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Ehmt1
Gene Detail
 Symbol
Name
ID
Ehmt1
euchromatic histone methyltransferase 1
MGI:1924933
Synonyms 9230102N17Rik, KMT1D, mKIAA1876
Feature Type protein coding gene
Genetic Map
Chromosome 2
16.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:24790769-24919609 bp, - strand
From VEGA annotation of GRCm38

  128841 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11698  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: histone H3-K9 methyltransferase, Ehmt2 type
Gene Tree: Ehmt1

Human
homologs
Human Homolog EHMT1, euchromatic histone-lysine N-methyltransferase 1
NCBI Gene ID 79813
neXtProt AC  NX_Q9H9B1
Human Synonyms  bA188C12.1, Eu-HMTase1, EUHMTASE1, FP13812, GLP, GLP1, KMT1D
Human Chr (Location)  9q34.3; chr9:137618992-137836127 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human EHMT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(109) : Gene trapped(102) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Heterozygous null mice display decreased exploration in a new environment. Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E10.
 
Human Diseases Modeled Using Mouse Ehmt1 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Ehmt1 interacts with 218 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (95 annotations)
Process chromatin modification, DNA methylation, ...
Component chromosome, cytoplasm, ...
Function 1-hydroxy-6-methoxypyrene methyltransferase activity, 1-hydroxypyrene methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (94)    Tissues (94)    Images (7)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(210)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(211) cDNA(210) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000012294 (Evidence)
Ensembl Gene ModelENSMUSG00000036893 (Evidence)
Entrez Gene77683 (Evidence)
UniGene24176
DFCITC1573035, TC1585258, TC1601360, TC1603534, TC1618887, TC1623301, TC1755923
DoTSDT.101409255, DT.101409258, DT.103579388, DT.110683843, DT.87068746, DT.91408469, DT.91434542
NIA Mouse Gene IndexU022367
EC2.1.1.-, 2.1.1.43
Consensus CDS ProjectCCDS15740.1, CCDS59634.1, CCDS59635.1, CCDS59636.1
International Mouse Knockout Project StatusEhmt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012294 VEGA Gene Model | MGI Sequence Detail 128841 C57BL/6J ±  kb
transcript OTTMUST00000029249 VEGA | MGI Sequence Detail 5107 Not Applicable 
polypeptide OTTMUSP00000013205 VEGA | MGI Sequence Detail 1296 Not Applicable 

For the selected sequences
All sequences(124) RefSeq(31) UniProt(12)
Polymorphisms SNPs within 2kb(749 from dbSNP Build 137)    SNPs within 2kb including multiple locations(757)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR007728 Pre-SET domain
InterPro IPR003606 Pre-SET zinc-binding sub-group
InterPro IPR001214 SET domain
Protein Ontology PR:000006948 histone-lysine N-methyltransferase, H3 lysine-9 specific 5
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213022 Mozzetta C, et al., The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing. Mol Cell. 2014 Jan 23;53(2):277-89
All references(63)
Disease annotation references (3)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory