Sequence Detail

ID/Version

Q2TJ95 A6H6M4 Q8BVW2 Q9CSB2 Q3SYI9 Q5R2V4 (UniProt | EBI)

Last sequence update: 2006-05-16
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=R-spondin-3;AltName: Full=Cabriolet;AltName: Full=Cysteine-rich and single thrombospondin domain-containing protein 1 {ECO:0000303|PubMed:16543246}; Short=Cristin-1 {ECO:0000303|PubMed:16543246};AltName: Full=Nucleopondin {ECO:000030

Provider

SWISS-PROT

Sequence

Polypeptide 277 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rspo3	R-spondin 3	15	131	3	8

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113117 Nam JS, et al., Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J Biol Chem. 2006 May 12;281(19):13247-57
J:198905 Carmon KS, et al., R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11452-7
J:229308 Scholz B, et al., Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling. Dev Cell. 2016 Jan 11;36(1):79-93