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Crtc2 Gene Detail
Summary
  • Symbol
    Crtc2
  • Name
    CREB regulated transcription coactivator 2
  • Synonyms
    4632407F12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921593
    NCBI Gene: 74343
  • Gene Overview
    MyGene.info: CRTC2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90254163-90264125 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.21 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921593
protein coding gene Chr3:90253863-90264125 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027459
protein coding gene Chr3:90550243-90560205 (+)
A/J MGP_AJ_G0027423
protein coding gene Chr3:87538145-87548107 (+)
AKR/J MGP_AKRJ_G0027388
protein coding gene Chr3:89685942-89695904 (+)
BALB/cJ MGP_BALBcJ_G0027432
protein coding gene Chr3:87497712-87507674 (+)
C3H/HeJ MGP_C3HHeJ_G0027174
protein coding gene Chr3:89853034-89862996 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027878
protein coding gene Chr3:93956241-93966203 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025231
protein coding gene Chr3:83034514-83044432 (+)
CAST/EiJ MGP_CASTEiJ_G0026620
protein coding gene Chr3:90236787-90246747 (+)
CBA/J MGP_CBAJ_G0027149
protein coding gene Chr3:97193046-97203008 (+)
DBA/2J MGP_DBA2J_G0027286
protein coding gene Chr3:86907663-86917625 (+)
FVB/NJ MGP_FVBNJ_G0027254
protein coding gene Chr3:85244659-85254621 (+)
LP/J MGP_LPJ_G0027395
protein coding gene Chr3:91617975-91627937 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027275
protein coding gene Chr3:103392631-103402589 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027937
protein coding gene Chr3:89439192-89449154 (+)
PWK/PhJ MGP_PWKPhJ_G0026354
protein coding gene Chr3:86795801-86805841 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026174
protein coding gene Chr3:88611693-88621648 (+)
WSB/EiJ MGP_WSBEiJ_G0026702
protein coding gene Chr3:89831636-89841594 (+)



Homology
more
  • Human Ortholog
    CRTC2, CREB regulated transcription coactivator 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CRTC2, CREB regulated transcription coactivator 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TORC2, TORC-2
  • Links
    NCBI Gene ID: 200186
    neXtProt AC: NX_Q53ET0
    UniProt: Q53ET0

  • Chr Location
    1q21.3; chr1:153947672-153958656 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased circulating corticosterone levels, hepatocyte secretion of glucose in response to glucagon, and glycogen levels in liver and muscle cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027936 Ensembl Gene Model | MGI Sequence Detail 9963 C57BL/6J ±  kb
    transcript ENSMUST00000029545 Ensembl | MGI Sequence Detail 2747 Not Applicable  
    polypeptide ENSMUSP00000029545 Ensembl | MGI Sequence Detail 692 Not Applicable  
    For the selected sequence
    Protein
    Information
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    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005902 CREB-regulated transcription coactivator 2
    • PDB
    • InterPro Domains
      IPR024786 CREB-regulated transcription coactivator
      IPR024785 Transducer of regulated CREB activity, C-terminal
      IPR024784 Transducer of regulated CREB activity, middle domain
      IPR024783 Transducer of regulated CREB activity, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 51
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 15
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:252902 Kim JH, et al., CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11739-11744

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory