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Tgds Gene Detail
Summary
  • Symbol
    Tgds
  • Name
    TDP-glucose 4,6-dehydratase
  • Synonyms
    2610017J16Rik, 2610025M23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923605
    NCBI Gene: 76355
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:118349323-118370167 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 61.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    275 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923605
protein coding gene Chr14:118349323-118370177 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021647
protein coding gene Chr14:115676734-115697752 (-)
A/J MGP_AJ_G0021606
protein coding gene Chr14:111270524-111291380 (-)
AKR/J MGP_AKRJ_G0021582
protein coding gene Chr14:114886375-114907225 (-)
BALB/cJ MGP_BALBcJ_G0021612
protein coding gene Chr14:111814325-111835504 (-)
C3H/HeJ MGP_C3HHeJ_G0021390
protein coding gene Chr14:114761897-114784474 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022052
protein coding gene Chr14:120178898-120201378 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019591
protein coding gene Chr14:107342636-107363473 (-)
CAST/EiJ MGP_CASTEiJ_G0020906
protein coding gene Chr14:112593785-112614911 (-)
CBA/J MGP_CBAJ_G0021358
protein coding gene Chr14:124782598-124805549 (-)
DBA/2J MGP_DBA2J_G0021481
protein coding gene Chr14:111195612-111216450 (-)
FVB/NJ MGP_FVBNJ_G0021459
protein coding gene Chr14:109528459-109549684 (-)
LP/J MGP_LPJ_G0021549
protein coding gene Chr14:116715298-116737090 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021486
protein coding gene Chr14:129871283-129893168 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022075
protein coding gene Chr14:114346353-114367188 (-)
PWK/PhJ MGP_PWKPhJ_G0020650
protein coding gene Chr14:108181054-108202373 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020488
protein coding gene Chr14:110597407-110619578 (-)
WSB/EiJ MGP_WSBEiJ_G0020961
protein coding gene Chr14:115143973-115165672 (-)



Homology
more
  • Human Ortholog
    TGDS, TDP-glucose 4,6-dehydratase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGDS, TDP-glucose 4,6-dehydratase
  • Synonyms
    CATMANS, SDR2E1, TDPGD
  • Links
    NCBI Gene ID: 23483
    neXtProt AC: NX_O95455
    UniProt: O95455

  • Chr Location
    13q32.1; chr13:94574054-94596273 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human TGDS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit micrognathia and cleft palate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022130 Ensembl Gene Model | MGI Sequence Detail 20845 C57BL/6J ±  kb
    transcript ENSMUST00000022727 Ensembl | MGI Sequence Detail 1682 Not Applicable  
    polypeptide ENSMUSP00000022727 Ensembl | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 35

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917161, MGI:2145686
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:263533 Geister KA, et al., Optimizing Genomic Methods for Mapping and Identification of Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice. G3 (Bethesda). 2018 Feb 2;8(2):401-409

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory