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Rspo3 Gene Detail
Summary
  • Symbol
    Rspo3
  • Name
    R-spondin 3
  • Synonyms
    2810459H04Rik, Cristin1, Thsd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920030
    NCBI Gene: 72780
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:29329102-29411863 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 16.64 cM, cytoband A4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2420 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920030
 protein coding gene Chr10:29328412-29411863 (-)
129S1/SvImJ ENSMUSG00200008537
 protein coding gene Chr10:26171161-26254613 (-)
A/J ENSMUSG00195013714
 protein coding gene Chr10:26453088-26536542 (-)
AKR/J ENSMUSG00220010720
 protein coding gene Chr10:26147753-26231208 (-)
BALB/cJ ENSMUSG00180017336
 protein coding gene Chr10:26578186-26661645 (-)
C3H/HeJ ENSMUSG00175023719
 protein coding gene Chr10:26314120-26397566 (-)
C57BL/6NJ ENSMUSG00215009622
 protein coding gene Chr10:26126367-26209822 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015210
 protein coding gene Chr10:25319828-25404353 (-)
CAST/EiJ ENSTCUG00005012901
 protein coding gene Chr10:25959240-26043812 (-)
CBA/J ENSMUSG00210023346
 protein coding gene Chr10:26260814-26344274 (-)
DBA/2J ENSMUSG00185006969
 protein coding gene Chr10:26413492-26496942 (-)
FVB/NJ ENSMUSG00205009355
 protein coding gene Chr10:26399404-26482848 (-)
JF1/MsJ ENSUMUG00000015617
 protein coding gene Chr10:26221330-26304688 (-)
LP/J ENSMUSG00230009479
 protein coding gene Chr10:28181559-28265009 (-)
NOD/ShiLtJ ENSMUSG00190014826
 protein coding gene Chr10:26518744-26602204 (-)
NZO/HlLtJ ENSMUSG00225033135
 protein coding gene Chr10:32440535-32523983 (-)
PWK/PhJ ENSLUMG00010009983
 protein coding gene Chr10:26080341-26163698 (-)
SPRET/EiJ ENSMSPG00010014042
 protein coding gene Chr10:27029546-27115133 (-)
WSB/EiJ ENSIUOG00005030475
 protein coding gene Chr10:25888294-25977405 (-)



Homology
more
  • Human Ortholog
    RSPO3, R-spondin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RSPO3, R-spondin 3
  • Synonyms
    CRISTIN1, PWTSR, THSD2
  • Links
    NCBI Gene ID: 84870
    UniProt: Q9BXY4

  • Chr Location
    6q22.33; chr6:127118663-127199481 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 5 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    3 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality during organogenesis, embryonic growth arrest, and impaired fetal placental vascular development. Mice homozygous for a conditional allele activated in limbs exhibit slight limb shortening.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1116
  • Tissues
    355
  • cDNA Data
    31
  • Literature Summary
    66
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72780 NCBI Gene Model | MGI Sequence Detail 82762 C57BL/6J ±  kb
    transcript NM_028351 RefSeq | MGI Sequence Detail 2411 C57BL/6  
    polypeptide Q2TJ95 UniProt | EBI | MGI Sequence Detail 277 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 31
      Primer pair 13
      Other 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143874
    References
    more
    • Summaries
      All 136
      Developmental Gene Expression 66
      Gene Ontology 11
      Phenotypes 36
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:367758 Sugimoto A, et al., Hepatic stellate cells control liver zonation, size and functions via R-spondin 3. Nature. 2025 Apr;640(8059):752-761
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory