Smurf1
Gene Detail

Symbol Name ID

Smurf1 SMAD specific E3 ubiquitin protein ligase 1 MGI:1923038

Synonyms

4930431E10Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 5

84.83 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:144876495-144965847 bp, - strand From VEGA annotation of GRCm38   89353 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10712  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Smurf1

Human homologs

Human Homolog		SMURF1, SMAD specific E3 ubiquitin protein ligase 1
NCBI Gene ID		57154
neXtProt AC		NX_Q9HCE7
Human Chr (Location)		7q22.1; chr7:98625058-98741743 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(37) : Targeted(4) Gene trapped(33)
 

Mice homozygous for one knock-out allele display increased osteoblast function, bone density, and thickness of the cortical bone in long bones. Mice homozygous for a different knock-out allele are viable and only display gastrulation defects in combination with a Smurf2 knock-out allele.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	BMP signaling pathway, cell differentiation, ...
Component	axon part, cytoplasm, ...
Function	activin binding, I-SMAD binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (107)    Tissues (37)    Images (25)
Theiler Stages: 18, 19, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	97
RT-PCR	6

cDNA source data(121)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(123) cDNA(121) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000021547 (Evidence)
Ensembl Gene Model	ENSMUSG00000038780 (Evidence)
Entrez Gene	75788 (Evidence)
UniGene	27735
DFCI	TC1581603, TC1609975, TC1619251
DoTS	DT.101397189, DT.110667255, DT.97410171
NIA Mouse Gene Index	U026939
EC	6.3.2.-
Consensus CDS Project	CCDS39380.1, CCDS39381.1
International Mouse Knockout Project Status	Smurf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021547	VEGA Gene Model | MGI Sequence Detail	89353	C57BL/6J
transcript	OTTMUST00000051097	VEGA | MGI Sequence Detail	5420	Not Applicable
polypeptide	OTTMUSP00000024000	VEGA | MGI Sequence Detail	757	Not Applicable

All sequences(46) RefSeq(4) UniProt(5)

Polymorphisms

SNPs(327 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR018029	C2 membrane targeting protein
InterPro	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
InterPro	IPR000569	HECT
InterPro	IPR001202	WW/Rsp5/WWP
Protein Ontology	PR:000000361	smad ubiquitination regulatory factor 1

References

(Earliest) J:114795 Zhu H, et al., A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature. 1999 Aug 12;400(6745):687-93
(Latest) J:188920 Vijayaraj P, et al., Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis. Development. 2012 Nov;139(21):3973-85
All references(48)