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Smurf1
Gene Detail
Symbol

Name
ID
Smurf1
SMAD specific E3 ubiquitin protein ligase 1
MGI:1923038
Synonyms
4930431E10Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
84.83 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:144876495-144965847 bp, - strand
From VEGA annotation of GRCm38

  89353 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10712  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SMURF1
Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Smurf1

Human
homologs
SMURF1, SMAD specific E3 ubiquitin protein ligase 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 57154
neXtProt AC: NX_Q9HCE7

Human Chr (Location): 7q22.1; chr7:99027435-99144120 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(37) : Gene trapped(33) Targeted(4)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for one knock-out allele display increased osteoblast function, bone density, and thickness of the cortical bone in long bones. Mice homozygous for a different knock-out allele are viable and only display gastrulation defects in combination with a Smurf2 knock-out allele.
 
Interactions
Smurf1 interacts with 318 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (107)    Tissues (38)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 97
RT-PCR 6
cDNA source data(122)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100491582 ; ZFIN smurf1    NEW 
Molecular
reagents
All nucleic(124) cDNA(122) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000021547 (Evidence)
Ensembl Gene Model ENSMUSG00000038780 (Evidence)
Entrez Gene 75788 (Evidence)
UniGene 27735
DFCI TC1609975, TC1581603, TC1619251
DoTS DT.101397189, DT.110667255, DT.97410171
NIA Mouse Gene Index U026939
EC 6.3.2.-
Consensus CDS Project CCDS39380.1, CCDS39381.1
International Mouse Phenotyping Consortium Status Smurf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021547 VEGA Gene Model | MGI Sequence Detail 89353 C57BL/6J ±  kb
transcript OTTMUST00000051097 VEGA | MGI Sequence Detail 5420 Not Applicable 
polypeptide OTTMUSP00000024000 VEGA | MGI Sequence Detail 757 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(429 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000569 HECT
InterPro IPR001202 WW domain
Protein Ontology PR:000000361 E3 ubiquitin-protein ligase SMURF1
References
(Earliest) J:114795 Zhu H, et al., A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature. 1999 Aug 12;400(6745):687-93
(Latest) J:212159 Pabbisetty SK, et al., KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9579-84
All references(53)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory