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Grip1 Gene Detail
Summary
  • Symbol
    Grip1
  • Name
    glutamate receptor interacting protein 1
  • Synonyms
    4931400F03Rik, eb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921303
    NCBI Gene: 74053
  • Gene Overview
    MyGene.info: GRIP1
Location & Maps
more
  • Sequence Map
    Chr10:119454034-120087261 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      633228 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 67.33 cM, cytoband D2
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    GRIP1, glutamate receptor interacting protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRIP1, glutamate receptor interacting protein 1
    Orthology source: HomoloGene
  • Synonyms
    GRIP
  • Links
    NCBI Gene ID: 23426
    neXtProt AC: NX_Q9Y3R0

  • Chr Location
    12q14.3; chr12:66347398-67069267 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 12938
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GRIP1
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Grip1 mouse models; 1 with human GRIP1 associations

Human Disease Mouse Models
       Fraser Syndrome   OMIM: 219000 View 2 models
       Clubfoot, Congenital, with or without Deficiency of Long Bones and/or Mirror-Image Polydactyly; CCF   OMIM: 119800 View 1 model
Epidermolysis Bullosa Dystrophica, Autosomal Recessive; RDEB   OMIM: 226600 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 4 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    6 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Grip1
  • Incidental Mutations
Homozygous ablation of gene function results in embryonic lethality and blistering skin lesions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033545 VEGA Gene Model | MGI Sequence Detail 633228 C57BL/6J ±  kb
transcript OTTMUST00000084455 VEGA | MGI Sequence Detail 3532 Not Applicable  
polypeptide OTTMUSP00000045526 VEGA | MGI Sequence Detail 1127 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6007 from dbSNP Build 142
Protein
Information
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  • UniProt
    13 Sequences
  • Protein Ontology
    PR:000008254 glutamate receptor-interacting protein 1
  • PDB
  • InterPro Domains
    IPR030026 Glutamate receptor-interacting protein 1
    IPR001478 PDZ domain
Molecular
Reagents
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  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-9289, MGI:95274
References
more
  • Summaries
    All 66
    Developmental Gene Expression 10
    Diseases 4
    Gene Ontology 16
    Phenotypes 21
  • Earliest
    J:13412 Chapman DB, et al., Eye blebs (eb). Mouse News Lett. 1963;28:32
  • Latest
    J:226510 Tan HL, et al., GRIP1 is required for homeostatic regulation of AMPAR trafficking. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):10026-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory