Analysis Tools
nervous system
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• mice show a reduction in the number of cells expressing CUX1 and SATB2 in cortical layers 2-4
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Allele Symbol Allele Name Allele ID |
Cictm1c(KOMP)Wtsi targeted mutation 1c, Wellcome Trust Sanger Institute MGI:5903084 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show a reduction in the number of cells expressing CUX1 and SATB2 in cortical layers 2-4
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in a fear conditioning assay, mice exhibit reduced freezing, especially in the test of spatial context, indicating impaired learning and memory
• however, mice show normal social behavior in the three-chamber test
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• in the elevated plus-maze test, mice spend more time in the open arm and less in the closed arm, indicating reduced anxiety
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• mice cover a greater distance at a greater speed in the open-field test
• mice treated with a low dose of amphetamine show reduced hyperactivity
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• the hippocampal dentate gyrus shows decreased thickness at 20 weeks of age, however the CA1 and CA3 regions are normal
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• mice exhibit a transient increase of apoptosis in the upper layers of the cortex at P5 that is no longer seen at P10
• however, the corpus callosum appears normal
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• the number of CUX1+ neurons in layers 2-4 is reduced at 5 weeks
• numbers of CUX1+ and SATB2+ neurons in layers 2-4 of the cortex are normal at P0 but decline postnatally and by P10 are comparable to that at 5 weeks
• the numbers of progenitors and their proliferation rates in embryonic cortex are not different from wild-type
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• mice show reduced thickness of cortical layers 2-4 at 5 and 20 weeks of age, whereas thickness of layers 5 and 6 remains normal
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• layer 2/3 pyramidal neurons show reduced dendritic branching complexity in 5 week old mice
• however, layer 5 pyramidal neurons show normal dendritic branching
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• mice show a decrease in the probability of presynaptic neurotransmitter release
• however, basal synaptic transmission and long-term synaptic plasticity are normal
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| disease of mental health | DOID:150 | J:240674 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the resident-intruder test, mice behave more aggressively toward intruders, with more frequent and longer attack episodes
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• in the three-chamber test, mice interact less with other mice
• however, mice do not exhibit abnormal behavior in the open-field, elevated plus-maze, or fear conditioning assay
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• in the partition test, mice spend less time interacting with novel mice
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| N |
• no gross abnormalities or altered cellularity of Otp-lineage neurons are seen
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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