Ehmt1
Gene Detail

Symbol Name ID

Ehmt1 euchromatic histone methyltransferase 1 MGI:1924933

Synonyms

9230102N17Rik, KMT1D, mKIAA1876

Feature Type

protein coding gene

Genetic Map

Chromosome 2

16.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:24790769-24919609 bp, - strand From VEGA annotation of GRCm38   128841 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11698  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: histone H3-K9 methyltransferase, Ehmt2 type
Gene Tree: Ehmt1

Human homologs

Human Homolog		EHMT1, euchromatic histone-lysine N-methyltransferase 1
NCBI Gene ID		79813
neXtProt AC		NX_Q9H9B1
Human Synonyms		bA188C12.1, Eu-HMTase1, EUHMTASE1, FP13812, GLP, GLP1, KMT1D
Human Chr (Location)		9q34.3; chr9:140513444-140730579 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human EHMT1

Alleles and phenotypes

All alleles(108) : Targeted(5) Gene trapped(102) Transgenic(1)
 

Heterozygous null mice display decreased exploration in a new environment. Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E10.

 
Human Diseases Modeled Using Mouse Ehmt1 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	chromatin modification, DNA methylation, ...
Component	chromosome, nucleus
Function	histone-lysine N-methyltransferase activity, histone methyltransferase activity (H3-K27 specific), ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (94)    Tissues (94)    Images (7)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(209)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(210) cDNA(209) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000012294 (Evidence)
Ensembl Gene Model	ENSMUSG00000036893 (Evidence)
Entrez Gene	77683 (Evidence)
UniGene	24176
DFCI	TC1573035, TC1585258, TC1601360, TC1603534, TC1618887, TC1623301, TC1755923
DoTS	DT.101409255, DT.101409258, DT.103579388, DT.110683843, DT.87068746, DT.91408469, DT.91434542
NIA Mouse Gene Index	U022367
EC	2.1.1.-, 2.1.1.43
Consensus CDS Project	CCDS15740.1
International Mouse Knockout Project Status	Ehmt1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012294	VEGA Gene Model | MGI Sequence Detail	128841	C57BL/6J
transcript	OTTMUST00000029249	VEGA | MGI Sequence Detail	5107	Not Applicable
polypeptide	OTTMUSP00000013205	VEGA | MGI Sequence Detail	1296	Not Applicable

All sequences(99) RefSeq(8) UniProt(10)

Polymorphisms

SNPs(559 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR007728	Pre-SET domain
InterPro	IPR003606	Pre-SET zinc-binding sub-group
InterPro	IPR001214	SET domain
Protein Ontology	PR:000006948	histone-lysine N-methyltransferase, H3 lysine-9 specific 5

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194983 Ideno H, et al., Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development. Gene Expr Patterns. 2013 Mar-Apr;13(3-4):84-90
All references(54)