About   Help   FAQ
Ace2
Gene Detail
Symbol

Name
ID
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
MGI:1917258
Synonyms
2010305L05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome X
76.12 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:164139332-164188420 bp, + strand
From VEGA annotation of GRCm38

  49089 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ACE2
Gene Tree: Ace2

Human
homologs
ACE2, angiotensin I converting enzyme 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 59272
neXtProt AC: NX_Q9BYF1

Human Synonyms: ACEH

Human Chr (Location): Xp22; chrX:15494402-15602069 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this locus results in reduced cardiac contractility.
 
Interactions
Ace2 interacts with 177 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process angiotensin-mediated drinking behavior, negative regulation of ERK1 and ERK2 cascade, ...
Component cell surface, cytoplasm, ...
Function carboxypeptidase activity, endopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (84)    Tissues (55)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 82
RT-PCR 2
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ace2    NEW 
Molecular
reagents
All nucleic(25) cDNA(23) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000019518 (Evidence)
Ensembl Gene Model ENSMUSG00000015405 (Evidence)
Entrez Gene 70008 (Evidence)
UniGene 13451
DFCI TC1685826, TC1644033, TC1580851
DoTS DT.101360881, DT.101250561, DT.60106315, DT.94232004, DT.97360027
NIA Mouse Gene Index U020383
EC 3.4.17.23
Consensus CDS Project CCDS30518.1
International Mouse Phenotyping Consortium Status Ace2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019518 VEGA Gene Model | MGI Sequence Detail 49089 C57BL/6J ±  kb
transcript OTTMUST00000046613 VEGA | MGI Sequence Detail 3422 Not Applicable 
polypeptide OTTMUSP00000021052 VEGA | MGI Sequence Detail 805 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(155 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001548 Peptidase M2, peptidyl-dipeptidase A
Protein Ontology PR:000003622 angiotensin-converting enzyme 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:219539 Sahara M, et al., Deletion of angiotensin-converting enzyme 2 promotes the development of atherosclerosis and arterial neointima formation. Cardiovasc Res. 2014 Feb 1;101(2):236-46
All references(73)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory