About   Help   FAQ
Dhcr24
Gene Detail
 Symbol
Name
ID
Dhcr24
24-dehydrocholesterol reductase
MGI:1922004
Synonyms 2310076D10Rik, 3-beta-hydroxysterol delta-24 reductase, 5830417J06Rik, mKIAA0018, seladin-1
Feature Type protein coding gene
Genetic Map
Chromosome 4
49.67 cM, cytoband C7
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:106561038-106589113 bp, + strand
From VEGA annotation of GRCm38

  28076 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dhcr24

Human
homologs
Human Homolog DHCR24, 24-dehydrocholesterol reductase
NCBI Gene ID 1718
neXtProt AC  NX_Q15392
Human Synonyms  DCE, Nbla03646, seladin-1, SELADIN1
Human Chr (Location)  1p32.3; chr1:54849627-54887248 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DHCR24
Alleles
and
phenotypes
All alleles(14) : Targeted(3) Gene trapped(11)
 
In spite of having almost no plasma or tissue cholesterol, homozygous mutant mice are largely viable and display a mild growth phenotype. Inactivation did impair prenatal viability as well as infertility.
 
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process amyloid precursor protein catabolic process, cholesterol biosynthetic process, ...
Component cytoplasm, cytoskeleton, ...
Function catalytic activity, delta24-sterol reductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (431)    Tissues (172)    Images (49)
Theiler Stages: 19, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 423
RT-PCR 8
cDNA source data(146)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(149) cDNA(147) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000008196 (Evidence)
Ensembl Gene ModelENSMUSG00000034926 (Evidence)
Entrez Gene74754 (Evidence)
UniGene133370
DFCITC1576565, TC1577656, TC1603669, TC1605111
DoTSDT.101737219, DT.488745, DT.94200583, DT.97414269
NIA Mouse Gene IndexU004587
EC1.3.1.72
Consensus CDS ProjectCCDS18420.1
International Mouse Knockout Project StatusDhcr24
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008196 VEGA Gene Model | MGI Sequence Detail 28076 C57BL/6J ±  kb
transcript OTTMUST00000018774 VEGA | MGI Sequence Detail 4028 Not Applicable 
polypeptide OTTMUSP00000008616 VEGA | MGI Sequence Detail 516 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
InterPro IPR016166 FAD-binding, type 2
InterPro IPR006094 FAD linked oxidase, N-terminal
Protein Ontology PR:000006453 delta(24)-sterol reductase
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:195928 Gilk SD, et al., Bacterial colonization of host cells in the absence of cholesterol. PLoS Pathog. 2013 Jan;9(1):e1003107
All references(51)
Other
accession IDs
MGI:1922840

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory