Sequence Detail

ID/Version

Q3U182 Q3TA52 Q8BH09 (UniProt | EBI)

Last sequence update: 2008-02-05
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=CREB-regulated transcription coactivator 2;AltName: Full=Transducer of regulated cAMP response element-binding protein 2; Short=TORC-2; Short=Transducer of CREB protein 2;

Provider

SWISS-PROT

Sequence

Polypeptide 692 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Crtc2	CREB regulated transcription coactivator 2	25	98	3	13

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:102116 Koo SH, et al., The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature. 2005 Oct 20;437(7062):1109-11
J:104202 Shaw RJ, et al., The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 2005 Dec 9;310(5754):1642-6
J:126351 Dentin R, et al., Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature. 2007 Sep 20;449(7160):366-9
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:241518 Sonntag T, et al., Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members. PLoS One. 2017;12(2):e0173013
J:271695 Sonntag T, et al., Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. iScience. 2019 Jan 25;11:134-145
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87