Nhej1
Gene Detail

Symbol Name ID

Nhej1 nonhomologous end-joining factor 1 MGI:1922820

Synonyms

1700029B21Rik, cernunnos, XLF

Feature Type

protein coding gene

Genetic Map

Chromosome 1

38.56 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:74967139-75046639 bp, - strand From VEGA annotation of GRCm38   79501 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11714  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nhej1

Human homologs

Human Homolog		NHEJ1, nonhomologous end-joining factor 1
NCBI Gene ID		79840
neXtProt AC		NX_Q9H9Q4
Human Synonyms		XLF
Human Chr (Location)		2q35; chr2:219940046-220025587 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NHEJ1

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)
 

ES cells that are null homozygous are sensitive to ionizing radiation and have defects in DNA repair. Lymphocyte numbers are modestly decreased in null homozygous mice.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	B cell differentiation, DNA recombination, ...
Component	nonhomologous end joining complex, nucleus
Function	DNA binding

External Resources: FuncBase

Expression

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(17)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000021757 (Evidence)
Ensembl Gene Model	ENSMUSG00000026162 (Evidence)
Entrez Gene	75570 (Evidence)
UniGene	482554
DFCI	TC1584526, TC1591098, TC1687358
DoTS	DT.101366208, DT.94230437
NIA Mouse Gene Index	U021487
International Mouse Knockout Project Status	Nhej1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021757	VEGA Gene Model | MGI Sequence Detail	79501	C57BL/6J
transcript	OTTMUST00000051645	VEGA | MGI Sequence Detail	1053	Not Applicable
polypeptide	OTTMUSP00000024345	VEGA | MGI Sequence Detail	165	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(315 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009089	DNA double-strand break repair and VJ recombination XRCC4, N-terminal
InterPro	IPR015381	XLF/Cernunnos
Protein Ontology	PR:000011199	non-homologous end-joining factor 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194422 Vera G, et al., Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans. Mol Cell Biol. 2013 Feb;33(4):701-11
All references(38)