Nhej1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nhej1
non-homologous end joining factor 1
MGI:1922820

15 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nhej1^tm1.1Ics/Nhej1⁺ involves: 129 * C57BL/6	decreased thymocyte number	J:194422
Nhej1^tm1.1Ics/Nhej1^tm1.1Ics involves: 129 * C57BL/6	abnormal T cell receptor V(D)J recombination	J:194422
	decreased lymphocyte cell number	J:194422
	decreased NK T cell number	J:194422
	decreased thymocyte number	J:194422
	increased sensitivity to induced cell death	J:194422
	increased thymocyte apoptosis	J:194422
Nhej1^tm1Fwa/Nhej1^tm1Fwa 129S6/SvEvTac-Nhej1^tm1Fwa	abnormal DNA repair	J:120145
	increased cellular sensitivity to gamma-irradiation	J:120145
	spontaneous chromosome breakage	J:120145
Nhej1^tm1Fwa/Nhej1^tm1Fwa involves: 129	abnormal class switch recombination	J:138774
	decreased IgG1 level	J:138774
	decreased IgG3 level	J:138774
	increased cellular sensitivity to gamma-irradiation	J:138774
	increased IgM level	J:138774
	spleen hypoplasia	J:138774
	spontaneous chromosome breakage	J:138774
	thymus hypoplasia	J:138774

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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