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Nhej1
Gene Detail
Symbol

Name
ID
Nhej1
nonhomologous end-joining factor 1
MGI:1922820
Synonyms
1700029B21Rik, cernunnos, XLF
Feature Type
protein coding gene
Genetic Map
Chromosome 1
38.56 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:74967139-75125200 bp, - strand
From VEGA annotation of GRCm38

  158062 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11714  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NHEJ1
Gene Tree: Nhej1

Human
homologs
NHEJ1, nonhomologous end-joining factor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79840
neXtProt AC: NX_Q9H9Q4

Human Synonyms: XLF

Human Chr (Location): 2q35; chr2:219075324-219160865 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NHEJ1

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(9) Radiation induced(1) Targeted(2)
Genomic Mutations involving Nhej1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
ES cells that are null homozygous are sensitive to ionizing radiation and have defects in DNA repair. Lymphocyte numbers are modestly decreased in null homozygous mice.
 
Interactions
Nhej1 interacts with 87 markers (Mir19b-1, Mir19b-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process B cell differentiation, cellular response to DNA damage stimulus, ...
Component nonhomologous end joining complex, nucleus
Function DNA binding
External Resources: FuncBase
Expression
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nhej1    NEW 
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021757 (Evidence)
Ensembl Gene Model ENSMUSG00000026162 (Evidence)
Entrez Gene 75570 (Evidence)
UniGene 442409
DFCI TC1687358, TC1591098, TC1584526
DoTS DT.94230437, DT.101366208
NIA Mouse Gene Index U021487
International Mouse Phenotyping Consortium Status Nhej1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021757 VEGA Gene Model | MGI Sequence Detail 158062 C57BL/6J ±  kb
transcript OTTMUST00000051645 VEGA | MGI Sequence Detail 1053 Not Applicable 
polypeptide OTTMUSP00000024345 VEGA | MGI Sequence Detail 165 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(461 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009089 DNA double-strand break repair and VJ recombination XRCC4, N-terminal
InterPro IPR015381 XLF/Cernunnos
Protein Ontology PR:000011199 non-homologous end-joining factor 1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:214608 Avagyan S, et al., Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency. Blood. 2014 Sep 4;124(10):1622-5
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory