About   Help   FAQ
Casc5 Gene Detail
Summary
  • Symbol
    Casc5
  • Name
    cancer susceptibility candidate 5
  • Synonyms
    2310043D08Rik, 5730505K17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923714
    NCBI Gene: 76464
  • Gene Overview
    MyGene.info: CASC5
Location & Maps
more
  • Sequence Map
    Chr2:119047119-119105501 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58383 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CASC5, cancer susceptibility candidate 5
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CASC5, cancer susceptibility candidate 5
    Orthology source: HomoloGene
  • Synonyms
    AF15Q14, CT29, D40, hKNL-1, hSpc105, KNL1, PPP1R55, Spc7
  • Links
    NCBI Gene ID: 57082
    neXtProt AC: NX_Q8NG31

  • Chr Location
    15q14; chr15:40594249-40662683 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CASC5 associations

Human Disease Mouse Models
       Microcephaly 4, Primary, Autosomal Recessive; MCPH4   OMIM: 604321
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    25
  • Radiation induced
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    2 involving Casc5
  • Incidental Mutations
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6. Mice homozygous for an ENU-induced allele exhibit possible embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015766 VEGA Gene Model | MGI Sequence Detail 58383 C57BL/6J ±  kb
transcript OTTMUST00000037462 VEGA | MGI Sequence Detail 7800 Not Applicable  
polypeptide OTTMUSP00000016789 VEGA | MGI Sequence Detail 2119 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    549 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000005050 protein CASC5
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 4
Other
Accession IDs
less
MGI:1917873
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:181686 Krenn V, et al., Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction. J Cell Biol. 2012 Feb 20;196(4):451-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/19/2016
MGI 6.03
The Jackson Laboratory