Dhcr24
Gene Detail

Symbol

Name
ID

Dhcr24
24-dehydrocholesterol reductase
MGI:1922004

Synonyms

2310076D10Rik, 3-beta-hydroxysterol delta-24 reductase, 5830417J06Rik, mKIAA0018, seladin-1

Feature Type

protein coding gene

Genetic Map

Chromosome 4
49.67 cM, cytoband C7
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:106561038-106589113 bp, + strand From VEGA annotation of GRCm38   28076 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:8850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dhcr24

Human
homologs

Human Homolog		DHCR24, 24-dehydrocholesterol reductase
NCBI Gene ID		1718
neXtProt AC		NX_Q15392
Human Synonyms		DCE, Nbla03646, seladin-1, SELADIN1
Human Chr (Location)		1p32.3; chr1:54849627-54887248 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human DHCR24

Mutations,
alleles, and
phenotypes

All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Genomic Mutations involving Dhcr24 (1)
Incidental mutations (data from APF )
 

In spite of having almost no plasma or tissue cholesterol, homozygous mutant mice are largely viable and display a mild growth phenotype. Inactivation did impair prenatal viability as well as infertility.

 

Interactions

Dhcr24 interacts with 236 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (46 annotations)

Process	amyloid precursor protein catabolic process, cholesterol biosynthetic process, ...
Component	cytoplasm, cytoskeleton, ...
Function	catalytic activity, delta24(24-1) sterol reductase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (431)    Tissues (172)    Images (49)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	423
RT-PCR	8

cDNA source data(146)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(149) cDNA(147) Primer pair(2)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000008196 (Evidence)
Ensembl Gene Model	ENSMUSG00000034926 (Evidence)
Entrez Gene	74754 (Evidence)
UniGene	133370
DFCI	TC1576565, TC1605111, TC1577656, TC1603669
DoTS	DT.488745, DT.101737219, DT.94200583, DT.97414269
NIA Mouse Gene Index	U004587
EC	1.3.1.72
Consensus CDS Project	CCDS18420.1
International Mouse Knockout Project Status	Dhcr24

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008196	VEGA Gene Model | MGI Sequence Detail	28076	C57BL/6J
transcript	OTTMUST00000018774	VEGA | MGI Sequence Detail	4028	Not Applicable
polypeptide	OTTMUSP00000008616	VEGA | MGI Sequence Detail	516	Not Applicable

All sequences(28) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(136 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR016169	CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
InterPro	IPR016166	FAD-binding, type 2
InterPro	IPR006094	FAD linked oxidase, N-terminal
Protein Ontology	PR:000006453	delta(24)-sterol reductase

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:214998 Tint GS, et al., Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed. Dev Neurosci. 2014;36(2):132-42
All references(53)

Other
accession IDs

MGI:1922840