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Smurf1
Gene Detail
Symbol

Name
ID
Smurf1
SMAD specific E3 ubiquitin protein ligase 1
MGI:1923038
Synonyms
4930431E10Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
84.83 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:144876495-144965847 bp, - strand
From VEGA annotation of GRCm38

  89353 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10712  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Smurf1

Human
homologs
Human Homolog SMURF1, SMAD specific E3 ubiquitin protein ligase 1
NCBI Gene ID 57154
neXtProt AC  NX_Q9HCE7
Human Chr (Location)  7q22.1; chr7:99027435-99144120 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(37) : Gene trapped(33) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for one knock-out allele display increased osteoblast function, bone density, and thickness of the cortical bone in long bones. Mice homozygous for a different knock-out allele are viable and only display gastrulation defects in combination with a Smurf2 knock-out allele.
 
Interactions
Smurf1 interacts with 319 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process BMP signaling pathway, cell differentiation, ...
Component axon, cytoplasm, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (107)    Tissues (38)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 97
RT-PCR 6
cDNA source data(122)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(124) cDNA(122) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021547 (Evidence)
Ensembl Gene ModelENSMUSG00000038780 (Evidence)
Entrez Gene75788 (Evidence)
UniGene27735
DFCITC1581603, TC1609975, TC1619251
DoTSDT.101397189, DT.110667255, DT.97410171
NIA Mouse Gene IndexU026939
EC6.3.2.-
Consensus CDS ProjectCCDS39380.1, CCDS39381.1
International Mouse Knockout Project StatusSmurf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021547 VEGA Gene Model | MGI Sequence Detail 89353 C57BL/6J ±  kb
transcript OTTMUST00000051097 VEGA | MGI Sequence Detail 5420 Not Applicable 
polypeptide OTTMUSP00000024000 VEGA | MGI Sequence Detail 757 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(18) UniProt(5)
Polymorphisms
SNPs within 2kb(429 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR024928 E3 ubiquitin-protein ligase, SMURF1 type
InterPro IPR000569 HECT
InterPro IPR001202 WW domain
Protein Ontology PR:000000361 smad ubiquitination regulatory factor 1
References
(Earliest) J:114795 Zhu H, et al., A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature. 1999 Aug 12;400(6745):687-93
(Latest) J:212159 Pabbisetty SK, et al., KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9579-84
All references(52)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory