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Rspo3 Gene Detail
Summary
  • Symbol
    Rspo3
  • Name
    R-spondin 3
  • Synonyms
    2810459H04Rik, Cristin1, Thsd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920030
    NCBI Gene: 72780
  • Gene Overview
    MyGene.info: RSPO3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:29453106-29535867 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 16.64 cM, cytoband A4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    416 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920030
protein coding gene Chr10:29452416-29535867 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017114
protein coding gene Chr10:27632550-27717411 (-)
A/J MGP_AJ_G0017091
protein coding gene Chr10:26794875-26878420 (-)
AKR/J MGP_AKRJ_G0017051
protein coding gene Chr10:27227759-27310347 (-)
BALB/cJ MGP_BALBcJ_G0017054
protein coding gene Chr10:26912478-26996090 (-)
C3H/HeJ MGP_C3HHeJ_G0016874
protein coding gene Chr10:27476145-27567327 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017512
protein coding gene Chr10:28465718-28552545 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015210
protein coding gene Chr10:25319828-25404353 (-)
CAST/EiJ MGP_CASTEiJ_G0016453
protein coding gene Chr10:27546929-27641280 (-)
CBA/J MGP_CBAJ_G0016848
protein coding gene Chr10:29820422-29908060 (-)
DBA/2J MGP_DBA2J_G0016953
protein coding gene Chr10:26513427-26596659 (-)
FVB/NJ MGP_FVBNJ_G0016948
protein coding gene Chr10:26122866-26205498 (-)
LP/J MGP_LPJ_G0017030
protein coding gene Chr10:27602796-27687654 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016978
protein coding gene Chr10:29927539-30058532 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017548
protein coding gene Chr10:27129751-27212941 (-)
PWK/PhJ MGP_PWKPhJ_G0016235
protein coding gene Chr10:26271994-26356954 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016019
protein coding gene Chr10:27084701-27172688 (-)
WSB/EiJ MGP_WSBEiJ_G0016516
protein coding gene Chr10:27280689-27370760 (-)



Homology
more
  • Human Ortholog
    RSPO3, R-spondin 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RSPO3, R-spondin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRISTIN1, PWTSR, THSD2
  • Links
    NCBI Gene ID: 84870
    neXtProt AC: NX_Q9BXY4
    UniProt: Q9BXY4

  • Chr Location
    6q22.33; chr6:127118671-127199481 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12484
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RSPO3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 5 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    3 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality during organogenesis, embryonic growth arrest, and impaired fetal placental vascular development. Mice homozygous for a conditional allele activated in limbs exhibit slight limb shortening.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72780 NCBI Gene Model | MGI Sequence Detail 82762 C57BL/6J ±  kb
    transcript NM_028351 RefSeq | MGI Sequence Detail 2411 C57BL/6  
    polypeptide Q2TJ95 UniProt | EBI | MGI Sequence Detail 277 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 26
      Primer pair 6
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143874
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 31
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:264603 Da Silva F, et al., Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4. Dev Biol. 2018 Sep 1;441(1):42-51

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory