Vps35l^em3Shis
Endonuclease-mediated Allele Detail

Summary

• Symbol: Vps35l^em3Shis
• Name: VPS35 endosomal protein sorting factor like; endonuclease-mediated mutation 3, Shinji Saitoh
• MGI ID: MGI:8316984
• Synonyms: Vps35l^flox
• Gene: Vps35l Location: Chr7:118339401-118440712 bp, + strand Genetic Position: Chr7, 63.61 cM, cytoband F3
• Alliance: Vps35l^em3Shis page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details:

  LoxP sites were inserted in introns 9 and 11 using sgRNAs and two ssODN templates with CRISPR/Cas9 technology. (J:379431)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vps35l Mutation: 62 strains or lines available

References

• Original: J:379431 Kato K, et al., Ritscher-Schinzel syndrome can be characterized as an endosomal recyclinopathy. Sci Transl Med. 2025 Jul 2;17(805):eadt2426
• All: 1 reference(s)