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Crtc2
Gene Detail
Symbol

Name
ID
Crtc2
CREB regulated transcription coactivator 2
MGI:1921593
Synonyms
4632407F12Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.21 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:90254163-90264125 bp, + strand
From VEGA annotation of GRCm38

  9963 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18765  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: CRTC2
Gene Tree: Crtc2

Human
homologs
CRTC2, CREB regulated transcription coactivator 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 200186
neXtProt AC: NX_Q53ET0

Human Synonyms: TORC2, TORC-2

Human Chr (Location): 1q21.3; chr1:153947672-153958656 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased circulating corticosterone levels, hepatocyte secretion of glucose in response to glucagon, and glycogen levels in liver and muscle cells.
 
Interactions
Crtc2 interacts with 119 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process gluconeogenesis, glucose homeostasis, ...
Component cytoplasm, extracellular exosome, ...
Function cAMP response element binding protein binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (102)    Tissues (102)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 102
cDNA source data(50)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) cDNA(50) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021260 (Evidence)
Ensembl Gene Model ENSMUSG00000027936 (Evidence)
Entrez Gene 74343 (Evidence)
UniGene 35627
DFCI TC1593930, TC1592919, TC1578079, TC1635990, TC1606845
DoTS DT.530692, DT.101734823, DT.101208456, DT.101371151, DT.101370891, DT.101370889
NIA Mouse Gene Index U003489
Consensus CDS Project CCDS38501.1
International Mouse Phenotyping Consortium Status Crtc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021260 VEGA Gene Model | MGI Sequence Detail 9963 C57BL/6J ±  kb
transcript OTTMUST00000050376 VEGA | MGI Sequence Detail 2747 Not Applicable 
polypeptide OTTMUSP00000023505 VEGA | MGI Sequence Detail 692 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024786 Transducer of regulated CREB activity
InterPro IPR024785 Transducer of regulated CREB activity, C-terminal
InterPro IPR024784 Transducer of regulated CREB activity, middle domain
InterPro IPR024783 Transducer of regulated CREB activity, N-terminal
Protein Ontology PR:000005902 CREB-regulated transcription coactivator 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:217540 Seok S, et al., Transcriptional regulation of autophagy by an FXR-CREB axis. Nature. 2014 Dec 4;516(7529):108-11
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory