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Nhej1
Gene Detail
 Symbol
Name
ID
Nhej1
nonhomologous end-joining factor 1
MGI:1922820
Synonyms 1700029B21Rik, cernunnos, XLF
Feature Type protein coding gene
Genetic Map
Chromosome 1
38.56 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:74967139-75125200 bp, - strand
From VEGA annotation of GRCm38

  158062 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11714  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nhej1

Human
homologs
Human Homolog NHEJ1, nonhomologous end-joining factor 1
NCBI Gene ID 79840
neXtProt AC  NX_Q9H9Q4
Human Synonyms  XLF
Human Chr (Location)  2q35; chr2:219075324-219160865 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NHEJ1
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(9) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
ES cells that are null homozygous are sensitive to ionizing radiation and have defects in DNA repair. Lymphocyte numbers are modestly decreased in null homozygous mice.
 
Interactions
Nhej1 interacts with 88 markers (Mir19b-1, Mir19b-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process B cell differentiation, cellular response to DNA damage stimulus, ...
Component nonhomologous end joining complex, nucleus
Function DNA binding
External Resources: FuncBase
Expression
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021757 (Evidence)
Ensembl Gene ModelENSMUSG00000026162 (Evidence)
Entrez Gene75570 (Evidence)
UniGene442409
DFCITC1584526, TC1591098, TC1687358
DoTSDT.101366208, DT.94230437
NIA Mouse Gene IndexU021487
International Mouse Knockout Project StatusNhej1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021757 VEGA Gene Model | MGI Sequence Detail 158062 C57BL/6J ±  kb
transcript OTTMUST00000051645 VEGA | MGI Sequence Detail 1053 Not Applicable 
polypeptide OTTMUSP00000024345 VEGA | MGI Sequence Detail 165 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(461 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009089 DNA double-strand break repair and VJ recombination XRCC4, N-terminal
InterPro IPR015381 XLF/Cernunnos
Protein Ontology PR:000011199 non-homologous end-joining factor 1
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:194422 Vera G, et al., Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans. Mol Cell Biol. 2013 Feb;33(4):701-11
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory