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Hvcn1
Gene Detail
Symbol

Name
ID
Hvcn1
hydrogen voltage-gated channel 1
MGI:1921346
Synonyms
0610039P13Rik, BTS, mVSOP
Feature Type
protein coding gene
Genetic Map
Chromosome 5
62.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:122206804-122242297 bp, + strand
From VEGA annotation of GRCm38

  35494 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12535  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: voltage-dependent hydrogen channel 1
Gene Tree: Hvcn1

Human
homologs
Human Homolog HVCN1, hydrogen voltage-gated channel 1
NCBI Gene ID 84329
neXtProt AC  NX_Q96D96
Human Synonyms  HV1, VSOP
Human Chr (Location)  12q24.11; chr12:110648686-110698688 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(26) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele lack neutrophil and macrophage voltage-gated proton pumps.
 
Interactions
Hvcn1 interacts with 194 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022575 (Evidence)
Ensembl Gene ModelENSMUSG00000064267 (Evidence)
Entrez Gene74096 (Evidence)
NIA Mouse Gene IndexU006133
PDB3VMX, 3WKV, 3VYI, 3VMZ, 3VMY, 3VN0
Consensus CDS ProjectCCDS19644.1
International Mouse Knockout Project StatusHvcn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022575 VEGA Gene Model | MGI Sequence Detail 35494 C57BL/6J ±  kb
transcript OTTMUST00000054081 VEGA | MGI Sequence Detail 2805 Not Applicable 
polypeptide OTTMUSP00000025759 VEGA | MGI Sequence Detail 269 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000008846 voltage-gated hydrogen channel 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:195096 Sasaki M, et al., Autoimmune disorder phenotypes in Hvcn1-deficient mice. Biochem J. 2013 Mar 1;450(2):295-301
All references(40)
Other
accession IDs
MGI:2140895

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory