Cic^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Cic^{tm1c(KOMP)Wtsi}
• Name: capicua transcriptional repressor; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5903084
• Synonyms: Cic^f, Cuc^flox
• Gene: Cic Location: Chr7:24967129-24993584 bp, + strand Genetic Position: Chr7, 13.73 cM
• Alliance: Cic^{tm1c(KOMP)Wtsi} page
• IMPC: Cic gene page

Mutation origin

• Mutant Cell Line: EPD0285_3_F07
• Germline Transmission: Earliest citation of germline transmission: J:240674
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 25287449 of Chromosome 7. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site inserted into intron 8. A third loxP site is inserted in intron 11. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 9 to 11 floxed. (J:240674)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cic Mutation: 68 strains or lines available

References

• Original: J:240674 Lu HC, et al., Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans. Nat Genet. 2017 Apr;49(4):527-536
• All: 9 reference(s)