Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables frizzled binding activity and heparin binding activity. Involved in blood vessel remodeling; positive regulation of non-canonical Wnt signaling pathway; and sprouting angiogenesis. Acts upstream of or within angiogenesis; branching involved in labyrinthine layer morphogenesis; and positive regulation of canonical Wnt signaling pathway. Located in extracellular region. Is expressed in several structures, including embryo ectoderm; genitourinary system; heart; limb; and skeleton. Orthologous to human RSPO3 (R-spondin 3).