Automated description from the Alliance of Genome Resources (Release 9.0.0)
Predicted to enable microtubule binding activity. Involved in attachment of meiotic spindle microtubules to kinetochore. Acts upstream of or within several processes, including chromosome segregation; phagocytosis; and positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in cytoplasm and kinetochore. Is expressed in cerebral cortex ventricular layer; telencephalon; and telencephalon ventricular layer. Human ortholog(s) of this gene implicated in autosomal recessive primary microcephaly; primary autosomal recessive microcephaly 4; and sarcoma. Orthologous to human KNL1 (kinetochore scaffold 1).
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