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Phenotypes Associated with This Genotype
involves: 129S2/SvPas * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cictm1c(KOMP)Wtsi mutation (1 available); any Cic mutation (68 available)
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• in a fear conditioning assay, mice exhibit reduced freezing, especially in the test of spatial context, indicating impaired learning and memory
• however, mice show normal social behavior in the three-chamber test
• in the elevated plus-maze test, mice spend more time in the open arm and less in the closed arm, indicating reduced anxiety
• mice cover a greater distance at a greater speed in the open-field test
• mice treated with a low dose of amphetamine show reduced hyperactivity

nervous system
• the hippocampal dentate gyrus shows decreased thickness at 20 weeks of age, however the CA1 and CA3 regions are normal
• mice exhibit a transient increase of apoptosis in the upper layers of the cortex at P5 that is no longer seen at P10
• however, the corpus callosum appears normal
• the number of CUX1+ neurons in layers 2-4 is reduced at 5 weeks
• numbers of CUX1+ and SATB2+ neurons in layers 2-4 of the cortex are normal at P0 but decline postnatally and by P10 are comparable to that at 5 weeks
• the numbers of progenitors and their proliferation rates in embryonic cortex are not different from wild-type
• mice show reduced thickness of cortical layers 2-4 at 5 and 20 weeks of age, whereas thickness of layers 5 and 6 remains normal
• layer 2/3 pyramidal neurons show reduced dendritic branching complexity in 5 week old mice
• however, layer 5 pyramidal neurons show normal dendritic branching
• mice show a decrease in the probability of presynaptic neurotransmitter release
• however, basal synaptic transmission and long-term synaptic plasticity are normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
disease of mental health DOID:150 J:240674

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory