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Tmem181a Gene Detail
Summary
  • Symbol
    Tmem181a
  • Name
    transmembrane protein 181A
  • Synonyms
    5930418K15Rik, C76977, Gpr178, mKIAA1423, Tmem181
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924356
    NCBI Gene: 77106
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:6307135-6358589 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 3.85 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    517 from dbSNP Build 142
  • Strain Annotations
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924356
 protein coding gene Chr17:6307001-6358589 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0022845
 protein coding gene Chr17:3512470-3579062 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023530
 protein coding gene Chr17:3646820-3653580 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021030
 protein coding gene Chr17:3139384-3177528 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0022924
 protein coding gene Chr17:3597377-3617073 (-)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0023550
 protein coding gene Chr17:3691015-3723816 (-)
PWK/PhJ MGP_PWKPhJ_G0022109
 protein coding gene Chr17:3546707-3590941 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021935
 protein coding gene Chr17:3407102-3450898 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TMEM181, transmembrane protein 181
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM181, transmembrane protein 181
  • Synonyms
    GPR178, KIAA1423
  • Links
    NCBI Gene ID: 57583
    UniProt: Q9P2C4

  • Chr Location
    6q25.3; chr6:158536436-158635433 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    366 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

Biological Process

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    18
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038141 Ensembl Gene Model | MGI Sequence Detail 51455 C57BL/6J ±  kb
    transcript ENSMUST00000232383 Ensembl | MGI Sequence Detail 4499 Not Applicable  
    polypeptide ENSMUSP00000156382 Ensembl | MGI Sequence Detail 515 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR040416 Transmembrane protein 181
      IPR047843 Wntless-like, transmembrane domain
    • GlyGen
      A0A338P7C9 3 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2147116
    References
    more
    • Summaries
      All 389
      Developmental Gene Expression 2
      Diseases 6
      Gene Ontology 2
      Phenotypes 366
    • Earliest
      J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
    • Latest
      J:374671 Brandebura AN, et al., Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down syndrome. Cell Rep. 2025 Oct 28;44(10):116300
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/30/2025
    MGI 6.24     		The Jackson Laboratory