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Casc5
Gene Detail
 Symbol
Name
ID
Casc5
cancer susceptibility candidate 5
MGI:1923714
Synonyms 2310043D08Rik, 5730505K17Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
59.85 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:119047119-119105501 bp, + strand
From VEGA annotation of GRCm38

  58383 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:44890  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Casc5

Human
homologs
Human Homolog CASC5, cancer susceptibility candidate 5
NCBI Gene ID 57082
neXtProt AC  NX_Q8NG31
Human Synonyms  AF15Q14, CT29, D40, hKNL-1, hSpc105, KNL1, PPP1R55, Spc7
Human Chr (Location)  15q14; chr15:40594249-40662683 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CASC5
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Chemically induced (ENU)(1) Gene trapped(25) Targeted(2) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6. Mice homozygous for an ENU-induced allele exhibit possible embryonic lethality.
 
Interactions
Casc5 interacts with 278 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process attachment of spindle microtubules to kinetochore, cell cycle, ...
Component acrosomal vesicle, chromosome, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (20)    Tissues (1)    Images (20)
Theiler Stages: 23
Assay TypeResults
RNA in situ 20
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000015766 (Evidence)
Ensembl Gene ModelENSMUSG00000027326 (Evidence)
Entrez Gene76464 (Evidence)
DFCITC1584587, TC1589059, TC1628055
DoTSDT.101710210, DT.101722957, DT.481784, DT.55281860
NIA Mouse Gene IndexU042346
Consensus CDS ProjectCCDS38203.1
International Mouse Knockout Project StatusCasc5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015766 VEGA Gene Model | MGI Sequence Detail 58383 C57BL/6J ±  kb
transcript OTTMUST00000037462 VEGA | MGI Sequence Detail 7800 Not Applicable 
polypeptide OTTMUSP00000016789 VEGA | MGI Sequence Detail 2119 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(7) UniProt(5)
Polymorphisms SNPs within 2kb(556 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000005050 protein CASC5
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:181686 Krenn V, et al., Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction. J Cell Biol. 2012 Feb 20;196(4):451-67
All references(35)
Other
accession IDs
MGI:1917873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory