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Casc5
Gene Detail
Symbol

Name
ID
Casc5
cancer susceptibility candidate 5
MGI:1923714
Synonyms
2310043D08Rik, 5730505K17Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
59.85 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:119047119-119105501 bp, + strand
From VEGA annotation of GRCm38

  58383 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:44890  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: CASC5
Gene Tree: Casc5

Human
homologs
CASC5, cancer susceptibility candidate 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 57082
neXtProt AC: NX_Q8NG31

Human Synonyms: AF15Q14, CT29, D40, hKNL-1, hSpc105, KNL1, PPP1R55, Spc7

Human Chr (Location): 15q14; chr15:40594249-40662683 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CASC5

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Chemically induced (ENU)(1) Gene trapped(25) Targeted(2) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6. Mice homozygous for an ENU-induced allele exhibit possible embryonic lethality.
 
Interactions
Casc5 interacts with 278 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process attachment of spindle microtubules to kinetochore, cell cycle, ...
Component acrosomal vesicle, chromosome, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (20)    Tissues (1)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase casc5 ; ZFIN casc5    NEW 
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000015766 (Evidence)
Ensembl Gene Model ENSMUSG00000027326 (Evidence)
Entrez Gene 76464 (Evidence)
DFCI TC1628055, TC1589059, TC1584587
DoTS DT.55281860, DT.101710210, DT.481784, DT.101722957
NIA Mouse Gene Index U042346
Consensus CDS Project CCDS38203.1
International Mouse Phenotyping Consortium Status Casc5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015766 VEGA Gene Model | MGI Sequence Detail 58383 C57BL/6J ±  kb
transcript OTTMUST00000037462 VEGA | MGI Sequence Detail 7800 Not Applicable 
polypeptide OTTMUSP00000016789 VEGA | MGI Sequence Detail 2119 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(556 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000005050 protein CASC5
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:181686 Krenn V, et al., Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction. J Cell Biol. 2012 Feb 20;196(4):451-67
All references(34)
Other
accession IDs
MGI:1917873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory