Hdac8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hdac8
histone deacetylase 8
MGI:1917565

27 phenotypes from 4 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hdac8^tm1.1Eno/Y H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129 * C57BL/6 * CBA * CD-1	failure of intramembranous bone ossification	J:150709
	frontal bone foramen	J:150709
	intracranial hemorrhage	J:150709
	neonatal lethality, incomplete penetrance	J:150709
Hdac8^tm1.1Eno/Hdac8^tm1.1Eno Tg(Zp3-cre)93Knw/0 involves: 129S6/SvEvTac * C57BL/6J	normal reproductive system phenotype	J:285736
Hdac8^tm1.1Eno/Hdac8^tm1.2Eno Tg(Ddx4-cre)1Dcas/0 involves: 129S6/SvEvTac * C57BL/6J * FVB	abnormal female meiosis	J:285736
	abnormal oocyte morphology	J:285736
	abnormal oogenesis	J:285736
	decreased litter size	J:285736
	normal embryo phenotype	J:285736
	reduced female fertility	J:285736
	normal reproductive system phenotype	J:285736
Hdac8^tm1.1Eno/Y Tg(Col1a1-cre)1Kry/0 involves: 129 * C57BL/6 * CD-1 * FVB/N	no abnormal phenotype detected	J:150709
Hdac8^tm1.1Eno/Y Tg(Col2a1-cre)1Bhr/0 involves: 129 * C57BL/6 * CD-1 * SJL	no abnormal phenotype detected	J:150709
Hdac8^tm1.1Eno/Y Twist2^tm1(cre)Dor/Twist2⁺ involves: 129 * C57BL/6 * CD-1 * SJL	no abnormal phenotype detected	J:150709
Hdac8^tm1.2Eno/Y involves: 129 * C57BL/6 * CD-1	decreased embryo weight	J:150709
	exencephaly	J:150709
	failure of intramembranous bone ossification	J:150709
	frontal bone foramen	J:150709
	intracranial hemorrhage	J:150709
	neonatal lethality, complete penetrance	J:150709
	neonatal lethality, incomplete penetrance	J:150709
Hdac8^tm1.2Eno/Hdac8⁺ involves: 129 * C57BL/6 * CD-1	decreased embryo weight	J:150709
	exencephaly	J:150709
	failure of intramembranous bone ossification	J:150709
	frontal bone foramen	J:150709
	genetic imprinting	J:150709
	intracranial hemorrhage	J:150709
	neonatal lethality, incomplete penetrance	J:150709
Hdac8^tm1.2Eno/Y involves: 129S6/SvEvTac * C57BL/6J	abnormal chromosome number	J:297059
	abnormal DNA repair	J:297059
	abnormal placenta junctional zone morphology	J:297059
	abnormal placenta physiology	J:297059
	abnormal spongiotrophoblast cell morphology	J:297059
	decreased embryo weight	J:297059
	increased placenta weight	J:297059
	postnatal lethality, incomplete penetrance	J:297059
	short forelimb	J:297059
Hdac8^tm1.2Eno/Hdac8⁺ Tg(CAG-Hdac8,-EGFP)1Eno/0 involves: 129 * C57BL/6 * C3H * CD-1	no abnormal phenotype detected	J:150709
Hdac8^tm1.2Eno/Hdac8^tm1.2Eno involves: 129 * C57BL/6 * CD-1	decreased embryo weight	J:150709
	exencephaly	J:150709
	failure of intramembranous bone ossification	J:150709
	frontal bone foramen	J:150709
	intracranial hemorrhage	J:150709
	neonatal lethality, complete penetrance	J:150709
	neonatal lethality, incomplete penetrance	J:150709
Hdac8^{tm1a(EUCOMM)Wtsi}/Y C57BL/6N-Hdac8^{tm1a(EUCOMM)Wtsi}/Wtsi	decreased body length	J:175295
	decreased bone mineral density	J:175295
Hdac8^{tm1a(EUCOMM)Wtsi}/Hdac8^{tm1a(EUCOMM)Wtsi} C57BL/6N-Hdac8^{tm1a(EUCOMM)Wtsi}/Wtsi	decreased bone mineral content	J:175295
	decreased bone mineral density	J:175295

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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