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Nhej1 Gene Detail
Summary
  • Symbol
    Nhej1
  • Name
    nonhomologous end-joining factor 1
  • Synonyms
    1700029B21Rik, cernunnos, XLF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922820
    NCBI Gene: 75570
  • Gene Overview
    MyGene.info: NHEJ1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74967346-75125226 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.56 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    457 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922820
protein coding gene Chr1:74967139-75125226 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016169
protein coding gene Chr1:75585090-75683850 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0016560
protein coding gene Chr1:78526947-78638056 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014281
protein coding gene Chr1:68513951-68608337 (-)
CAST/EiJ MGP_CASTEiJ_G0015522
protein coding gene Chr1:74639104-74740558 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0016015
protein coding gene Chr1:71465936-71562334 (-)
LP/J MGP_LPJ_G0016084
protein coding gene Chr1:76703418-76810009 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016035
protein coding gene Chr1:84457101-84552722 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016607
protein coding gene Chr1:75041854-75142931 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0015087
protein coding gene Chr1:74410433-74505444 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    NHEJ1, non-homologous end joining factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NHEJ1, non-homologous end joining factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    XLF
  • Links
    NCBI Gene ID: 79840
    neXtProt AC: NX_Q9H9Q4
    UniProt: Q9H9Q4

  • Chr Location
    2q35; chr2:219075324-219160865 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    23 phenotypes from multigenic genotypes
    5 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
ES cells that are null homozygous are sensitive to ionizing radiation and have defects in DNA repair. Lymphocyte numbers are modestly decreased in null homozygous mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic 75570 NCBI Gene Model | MGI Sequence Detail 157881 C57BL/6J ±  kb
transcript NM_029342 RefSeq | MGI Sequence Detail 1415 C57BL/6  
polypeptide Q3KNJ2 UniProt | EBI | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR015381 XLF family
Molecular
Reagents
less
  • All nucleic 20
    cDNA 20

    Microarray probesets 4
References
more
  • Summaries
    All 57
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 27
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:265834 Hung PJ, et al., MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol Cell. 2018 Jul 19;71(2):332-342.e8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory