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Dhcr24
Gene Detail
Symbol

Name
ID
Dhcr24
24-dehydrocholesterol reductase
MGI:1922004
Synonyms
2310076D10Rik, 3-beta-hydroxysterol delta-24 reductase, 5830417J06Rik, mKIAA0018, seladin-1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
49.67 cM, cytoband C7
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:106561038-106589113 bp, + strand
From VEGA annotation of GRCm38

  28076 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DHCR24
Gene Tree: Dhcr24

Human
homologs
DHCR24, 24-dehydrocholesterol reductase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1718
neXtProt AC: NX_Q15392

Human Synonyms: DCE, Nbla03646, seladin-1, SELADIN1

Human Chr (Location): 1p32.3; chr1:54849627-54887248 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DHCR24

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Genomic Mutations involving Dhcr24 (1)
Incidental mutations (data from APF )
 
In spite of having almost no plasma or tissue cholesterol, homozygous mutant mice are largely viable and display a mild growth phenotype. Inactivation did impair prenatal viability as well as infertility.
 
Interactions
Dhcr24 interacts with 235 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process amyloid precursor protein catabolic process, cholesterol biosynthetic process, ...
Component cytoplasm, cytoskeleton, ...
Function catalytic activity, delta24(24-1) sterol reductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (431)    Tissues (172)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 423
RT-PCR 8
cDNA source data(146)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase dhcr24    NEW 
Molecular
reagents
All nucleic(149) cDNA(147) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000008196 (Evidence)
Ensembl Gene Model ENSMUSG00000034926 (Evidence)
Entrez Gene 74754 (Evidence)
UniGene 133370
DFCI TC1576565, TC1577656, TC1603669, TC1605111
DoTS DT.101737219, DT.488745, DT.94200583, DT.97414269
NIA Mouse Gene Index U004587
EC 1.3.1.72
Consensus CDS Project CCDS18420.1
International Mouse Phenotyping Consortium Status Dhcr24
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008196 VEGA Gene Model | MGI Sequence Detail 28076 C57BL/6J ±  kb
transcript OTTMUST00000018774 VEGA | MGI Sequence Detail 4028 Not Applicable 
polypeptide OTTMUSP00000008616 VEGA | MGI Sequence Detail 516 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
InterPro IPR016166 FAD-binding, type 2
InterPro IPR006094 FAD linked oxidase, N-terminal
Protein Ontology PR:000006453 delta(24)-sterol reductase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:214998 Tint GS, et al., Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed. Dev Neurosci. 2014;36(2):132-42
All references(52)
Other
accession IDs
MGI:1922840

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory