Knl1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Knl1
kinetochore scaffold 1
MGI:1923714

18 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Knl1^m1Anu/Knl1^m1Anu C57BL/6NCrlAnu-Knl1^m1Anu	embryonic lethality	J:104190
Knl1^{Tg(Tyr)2397HOve}/Knl1^{Tg(Tyr)2397HOve} FVB/N-Knl1^{Tg(Tyr)2397HOve}	embryonic lethality between implantation and somite formation, complete penetrance	J:175597
Knl1^{tm1b(EUCOMM)Hmgu}/Knl1⁺ C57BL/6N-Knl1^{tm1b(EUCOMM)Hmgu}/Ieg	impaired glucose tolerance	J:211773
Knl1^{tm1b(EUCOMM)Hmgu}/Knl1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Knl1^{tm1b(EUCOMM)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773
Knl1^{tm1c(EUCOMM)Hmgu}/Knl1^{tm1c(EUCOMM)Hmgu} Emx1^tm1(cre)Krj/Emx1⁺ involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6N	decreased neuron number	J:278483
	microcephaly	J:278483
	telencephalon hypoplasia	J:278483
Knl1^{tm1c(EUCOMM)Hmgu}/Knl1^{tm1c(EUCOMM)Hmgu} Tg(GFAP-cre)25Mes/0 involves: 129S4/SvJaeSor * C57BL/6N * FVB/N	abnormal double-strand DNA break repair	J:278483
	abnormal mitotic cytokinesis	J:278483
	absent corpus callosum	J:278483
	decreased body size	J:278483
	decreased neuron number	J:278483
	decreased neuronal precursor cell number	J:278483
	decreased survivor rate	J:278483
	increased apoptosis	J:278483
	microcephaly	J:278483
	microgliosis	J:278483
	postnatal lethality, incomplete penetrance	J:278483
	premature neuronal precursor differentiation	J:278483
	telencephalon hypoplasia	J:278483
	thin cortical plate	J:278483

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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