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Dhcr24 Gene Detail
Summary
  • Symbol
    Dhcr24
  • Name
    24-dehydrocholesterol reductase
  • Synonyms
    2310076D10Rik, 3-beta-hydroxysterol delta-24 reductase, 5830417J06Rik, mKIAA0018, seladin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922004
    NCBI Gene: 74754
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:106418279-106446310 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 49.67 cM, cytoband C7
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922004
protein coding gene Chr4:106418235-106446310 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028520
protein coding gene Chr4:107186104-107217307 (+)
A/J MGP_AJ_G0028483
protein coding gene Chr4:103365094-103393864 (+)
AKR/J MGP_AKRJ_G0028430
protein coding gene Chr4:105877168-105905449 (+)
BALB/cJ MGP_BALBcJ_G0028502
protein coding gene Chr4:103552550-103580899 (+)
C3H/HeJ MGP_C3HHeJ_G0028216
protein coding gene Chr4:106630651-106660365 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028942
protein coding gene Chr4:111058498-111090420 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026233
protein coding gene Chr4:98640493-98668239 (+)
CAST/EiJ MGP_CASTEiJ_G0027652
protein coding gene Chr4:104423881-104463566 (+)
CBA/J MGP_CBAJ_G0028185
protein coding gene Chr4:114644846-114672832 (+)
DBA/2J MGP_DBA2J_G0028333
protein coding gene Chr4:102981382-103010199 (+)
FVB/NJ MGP_FVBNJ_G0028301
protein coding gene Chr4:101839117-101867151 (+)
LP/J MGP_LPJ_G0028434
protein coding gene Chr4:107384751-107418150 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028327
protein coding gene Chr4:119974546-120007624 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028978
protein coding gene Chr4:106124643-106154070 (+)
PWK/PhJ MGP_PWKPhJ_G0027378
protein coding gene Chr4:101215435-101253879 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027202
protein coding gene Chr4:103503023-103533187 (+)
WSB/EiJ MGP_WSBEiJ_G0027733
protein coding gene Chr4:106299017-106328056 (+)



Homology
more
  • Human Ortholog
    DHCR24, 24-dehydrocholesterol reductase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHCR24, 24-dehydrocholesterol reductase
  • Synonyms
    DCE, Nbla03646, seladin-1, SELADIN1
  • Links
    NCBI Gene ID: 1718
    neXtProt AC: NX_Q15392
    UniProt: Q15392

  • Chr Location
    1p32.3; chr1:54849627-54887195 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human DHCR24 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 5 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
In spite of having almost no plasma or tissue cholesterol, homozygous mutant mice are largely viable and display a mild growth phenotype. Inactivation did impair prenatal viability as well as infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74754 NCBI Gene Model | MGI Sequence Detail 28032 C57BL/6J ±  kb
    transcript NM_053272 RefSeq | MGI Sequence Detail 3984 C57BL/6  
    polypeptide Q8VCH6 UniProt | EBI | MGI Sequence Detail 516 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 151
      cDNA 148
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1922840
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 9
      Gene Ontology 11
      Phenotypes 26
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:342532 Zhang WB, et al., DHCR24 reverses Alzheimer's disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice. Acta Neuropathol Commun. 2023 Jun 21;11(1):102

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory