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Vps35l Gene Detail
Summary
  • Symbol
    Vps35l
  • Name
    VPS35 endosomal protein sorting factor like
  • Synonyms
    2610029J22Rik, 9030624J02Rik, Vsp35l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918767
    NCBI Gene: 71517
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:118339401-118440712 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 63.61 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3690 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918767
 protein coding gene Chr7:118339401-118442189 (+)
129S1/SvImJ ENSMUSG00200021117
 protein coding gene Chr7:104851835-104955714 (+)
A/J ENSMUSG00195038135
 protein coding gene Chr7:109400152-109504512 (+)
AKR/J ENSMUSG00220020774
 protein coding gene Chr7:102833961-102936736 (+)
BALB/cJ ENSMUSG00180024525
 protein coding gene Chr7:106063431-106167782 (+)
C3H/HeJ ENSMUSG00175021663
 protein coding gene Chr7:106764342-106868224 (+)
C57BL/6NJ ENSMUSG00215035367
 protein coding gene Chr7:106005263-106108015 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030370
 protein coding gene Chr7:120920661-121022259 (+)
CAST/EiJ ENSTCUG00005037002
 protein coding gene Chr7:109348139-109452514 (+)
CBA/J ENSMUSG00210024383
 protein coding gene Chr7:106487680-106591570 (+)
DBA/2J ENSMUSG00185037519
 protein coding gene Chr7:110838289-110942182 (+)
FVB/NJ ENSMUSG00205016814
 protein coding gene Chr7:106467055-106569809 (+)
JF1/MsJ ENSUMUG00000039452
 protein coding gene Chr7:115899927-116003791 (+)
LP/J ENSMUSG00230033303
 protein coding gene Chr7:116937668-117045073 (+)
NOD/ShiLtJ ENSMUSG00190016842
 protein coding gene Chr7:106684917-106787670 (+)
NZO/HlLtJ ENSMUSG00225038217
 protein coding gene Chr7:115209365-115313716 (+)
PWK/PhJ ENSLUMG00010011712
 protein coding gene Chr7:105031111-105134702 (+)
SPRET/EiJ ENSMSPG00010008665
 protein coding gene Chr7:106237838-106339931 (+)
WSB/EiJ ENSIUOG00005010507
 protein coding gene Chr7:107365844-107467431 (+)



Homology
more
  • Human Ortholog
    VPS35L, VPS35 endosomal protein sorting factor like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS35L, VPS35 endosomal protein sorting factor like
  • Synonyms
    C16orf62, EC97, RTSC3
  • Links
    NCBI Gene ID: 57020
    UniProt: Q7Z3J2

  • Chr Location
    16p12.3; chr16:19555240-19706793 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Vps35l mouse models; 1 with human VPS35L associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout is early embryonic lethal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71517 NCBI Gene Model | MGI Sequence Detail 101312 C57BL/6J ±  kb
    transcript NM_027815 RefSeq | MGI Sequence Detail 3103 C57BL/6  
    polypeptide Q8BWQ6 UniProt | EBI | MGI Sequence Detail 963 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000060155 VPS35 endosomal protein-sorting factor-like
      (term hierarchy)
    • InterPro Domains
      IPR029705 VPS35 endosomal protein sorting factor-like
      IPR060266 VPS35 endosomal protein-sorting factor-like, N-terminal domain
      IPR064019 VPS35L, C-terminal domain
    • GlyGen
      Q8BWQ6 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1916502, MGI:6162263, MGI:6194628
    References
    more
    • Summaries
      All 36
      Diseases 1
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:379431 Kato K, et al., Ritscher-Schinzel syndrome can be characterized as an endosomal recyclinopathy. Sci Transl Med. 2025 Jul 2;17(805):eadt2426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory