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Hvcn1
Gene Detail
Symbol

Name
ID
Hvcn1
hydrogen voltage-gated channel 1
MGI:1921346
Synonyms
0610039P13Rik, BTS, mVSOP
Feature Type
protein coding gene
Genetic Map
Chromosome 5
62.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:122206804-122242297 bp, + strand
From VEGA annotation of GRCm38

  35494 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12535  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HVCN1
Protein SuperFamily: voltage-dependent hydrogen channel 1
Gene Tree: Hvcn1

Human
homologs
HVCN1, hydrogen voltage gated channel 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 84329
neXtProt AC: NX_Q96D96

Human Synonyms: HV1, VSOP

Human Chr (Location): 12q24.11; chr12:110648686-110704950 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(26) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele lack neutrophil and macrophage voltage-gated proton pumps.
 
Interactions
Hvcn1 interacts with 194 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hvcn1    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022575 (Evidence)
Ensembl Gene Model ENSMUSG00000064267 (Evidence)
Entrez Gene 74096 (Evidence)
NIA Mouse Gene Index U006133
PDB 3VMX, 3WKV, 3VMY, 3VMZ, 3VYI, 3VN0
Consensus CDS Project CCDS19644.1
International Mouse Phenotyping Consortium Status Hvcn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022575 VEGA Gene Model | MGI Sequence Detail 35494 C57BL/6J ±  kb
transcript OTTMUST00000054080 VEGA | MGI Sequence Detail 2790 Not Applicable 
polypeptide OTTMUSP00000025758 VEGA | MGI Sequence Detail 269 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000008846 voltage-gated hydrogen channel 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:210046 Kurokawa T, et al., Mapping of sites facing aqueous environment of voltage-gated proton channel at resting state: a study with PEGylation protection. Biochim Biophys Acta. 2014 Jan;1838(1 Pt B):382-7
All references(41)
Other
accession IDs
MGI:2140895

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory