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Ace2
Gene Detail
 Symbol
Name
ID
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
MGI:1917258
Synonyms 2010305L05Rik
Feature Type protein coding gene
Genetic Map
Chromosome X
76.12 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:164139332-164188420 bp, + strand
From VEGA annotation of GRCm38

  49089 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ace2

Human
homologs
Human Homolog ACE2, angiotensin I converting enzyme 2
NCBI Gene ID 59272
neXtProt AC  NX_Q9BYF1
Human Synonyms  ACEH
Human Chr (Location)  Xp22; chrX:15561033-15602069 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this locus results in reduced cardiac contractility.
 
Interactions
Ace2 interacts with 177 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process angiotensin-mediated drinking behavior, proteolysis, ...
Component cell surface, extracellular region, ...
Function carboxypeptidase activity, endopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (84)    Tissues (55)    Images (23)
Theiler Stages: 21, 22, 23, 24, 26, 27
Assay TypeResults
RNA in situ 82
RT-PCR 2
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(23) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000019518 (Evidence)
Ensembl Gene ModelENSMUSG00000015405 (Evidence)
Entrez Gene70008 (Evidence)
UniGene13451
DFCITC1580851, TC1644033, TC1685826
DoTSDT.101250561, DT.101360881, DT.60106315, DT.94232004, DT.97360027
NIA Mouse Gene IndexU020383
EC3.4.17.23
Consensus CDS ProjectCCDS30518.1
International Mouse Knockout Project StatusAce2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019518 VEGA Gene Model | MGI Sequence Detail 49089 C57BL/6J ±  kb
transcript OTTMUST00000046614 VEGA | MGI Sequence Detail 3578 Not Applicable 
polypeptide OTTMUSP00000021053 VEGA | MGI Sequence Detail 805 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(155 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001548 Peptidase M2, peptidyl-dipeptidase A
Protein Ontology PR:000003622 angiotensin-converting enzyme 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209650 Alghamri MS, et al., Novel role of aminopeptidase-A in angiotensin-(1-7) metabolism post myocardial infarction. Am J Physiol Heart Circ Physiol. 2014 Apr 1;306(7):H1032-40
All references(69)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory