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Grip1
Gene Detail
Symbol

Name
ID
Grip1
glutamate receptor interacting protein 1
MGI:1921303
Synonyms
4931400F03Rik, eb
Feature Type
protein coding gene
Genetic Map
Chromosome 10
67.33 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:119454034-120087261 bp, + strand
From VEGA annotation of GRCm38

  633228 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12938  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GRIP1
Gene Tree: Grip1

Human
homologs
GRIP1, glutamate receptor interacting protein 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23426
neXtProt AC: NX_Q9Y3R0

Human Synonyms: GRIP

Human Chr (Location): 12q14.3; chr12:66347398-67069267 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GRIP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous ablation of gene function results in embryonic lethality and blistering skin lesions.
 
Human Diseases Modeled in Mice Using Grip1 (3)    Mutations Annotated to Human Diseases (3)    Phenotype Images(6)
Interactions
Grip1 interacts with 326 markers (Mir1b, Mir7-1, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process dendrite development, nervous system development, ...
Component cell junction, cytoplasmic vesicle, ...
Function glucocorticoid receptor binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (7)    Tissues (2)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
RT-PCR 2
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase grip1 ; ZFIN grip1    NEW 
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(5)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033545 VEGA Gene Model | MGI Sequence Detail 633228 C57BL/6J ±  kb
transcript OTTMUST00000084455 VEGA | MGI Sequence Detail 3532 Not Applicable 
polypeptide OTTMUSP00000045526 VEGA | MGI Sequence Detail 1127 Not Applicable 

For the selected sequences
All sequences(151) RefSeq(41) UniProt(13)
Polymorphisms
SNPs within 2kb(6069 from dbSNP Build 137)    SNPs within 2kb including multiple locations(6071)
Protein-related
information
ResourceIDDescription
InterPro IPR030026 Glutamate receptor-interacting protein 1
InterPro IPR001478 PDZ domain
Protein Ontology PR:000008254 glutamate receptor-interacting protein 1
References
(Earliest) J:13412 Chapman DB, et al., Eye blebs (eb). Mouse News Lett. 1963;28:32
(Latest) J:219877 Lv K, et al., Trip6 promotes dendritic morphogenesis through dephosphorylated GRIP1-dependent myosin VI and F-actin organization. J Neurosci. 2015 Feb 11;35(6):2559-71
All references(67)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-9289, MGI:95274

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory