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Rspo3
Gene Detail
Symbol

Name
ID
Rspo3
R-spondin 3 homolog (Xenopus laevis)
MGI:1920030
Synonyms
2810459H04Rik, Cristin1, Thsd2
Feature Type
protein coding gene
Genetic Map
Chromosome 10
16.64 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:29453109-29535867 bp, - strand
From Ensembl annotation of GRCm38

  82759 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12484  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RSPO3
Gene Tree: Rspo3

Human
homologs
RSPO3, R-spondin 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 84870
neXtProt AC: NX_Q9BXY4

Human Synonyms: CRISTIN1, PWTSR, THSD2

Human Chr (Location): 6q22.33; chr6:127118903-127199481 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality during organogenesis, embryonic growth arrest, and impaired fetal placental vascular development. Mice homozygous for a conditional allele activated in limbs exhibit slight limb shortening.
 
Phenotype Images(3)
Interactions
Rspo3 interacts with 165 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process angiogenesis, branching involved in labyrinthine layer morphogenesis, ...
Component extracellular region, extracellular space
Function frizzled binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (298)    Tissues (243)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 292
RT-PCR 6
cDNA source data(23)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA RSPO3 ; Xenbase rspo3 ; ZFIN rspo3    NEW 
Molecular
reagents
All nucleic(26) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000019880 (Evidence)
Entrez Gene 72780 (Evidence)
UniGene 45191
DFCI TC1583754
DoTS DT.487446
NIA Mouse Gene Index U031641
Consensus CDS Project CCDS23761.1
International Mouse Phenotyping Consortium Status Rspo3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019880 Ensembl Gene Model | MGI Sequence Detail 82759 C57BL/6J ±  kb
transcript ENSMUST00000092623 Ensembl | MGI Sequence Detail 2394 Not Applicable 
polypeptide ENSMUSP00000090287 Ensembl | MGI Sequence Detail 277 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(416 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR006212 Furin-like repeat
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000014332 R-spondin-3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
All references(48)
Other
accession IDs
MGI:2143874

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory