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Knl1 Gene Detail
Summary
  • Symbol
    Knl1
  • Name
    kinetochore scaffold 1
  • Synonyms
    2310043D08Rik, 5730505K17Rik, Casc5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923714
    NCBI Gene: 76464
  • Gene Overview
    MyGene.info: KNL1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:119047038-119104829 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 59.85 cM, cytoband E5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    550 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923714
protein coding gene Chr2:119047038-119105501 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026330
protein coding gene Chr2:121778642-121838100 (+)
A/J MGP_AJ_G0026291
protein coding gene Chr2:116819635-116879967 (+)
AKR/J MGP_AKRJ_G0026270
protein coding gene Chr2:120090846-120150524 (+)
BALB/cJ MGP_BALBcJ_G0026304
protein coding gene Chr2:117084771-117144143 (+)
C3H/HeJ MGP_C3HHeJ_G0026050
protein coding gene Chr2:120560608-120622128 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026751
protein coding gene Chr2:125773902-125840258 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024131
protein coding gene Chr2:111873025-111932962 (+)
CAST/EiJ MGP_CASTEiJ_G0025512
protein coding gene Chr2:120862524-120921799 (+)
CBA/J MGP_CBAJ_G0026026
protein coding gene Chr2:130204649-130267854 (+)
DBA/2J MGP_DBA2J_G0026165
protein coding gene Chr2:116247527-116307495 (+)
FVB/NJ MGP_FVBNJ_G0026127
protein coding gene Chr2:115067198-115126781 (+)
LP/J MGP_LPJ_G0026266
protein coding gene Chr2:122089610-122153341 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026146
protein coding gene Chr2:134572507-134635553 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026806
protein coding gene Chr2:120215159-120275779 (+)
PWK/PhJ MGP_PWKPhJ_G0025248
protein coding gene Chr2:115801150-115860462 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025047
protein coding gene Chr2:119396807-119460560 (+)
WSB/EiJ MGP_WSBEiJ_G0025581
protein coding gene Chr2:121043946-121104767 (+)



Homology
more
  • Human Ortholog
    KNL1, kinetochore scaffold 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KNL1, kinetochore scaffold 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AF15Q14, CASC5, CT29, D40, hKNL-1, hSpc105, MCPH4, PPP1R55, Spc7
  • Links
    NCBI Gene ID: 57082
    neXtProt AC: NX_Q8NG31
    UniProt: Q8NG31

  • Chr Location
    15q15.1; chr15:40594012-40664342 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6. Mice homozygous for an ENU-induced allele exhibit possible embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76464 NCBI Gene Model | MGI Sequence Detail 57792 C57BL/6J ±  kb
    transcript NM_029617 RefSeq | MGI Sequence Detail 12901 C57BL/6  
    polypeptide Q66JQ7 UniProt | EBI | MGI Sequence Detail 1612 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR037388 Kinetochore scaffold 1
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917873
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:181686 Krenn V, et al., Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction. J Cell Biol. 2012 Feb 20;196(4):451-67

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory