About   Help   FAQ
Rspo3 Gene Detail
Summary
  • Symbol
    Rspo3
  • Name
    R-spondin 3
  • Synonyms
    2810459H04Rik, Cristin1, Thsd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920030
    NCBI Gene: 72780
Location & Maps
more
  • Sequence Map
    Chr10:29453109-29535867 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      82759 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RSPO3, R-spondin 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RSPO3, R-spondin 3
    Orthology source: HomoloGene
  • Synonyms
    CRISTIN1, PWTSR, THSD2
  • Links
    NCBI Gene ID: 84870
    neXtProt AC: NX_Q9BXY4

  • Chr Location
    6q22.33; chr6:127118903-127199481 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 12484
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RSPO3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 5 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    3 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Rspo3
  • Incidental Mutations
Mice homozygous for a null mutation display embryonic lethality during organogenesis, embryonic growth arrest, and impaired fetal placental vascular development. Mice homozygous for a conditional allele activated in limbs exhibit slight limb shortening.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019880 Ensembl Gene Model | MGI Sequence Detail 82759 C57BL/6J ±  kb
transcript ENSMUST00000092623 Ensembl | MGI Sequence Detail 2394 Not Applicable  
polypeptide ENSMUSP00000090287 Ensembl | MGI Sequence Detail 277 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    416 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 24
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143874
References
more
  • Summaries
    All 46
    Developmental Gene Expression 24
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory