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Crtc2 Gene Detail
Summary
  • Symbol
    Crtc2
  • Name
    CREB regulated transcription coactivator 2
  • Synonyms
    4632407F12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921593
    NCBI Gene: 74343
  • Gene Overview
    MyGene.info: CRTC2
Location & Maps
more
  • Sequence Map
    Chr3:90254163-90264125 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9963 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CRTC2, CREB regulated transcription coactivator 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CRTC2, CREB regulated transcription coactivator 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TORC2, TORC-2
  • Links
    NCBI Gene ID: 200186
    neXtProt AC: NX_Q53ET0

  • Chr Location
    1q21.3; chr1:153947672-153958656 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Crtc2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased circulating corticosterone levels, hepatocyte secretion of glucose in response to glucagon, and glycogen levels in liver and muscle cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021260 VEGA Gene Model | MGI Sequence Detail 9963 C57BL/6J ±  kb
transcript OTTMUST00000050376 VEGA | MGI Sequence Detail 2747 Not Applicable  
polypeptide OTTMUSP00000023505 VEGA | MGI Sequence Detail 692 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000005902 CREB-regulated transcription coactivator 2
  • InterPro Domains
    IPR024786 CREB-regulated transcription coactivator
    IPR024785 Transducer of regulated CREB activity, C-terminal
    IPR024784 Transducer of regulated CREB activity, middle domain
    IPR024783 Transducer of regulated CREB activity, N-terminal
Molecular
Reagents
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  • All nucleic 51
    cDNA 50
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 48
    Developmental Gene Expression 2
    Gene Ontology 12
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:225825 Han J, et al., The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature. 2015 Aug 13;524(7564):243-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory