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Rnf170 Gene Detail
Summary
  • Symbol
    Rnf170
  • Name
    ring finger protein 170
  • Synonyms
    6720407G21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924983
    NCBI Gene: 77733
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:26119365-26143874 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 14.38 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924983
protein coding gene Chr8:26119365-26151790 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033496
protein coding gene Chr8:24214610-24239550 (+)
A/J MGP_AJ_G0033476
protein coding gene Chr8:23326297-23351116 (+)
AKR/J MGP_AKRJ_G0033401
protein coding gene Chr8:24095382-24122243 (+)
BALB/cJ MGP_BALBcJ_G0033472
protein coding gene Chr8:23475731-23500449 (+)
C3H/HeJ MGP_C3HHeJ_G0033186
protein coding gene Chr8:24304586-24331127 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033988
protein coding gene Chr8:25194120-25223588 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030938
protein coding gene Chr8:20598051-20621998 (+)
CAST/EiJ MGP_CASTEiJ_G0032512
protein coding gene Chr8:23759255-23784140 (+)
CBA/J MGP_CBAJ_G0033161
protein coding gene Chr8:26173658-26199573 (+)
DBA/2J MGP_DBA2J_G0033316
protein coding gene Chr8:23292580-23317252 (+)
FVB/NJ MGP_FVBNJ_G0033260
protein coding gene Chr8:23103790-23129218 (+)
LP/J MGP_LPJ_G0033405
protein coding gene Chr8:24193631-24218980 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033303
protein coding gene Chr8:25620870-25642897 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034007
protein coding gene Chr8:24047340-24070894 (+)
PWK/PhJ MGP_PWKPhJ_G0032223
protein coding gene Chr8:22937326-22961346 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032057
protein coding gene Chr8:23422417-23446904 (+)
WSB/EiJ MGP_WSBEiJ_G0032628
protein coding gene Chr8:24254417-24280844 (+)



Homology
more
  • Human Ortholog
    RNF170, ring finger protein 170
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RNF170, ring finger protein 170
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADSA, SNAX1
  • Links
    NCBI Gene ID: 81790
    neXtProt AC: NX_Q96K19
    UniProt: Q96K19

  • Chr Location
    8p11.21; chr8:42849637-42897288 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Rnf170 mouse models; 1 with human RNF170 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele develop progressive gait abnormalities that are more pronounced in dark conditions with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 77733 NCBI Gene Model | MGI Sequence Detail 24510 C57BL/6J ±  kb
transcript NM_029965 RefSeq | MGI Sequence Detail 3950 C57BL/6  
polypeptide Q8CBG9 UniProt | EBI | MGI Sequence Detail 286 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 51

    Microarray probesets 5
Other
Accession IDs
less
MGI:2142571
References
more
  • Summaries
    All 26
    Diseases 1
    Gene Ontology 2
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:226836 Kim Y, et al., Age-dependent gait abnormalities in mice lacking the Rnf170 gene linked to human autosomal-dominant sensory ataxia. Hum Mol Genet. 2015 Dec 20;24(25):7196-206

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory