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Rspo3
Gene Detail
Symbol

Name
ID
Rspo3
R-spondin 3 homolog (Xenopus laevis)
MGI:1920030
Synonyms
2810459H04Rik, Cristin1, Thsd2
Feature Type
protein coding gene
Genetic Map
Chromosome 10
16.64 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:29453109-29535867 bp, - strand
From Ensembl annotation of GRCm38

  82759 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12484  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rspo3

Human
homologs
Human Homolog RSPO3, R-spondin 3
NCBI Gene ID 84870
neXtProt AC  NX_Q9BXY4
Human Synonyms  CRISTIN1, PWTSR, THSD2
Human Chr (Location)  6q22.33; chr6:127118699-127199481 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality during organogenesis, embryonic growth arrest, and impaired fetal placental vascular development. Mice homozygous for a conditional allele activated in limbs exhibit slight limb shortening.
 
Phenotype Images(3)
Interactions
Rspo3 interacts with 165 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process branching involved in labyrinthine layer morphogenesis, canonical Wnt signaling pathway, ...
Component extracellular region
Function frizzled binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (298)    Tissues (243)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 292
RT-PCR 6
cDNA source data(23)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000019880 (Evidence)
Entrez Gene72780 (Evidence)
UniGene45191
DFCITC1583754
DoTSDT.487446
NIA Mouse Gene IndexU031641
Consensus CDS ProjectCCDS23761.1
International Mouse Knockout Project StatusRspo3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019880 Ensembl Gene Model | MGI Sequence Detail 82759 C57BL/6J ±  kb
transcript ENSMUST00000092623 Ensembl | MGI Sequence Detail 2394 Not Applicable 
polypeptide ENSMUSP00000090287 Ensembl | MGI Sequence Detail 277 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(416 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR006212 Furin-like repeat
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000014332 R-spondin-3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:210988 Kawasaki M, et al., R-spondins/Lgrs expression in tooth development. Dev Dyn. 2014 Jun;243(6):844-51
All references(44)
Other
accession IDs
MGI:2143874

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory