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Hdac8
Gene Detail
Symbol

Name
ID
Hdac8
histone deacetylase 8
MGI:1917565
Synonyms
2610007D20Rik
Feature Type
protein coding gene
Genetic Map
Chromosome X
45.28 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:102284639-102505359 bp, - strand
From VEGA annotation of GRCm38

  220721 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41274  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HDAC8
Protein SuperFamily: histone deacetylase class I, eukaryotic type
Gene Tree: Hdac8

Human
homologs
HDAC8, histone deacetylase 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55869
neXtProt AC: NX_Q9BY41

Human Synonyms: CDA07, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS

Human Chr (Location): Xq13; chrX:72329516-72573103 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HDAC8

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(7) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice hemizygous or homozygous for the null allele exhibit background sensitive defects in frontal and interparietal bone ossification. On a C57BL/6 background the phenotype is severe leading to death within 4-6 hours of birth from brain hemorrhaging.
 
Interactions
Hdac8 interacts with 102 markers (Mir1b, Mir10a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process chromatin modification, histone deacetylation, ...
Component cytoplasm, histone deacetylase complex, ...
Function histone deacetylase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (81)    Tissues (11)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
RT-PCR 36
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HDAC8 ; Xenbase hdac8 ; ZFIN hdac8    NEW 
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000017208 (Evidence)
Ensembl Gene Model ENSMUSG00000067567 (Evidence)
Entrez Gene 70315 (Evidence)
UniGene 328128
DFCI TC1585057
DoTS DT.55281883
NIA Mouse Gene Index U039588
EC 3.5.1.98
Consensus CDS Project CCDS41084.1
International Mouse Phenotyping Consortium Status Hdac8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017208 VEGA Gene Model | MGI Sequence Detail 220721 C57BL/6J ±  kb
transcript OTTMUST00000041672 VEGA | MGI Sequence Detail 1936 Not Applicable 
polypeptide OTTMUSP00000018717 VEGA | MGI Sequence Detail 377 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(14) UniProt(2)
Polymorphisms
SNPs within 2kb(418 from dbSNP Build 137)    SNPs within 2kb including multiple locations(424)
Protein-related
information
ResourceIDDescription
InterPro IPR003084 Histone deacetylase
InterPro IPR023801 Histone deacetylase domain
InterPro IPR000286 Histone deacetylase superfamily
Protein Ontology PR:000008487 histone deacetylase 8
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213843 Tiwari S, et al., Histone deacetylase expression patterns in developing murine optic nerve. BMC Dev Biol. 2014;14:30
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory