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Cic Gene Detail
Summary
  • Symbol
    Cic
  • Name
    capicua transcriptional repressor
  • Synonyms
    1200010B10Rik, mKIAA0306
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918972
    NCBI Gene: 71722
  • Gene Overview
    MyGene.info: CIC
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25267704-25294159 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918972
protein coding gene Chr7:25267656-25294159 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031859
protein coding gene Chr7:23722611-23749056 (+)
A/J MGP_AJ_G0031838
protein coding gene Chr7:23113978-23140419 (+)
AKR/J MGP_AKRJ_G0031767
protein coding gene Chr7:23655528-23681859 (+)
BALB/cJ MGP_BALBcJ_G0031845
protein coding gene Chr7:23322750-23352906 (+)
C3H/HeJ MGP_C3HHeJ_G0031564
protein coding gene Chr7:24088011-24117298 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032307
protein coding gene Chr7:24517811-24544673 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029362
protein coding gene Chr7:24535706-24562170 (+)
CAST/EiJ MGP_CASTEiJ_G0030904
protein coding gene Chr7:17553272-17582997 (+)
CBA/J MGP_CBAJ_G0031529
protein coding gene Chr7:25422450-25457594 (+)
DBA/2J MGP_DBA2J_G0031683
protein coding gene Chr7:23013847-23041746 (+)
FVB/NJ MGP_FVBNJ_G0031636
protein coding gene Chr7:23015440-23043542 (+)
LP/J MGP_LPJ_G0031762
protein coding gene Chr7:24027149-24055313 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031673
protein coding gene Chr7:25132147-25164474 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032339
protein coding gene Chr7:23361511-23389324 (+)
PWK/PhJ MGP_PWKPhJ_G0030628
protein coding gene Chr7:17954121-17980657 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030459
protein coding gene Chr7:14674699-14701171 (+)
WSB/EiJ MGP_WSBEiJ_G0031007
protein coding gene Chr7:23536618-23566702 (+)



Homology
more
  • Human Ortholog
    CIC, capicua transcriptional repressor
  • Vertebrate Orthologs
    5
  • Human Ortholog
    CIC, capicua transcriptional repressor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRD45
  • Links
    NCBI Gene ID: 23152
    neXtProt AC: NX_Q96RK0
    UniProt: Q96RK0

  • Chr Location
    19q13.2; chr19:42268537-42295796 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CIC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit partial postnatal lethality, decreased body size, and severe lung alveolarization defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005442 Ensembl Gene Model | MGI Sequence Detail 26456 C57BL/6J ±  kb
    transcript ENSMUST00000169266 Ensembl | MGI Sequence Detail 8221 Not Applicable  
    polypeptide ENSMUSP00000132351 Ensembl | MGI Sequence Detail 2510 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR032147 Domain of unknown function DUF4819
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 142
      Genomic 2
      cDNA 139
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:261279 Rousseaux MWC, et al., ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism. Neuron. 2018 Mar 21;97(6):1235-1243.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory