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Targeted Allele Detail
Symbol: Cictm1c(KOMP)Wtsi
Name: capicua transcriptional repressor; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5903084
Synonyms: Cicf, Cucflox
Gene: Cic  Location: Chr7:24967129-24993584 bp, + strand  Genetic Position: Chr7, 13.73 cM
Alliance: Cictm1c(KOMP)Wtsi page
IMPC: Cic gene page
Mutant Cell Line:  EPD0285_3_F07
Germline Transmission:  Earliest citation of germline transmission: J:240674
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Bact_P
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 25287449 of Chromosome 7. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site inserted into intron 8. A third loxP site is inserted in intron 11. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 9 to 11 floxed. (J:240674)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cic Mutation:  68 strains or lines available
Original:  J:240674 Lu HC, et al., Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans. Nat Genet. 2017 Apr;49(4):527-536
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory