minor ruptures between the ameloblast and stratum intermedium cell layers are detected
• at P10 polarization of ameloblasts is impaired
|
|
|
• at P10 the stellate reticulum compartment of the epithelial enamel organ of the upper molars is hypoplastic
|
|
|
• at P10 the stratum intermedium cell layer of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 expression analysis indicates abnormalities in the adherens junctions and desmosomes in the stratum intermedium cell layer
• at P10 blood vessels are absent from the stratum intermedium
|
skeleton
|
|
• at P10 the crown shape of the upper molars is conical and a defect in enamel formation is seen
|
|
|
• at P10 the crown shape of the upper molars is conical
|
|
|
• at P10 a defect in enamel formation is seen in the upper molars
|
|
|
• at P10 the arrangement of the ameloblasts is abnormal
• at P10 minor ruptures between the ameloblast and stratum intermedium cell layers are detected
• at P10 polarization of ameloblasts is impaired
|
|
|
• at P10 the stellate reticulum compartment of the epithelial enamel organ of the upper molars is hypoplastic
|
|
|
• at P10 the stratum intermedium cell layer of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 expression analysis indicates abnormalities in the adherens junctions and desmosomes in the stratum intermedium cell layer
• at P10 blood vessels are absent from the stratum intermedium
|
growth/size/body
|
|
• at P10 the crown shape of the upper molars is conical and a defect in enamel formation is seen
|
|
|
• at P10 the crown shape of the upper molars is conical
|
|
|
• at P10 a defect in enamel formation is seen in the upper molars
|
|
|
• at P10 the arrangement of the ameloblasts is abnormal
• at P10 minor ruptures between the ameloblast and stratum intermedium cell layers are detected
• at P10 polarization of ameloblasts is impaired
|
|
|
• at P10 the stellate reticulum compartment of the epithelial enamel organ of the upper molars is hypoplastic
|
|
|
• at P10 the stratum intermedium cell layer of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 expression analysis indicates abnormalities in the adherens junctions and desmosomes in the stratum intermedium cell layer
• at P10 blood vessels are absent from the stratum intermedium
|
Analysis Tools